Cancer Research and Treatment

Medium - term ( Nine weeks Method for Assay of Preventive Agents Against Tumors: Taik Ku Yun, Sung Ho Kim, Yeong Ran Oh; J Korean Cancer Assoc. 1987;19(1):1-8.

Abstract PDF: For short-term carcinogenesis experirnents using animals, a method studying the incidence of pulmonary adenoma in newborn mice has been generally adopted, but this method still needs mote than 24 weeks. This expenment is one of the attempts to make such experiment period shorter. In this experimeit, both'inbred mice such as C57BL/6J, C57BR/cdJ, A/J strain and non- inbred NIH(GP) strain were used. Each mouse group was sacrificed nine weeks after a single injection of benzo(a)pyrene into subscapular region within 24 hours after birth. In C57BL/6J or C57BR/cdJ mice, no pulmonary adenoma was observed at either normal control group or bepzo(a)pyrene-injected groups by 0. 5 mg or I mg. In A/J inbred mice, however, the incidences of pulmonary adenoma were 3.9 per cent at normal control group, 86,7 per cent at 0.5 mg benzo(a)pyreae group and 88. 3 per cent at I mg benzo(a)pyrene group, respectively. In non-inbred NiH(GP) mice, the incidences were 2.5 per cent at normal group, 46. 8 per cent at 0. 5 mg group and 54. 4 per cent at 1 mg group, respectively. To verify he utility of this experiment, an NIH(GP) newborn mouse group, after inje- ction of 500 pw of benzo(a)pyrene, was administered ascorbric acid through drinking water for six weeks after they were weaned. it was observed that the pulmonary adenoma incidence was 46.8 per cent at the group injected 500 ug of benzo(a)pyrene only wbile it was decreased to 29. 5 per cent at the group administered both SQl pg of benso(a)pyrene and ascorbic acid, thus showed 37 per cent of the Prevention effect. It was proved from the above result that this method was useful to detect anticarcinogenes.

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Radiation Therapy of Skin Cancer - A study of skin tumor in 16 cases -: Hyung Chul Kwon, Sei Chul Yoon, Yong Whee Bahk; J Korean Cancer Assoc. 1987;19(1):8-14.

Abstract PDF: University Medical College The authars analysed 16 cases of skin tumor treated with external irvadiation from Sept. 1983 to Dec. 1986 at the Division of Therapeutic Radiology, Department of Radiology Catholic University Medical College. The results were as follows; I) The age ranged from 22 to 8 years. Male predominated over female(12: 4) 2) The histopathologic types of skin cancer were squamous cell carcinoma 10 cases, basal cell carcinoma and keratoacanthoma 2 cases each, Kimura's disease and mycosis fungoides 1 case each. The most common location of skin cancer was face aed extremity (4 cases each), followed by nose, lip and trunk (2 cases), eyelid and scalp(1 case). 3) The tumor dose of 2,000-7,000 cGy/2~7 weeks were delivered with a schedule of fractionation(5 fx./wk), depending on the type of histopathology. 4) Clinical respones were complete remi sion in 4 cases, partial remissian in 8 cases, improvement in 3 cases, no change in 1 case. 5) Local recurrence was noted in 2 cases, regional node metastasis in 2 caaes, and distant metastasis in 2 cases. 6) Erythema and pigmentation were seen in 10 cases, vesiculation and fibrosis in 5 cases, and ulceration in 1 case.

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Natural Killer Cell Activity of Human Peripheral Blood Lymphocytes: Taik Ku Yun, Yeon Sook Yun, Sung Kee Jo, Hae Sun Moon; J Korean Cancer Assoc. 1987;19(1):14-23.

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Liposarcoma of the Female Breast - A case report -: Seong Kwon Hong, Won Jyun Cho, Young Kwan Park, Sang Suk Lee, Eun Sook Chang; J Korean Cancer Assoc. 1987;19(1):23-28.

Abstract PDF: Liposarcoma, a malignant lesion of adipose tissue, may occur wherever fat is present but most of them are developed in lower extremity and retroperitoneum. However, liposarcoma of the mammary gland is extremely rare and only scattered cases were reported until now throughout the world, Various etiologic factors such as repeated stimulation of certain chemical agent and repeated extrinsic trauma have been considered but all of them are not definite. Differential diagnosis with variety of benign tumor and confirmation of the status of cell differentiation are important in making the plan of the treatment. Surgical management of the liposarcoma of the breast is nearly the same as other breast cancer but every surgeon sbould do more aggresive operation eventhough he meet tumors with pseudoencapsulation because inadequate resection of such case usually accompanied recurrence at surrounding soft tissues. Radiation therapy gives an excellent result especially in embryonal myxoliposarcoma. One case of liposarcoma that was developed at left breast of 73 year old korean female was treated by authors so reported the case and reviewed literatures.

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Effects of Copolang on Murine Immune Fuction and Antitumor Activity: Sung Kee Jo, Sung Ho Kim, Taik Ku Yun; J Korean Cancer Assoc. 1987;19(1):28-36.

Abstract PDF: The examinations were conducted with Copolang (protein bound polysaccharides from na- tural Coriolus versicolor) and PSK(protein bound polysaccharides from cultured Coriolas versicolar) referring to anti-tumor effect on several experimental tumor lines, influence on host immune function and its toxicity. Acute toxicity of Copolang could not be observed because the case of death was occured at higher dose administrations. There were significant inhibition of tumor growth in Sarcoma 180 by intraperitoneal administration of Copolang or PSK compared with control(p<0.01), Two cases of complete tumor regression was observed in the Copolang or PSK,treatment group. However, the results indicated that Copolang or PSK did not inhibit the growth of L1210 solid tumor and not prolonged life span of L1210 or P 388 tumor bearing mice. Natural killer ce11 activities of splenic lymphocytes and non-adherent peritoneal exudate cells were augmented by Copolang administration in EL-4 transplanted C57BL/6 mice. Cytoto.xicity of T lymphocyte against EL-4 was enhanced by Copolang in the tumor-bearing mice.

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Clinical Study of Recurrent Colorectal Cancer: Oh Hoong Kwon, Seung Ik Ahn, Jae Gahb Park, Jin Pok Kim; J Korean Cancer Assoc. 1987;19(1):36-42.

Abstract PDF: Porty patients underwent reoperations for the recurred colorectal cancer at the Department of Surgery, Seoul National University Hospital, from January 1976 to December 1985, The results of reoperation for 37 cases with first pathologic report was analysed retrospectively. The overall postoperative mortality was 5% and the morbidity was 43%, Mortality was 33% after enterostomy, but nil after bypass procedure or exploratory laparotomy or resection. The mean survival time was 19+-18 months and median survival time was 14 month. The cumulative 5 year survival rate was 10+-6%. Resection gave significantly better survival figures than the other procedures. After radical resection, mean and median survival times (37+-23 months and 30 months) were significantly prolonged. Disease extent. of recurrent tumor was correlated well with survival time. The mean for local recurrence was 48+-27 months, while the means for regional and distant recurrence being, 19+-13 and 12+-10 months respectively. The authors conclade that for these recurred colorectal cancer patients, resection may offer the best outloak as regards survival, but recurrent state of the colorectal cancer should be considered.

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