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Volume 18(2); 1986
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Original Articles
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Histopathologic Study of 27 Caces of Mucosal Malignant Melanomas
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Woo Ho Kim, Seong Hoe Park, Hyun Soon Lee
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J Korean Cancer Assoc. 1986;18(2):177-183.
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Abstract
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- We review the cases of mucosal malignant melanomas diagnosed at the Seoul National University, Department of Pathology between 1970 and 1983. Among 73 cases of malignant melanomas 27 cases arised fram mocosa. The incidence of mucosal malignant melanoma in this study was much higher when compared to that of Caucasians. Thirty-three percent of mucosal malignant melanoma had metastatic lesion at the time of first operation, which ia much lower than the incidence of metastasis in patients with cutaneous melanomas. The predilection sites of mucosal melanoma included oral cavity, conjunctiva and rectum. The conjunctival melanoma was distinguished from the rectal melanoma by the small size, short history, young age and lower incidence of metastasis.
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Thermal Distribution and Development of RF Hyperthermia for Cancer Treatment
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Sung Sil Chu, Gwi Eon Kim, John J. K. Loh, Byung Soo Kim, Min Yong Park, Sung Wha Yang, Dong Kun Jung
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J Korean Cancer Assoc. 1986;18(2):183-194.
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Abstract
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- The biological effects for the use of hyperthermia to treat malignant tumors has been well studied and encouraging clinical results have been reported. However, the engineering and technical aspects of hyperthermia for the deep-seated tumors has not been satisfactory. We have developed the RF capacitive hyperthermia device (Greenytherm-GY 8) by coopera- tion with Yonsei Cancer Center and Green Cross Medical Corporation. It was composed with 8-10 MHz RF generator, capacitive electrode, matching system, cooling system, tem- perature measuring thermocouples and control PC computer. We have measured the tempe- rature and thermal distribution in agar phantom, animals and human tumors. This RF hyperthermia device could be applied for clinical trials as result of following studies. 1) The generating power could be varied to 700-1500 W 2) The Radio-frequency for capacitive heating could be produced to 8-10 MHz 3) It was possible to contral the depth heating from skin by regulation the cooling tem- perature of bolus and choosing properly size electrodes. 4) Deep seated tumors (5-10 cm depth) might be heated to therapeutic temperature 40- 43' C. 5) Side effects and hot feeling on skin could be significantly reduced by cooling bolus and electric matching.
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A Study on Histologic Type of Gastric Carcinoma - Analysis of Clinico - Pathologic Charcaterization and Its Implication as a Prognostic Factor -
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Won Jin Choi, Jin Pok Kim
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J Korean Cancer Assoc. 1986;18(2):194-214.
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Abstract
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- This study was designed to investigate the distribution of histologic types of gastric carcinoma and to assess the implication of its histologic type as a prognostic factor. A total of 826 cases of the resected stomach examined at Seoul National University Hospital during the period of 7 years from January 1974 to December 1980 were classified according to Lauren's method based on the histo-topographical investigation:. The results were summarized as follows: 1) The mean age of gastric carcinoma patient was 51.7 years; 52.8 years in male and 49 4 years in female. Male to female ratio was 2.0: 1. 2) When classified by Laurens method, 52.3%(432/836) of total cases were intestinal type carcinoma, 42.7%(347/826) diffuse type and 5. 7%(47/826) mixed type. 3) Most(74.5) of the intestinal type carcinoma and more than half(59.4%) of the diff- use type carcinoma were the cases of males. The incidence of the intestinal type carcinoma was 1. 5 times(312:206) higher than the diffuse type carcinoma in males, while the diffuse type was l. 2 times(141;120) higher than the intestinal type in females. The peak incidence was in the age group of 50-59 years in both types, however, the diffuse type occurred more frequently in younger age group than the intestinal one. The mean age of the diffuse type carcinoma was 48.9 vears, while that of the intestinal type was 54.1 years. 4) The pathological characteristics of two types are different in many aspects with a statistical significance(p<0. 05), The tumor size of the diffuse type was larger than that of the intestinal type, and the former was located more diffusely and comprised a less proportion of Borrmann type I and g and a larger proportion of Borrmann type lV than the latter type. The diffuse type showed more frequent metastasis to regional lymph nodes and invaded the gastric wall more deeply than the intestinal type. 5) Intestinal metaplasia in the neighboring mucosa was found in almost all(95.8%) of he intestinal type, but in 62. 5% of the diffuse type. 6) The 5-year survival rate of the intestinal type(43.7%) was higher than that of the diffuse type(30.4%) with a statistical significance(p<0. 01), in a series of 337 follow-up cases, 7%) Lauren's histologic type itself affected the postoperative prognosis according to Cax proportional hazard model, with which the intestinal type showed better prognosis than the diffuse type.
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Significance of CEA Measurement in Colorectal Carcinoma
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Jin Pok Kim, Sun Whe Kim
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J Korean Cancer Assoc. 1986;18(2):215-225.
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Abstract
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- Preoperative plasma CEA levels were measured in 502 Patients with colorectal cancer and were examined for clinical significance in disease extent and prognosis. The progress of 261 Patients operated upon for cure of colorectal carcinoma was followed postoperatively with a standardized protocol and significance of plasma CEA level for detection of recurrence, timing of detection and site of recurrence was analysed. The preoperative CEA levels showed normal value(less than 2. 5 ng/ml) in 27. 7% of cases, however, it showed relatively good correlation with disease extent, resectability, histologic differentiation, survival and disease free survival, significant difference of which were noted between lower than 5 ng/ml group and 5 ng/ml or higher group. TVhen the upper limit for CEA of 5 ng/ml was allowed, sensitivity, specificity and pre- dictive value for recurrence were 78.3%, 89.3% and 80% respectively. Median interval between CEA elevation and clinical recurrence was 2.1 months. Site of recurrence-locore- gional or distant-was correlated with CEA level at recurrence.
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