- Gastrointestinal cancer
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Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11
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Chenyang Qi, Liping Zou, Suxia Wang, Xing Mao, Yuan Hu, Jiaoyu Shi, Zhigang Zhang, Huijuan Wu
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Cancer Res Treat. 2022;54(1):182-198. Published online March 26, 2021
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DOI: https://doi.org/10.4143/crt.2020.578
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 Abstract
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- Purpose
The role of vacuolar protein sorting 34 (Vps34), an indispensable protein required for cell vesicular trafficking, in the biological behavior of hepatocellular carcinoma (HCC) has yet to be studied.
Materials and Methods
In the present study, the expression of Vps34 in HCC and the effect of Vps34 on HCC cell invasion was detected both in vivo and in vitro. Furthermore, by modulating the RILP and Rab11, which regulate juxtanuclear lysosome aggregation and recycling endosome respectively, the underlying mechanism was investigated.
Results
Vps34 was significantly decreased in HCC and negatively correlated with the HCC invasiveness both in vivo and in vitro. Moreover, Vps34 could promote lysosomal juxtanuclear accumulation, reduce the invasive ability of HCC cells via the Rab7-RILP pathway. In addition, the deficiency of Vps34 in HCC cells affected the endosome-lysosome system, resulting in enhanced Rab11 mediated endocytic recycling of cell surface receptor and increased invasion of HCC cells.
Conclusion
Our study reveals that Vps34 acts as an invasion suppressor in HCC cells, and more importantly, the endosome-lysosome trafficking regulated by Vps34 has the potential to become a target pathway in HCC treatment.
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Citations
Citations to this article as recorded by  - Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
Mona Tahoun, Ahmed S. Sadaka
Human Immunology.2024; 85(3): 110801. CrossRef - Prognostic Lysosome-Related Biomarkers for Predicting Drug Candidates in Hepatocellular Carcinoma: An Insilco Analysis
Junxiu Xu, Kai Zhang, Genhao Zhang
Journal of Hepatocellular Carcinoma.2023; Volume 10: 459. CrossRef - Targeting VPS34 in autophagy: An update on pharmacological small-molecule compounds
Yuan Liu, Qilin Yang, Siwei Chen, Zixiang Li, Leilei Fu
European Journal of Medicinal Chemistry.2023; 256: 115467. CrossRef - RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway
Zhun Wei, Kezhou Xia, Di Zheng, Changtian Gong, Weichun Guo
Molecular Medicine.2023;[Epub] CrossRef - The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer
Chien-An Chu, Yi-Wen Wang, Yi-Lin Chen, Hui-Wen Chen, Jing-Jing Chuang, Hong-Yi Chang, Chung-Liang Ho, Chen Chang, Nan-Haw Chow, Chung-Ta Lee
International Journal of Molecular Sciences.2021; 22(20): 10964. CrossRef
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