- Gastrointestinal cancer
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Systemic Inflammatory Biomarkers, Especially Fibrinogen to Albumin Ratio, Predict Prognosis in Patients with Pancreatic Cancer
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Lin Fang, Fei-Hu Yan, Chao Liu, Jing Chen, Dan Wang, Chun-Hui Zhang, Chang-Jie Lou, Jie Lian, Yang Yao, Bo-Jun Wang, Rui-Yang Li, Shu-Ling Han, Yi-Bing Bai, Jia-Ni Yang, Zhi-Wei Li, Yan-Qiao Zhang
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Cancer Res Treat. 2021;53(1):131-139. Published online August 24, 2020
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DOI: https://doi.org/10.4143/crt.2020.330
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Abstract
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- Purpose
Systemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine and compare the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) in resectable PC and locally advanced or metastatic PC.
Materials and Methods Three hundred fifty-three patients with resectable PC and 807 patients with locally advan-ced or metastatic PC were recruited in this study. These patients were classified into a training set (n=758) and a validation set (n=402). Kaplan-Meier survival plots and Cox proportional hazards regression models were used to analyze prognosis.
Results Overall survival (OS) was significantly better for patients with resectable PC with low preoperative PLR (p=0.048) and MLR (p=0.027). Low FAR, MLR, NLR (p < 0.001), and PLR (p=0.003) were significantly associated with decreased risk of death for locally advanced or metastatic PC patients. FAR (hazard ratio [HR], 1.522; 95% confidential interval [CI], 1.261 to 1.837; p < 0.001) and MLR (HR, 1.248; 95% CI, 1.017 to 1.532; p=0.034) were independent prognostic factors for locally advanced or metastatic PC.
Conclusion The prognostic roles of FAR, MLR, NLR, and PLR in resectable PC and locally advanced or metastatic PC were different. FAR showed the most prognostic power in locally advanced or metastatic PC. Low FAR was positively correlated with OS in locally advanced or metastatic PC, which could be used to predict the prognosis.
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Citations
Citations to this article as recorded by
- Prognostic value of preoperative white blood cell to hemoglobin ratio and fibrinogen to albumin ratio in patients with colorectal cancer
Kang Li, Jing Yan, Haifeng Zhang, Chunlei Lu, Weijia Wang, Mingxiao Guo, Xiaoming Zhang, Zhaoyong Zhang Medicine.2024; 103(3): e37031. CrossRef - Prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with chronic heart failure across the different ejection fraction spectrum
Sirui Yang, Jiangyuan Pi, Wenfang Ma, Wenyi Gu, Hongxing Zhang, Anyu Xu, Yanqing Liu, Tao Shi, Fazhi Yang, Lixing Chen Libyan Journal of Medicine.2024;[Epub] CrossRef - Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
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Huanjie Zhou, Haiping Zheng, Ying Wang, Ming Lao, Hong Shu, Meifang Huang, Chao Ou Cancer Control.2024;[Epub] CrossRef - Predictive value of serum albumin levels on cancer survival: a prospective cohort study
Quan Tang, Xu Li, Chun-Rong Sun Frontiers in Oncology.2024;[Epub] CrossRef - Combining systemic inflammatory response index and albumin fibrinogen ratio to predict early serious complications and prognosis after resectable gastric cancer
Jing-Yao Ren, Da Wang, Li-Hui Zhu, Shuo Liu, Miao Yu, Hui Cai World Journal of Gastrointestinal Oncology.2024; 16(3): 732. CrossRef - A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke
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Yanan Sun, Jiahe Hu, Rongfang Wang, Xinlian Du, Xiaoling Zhang, Jiaoting E, Shaoyue Zheng, Yuxin Zhou, Ruishu Mou, Xuedong Li, Hanbo Zhang, Ying Xu, Yuan Liao, Wenjie Jiang, Lijia Liu, Ruitao Wang, Jiuxin Zhu, Rui Xie Cancer Medicine.2024;[Epub] CrossRef - The prognostic role of lymphocyte-to-monocyte ratio in patients with resectable pancreatic cancer: a systematic review and meta-analysis
Haipeng Li, Shang Peng, Ran An, Nana Du, Huan Wu, Xiangcheng Zhen, Yuanzhi Gao, Zhenghong Li, Jingting Min PeerJ.2024; 12: e17585. CrossRef - Monocyte to high-density lipoprotein ratio based prognostic nomogram for patients following allogeneic vascular replacement pancreaticoduodenectomy
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Shaofei Chang, Yiping Zou, Jing Huang, Zhifei Li, Yuexiang Liang, Song Gao World Journal of Surgical Oncology.2024;[Epub] CrossRef - Derivation and validation of a preoperative prognostic model for resectable pancreatic ductal adenocarcinoma
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Yuanlong Gu, Qianjin Hua, Zhipeng Li, Xingli Zhang, Changjie Lou, Yangfen Zhang, Wei Wang, Peiyuan Cai, Juan Zhao BMC Cancer.2023;[Epub] CrossRef - Systemic immune-inflammation index predicts prognosis and responsiveness to immunotherapy in cancer patients: a systematic review and meta‑analysis
Junyan Kou, Jing Huang, Jun Li, Zhen Wu, Liwei Ni Clinical and Experimental Medicine.2023; 23(7): 3895. CrossRef - Prognostic analysis of the plasma fibrinogen combined with neutrophil‐to‐lymphocyte ratio in patients with non–small cell lung cancer after radical resection
Gao‐Xiang Wang, Zhi‐Ning Huang, Ying‐Quan Ye, Shan‐Ming Tao, Mei‐Qing Xu, Mei Zhang, Ming‐Ran Xie Thoracic Cancer.2023; 14(15): 1383. CrossRef - Clinical features of patients with MOG-IgG associated disorders and analysis of the relationship between fibrinogen-to-albumin ratio and the severity at disease onset
Yue Li, Sai Wang, Panpan Liu, Jinxiu Ma, Xinjing Liu, Jing Yuan Frontiers in Neurology.2023;[Epub] CrossRef - Low albumin‐to‐fibrinogen ratio predicts adverse clinical outcomes after primary total joint arthroplasty: A retrospective observational investigation
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