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Characteristics, Prognostic Factors, and Survival of Patients with NK/T-Cell Lymphoma of Non-upper Aerodigestive Tract: A 17-Year Single-Center Experience
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Ze-Long Liu, Xi-Wen Bi, Xue-Wen Zhang, De-Xin Lei, Pan-Pan Liu, Hang Yang, Yan Gao, Yuan-Xue Jiang, Wen-Qi Jiang, Yi Xia
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Cancer Res Treat. 2019;51(4):1557-1567. Published online April 1, 2019
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DOI: https://doi.org/10.4143/crt.2018.681
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 Abstract
 PDF Supplementary Material PubReader ePub
- Purpose
The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL.
Materials and Methods
From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12.2%) and 665 UAT-NKTCL
patients (87.8%).
Results
NUAT-NKTCL patients had relatively poorer performance status, more unfavorable prognostic factors, and more advanced stage, compared with UAT-NKTCL patients. The 5-year overall survival (OS) was 34.7% for NUAT-NKTCL, which was significantly worse than UAT-NKTCL (64.2%, p<0.001). The median OS duration was 30.9 months for NUAT-NKTCL. Multivariate analysis showed that presence with B symptoms and elevated serum lactate dehydrogenase independently predicted worse OS. International prognostic index score and prognostic index of natural killer lymphoma score still had prognostic values in NUAT-NKTCL, while the Ann Arbor system could not accurately predict the OS.
Conclusion
NUAT-NKTCL is a distinctive subtype of NKTCL in many aspects. Patients with NUAT-NKTCL have relatively poorer performance status, more unfavorable prognostic factors, more advanced stage, and poorer prognosis.
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Citations
Citations to this article as recorded by  - Clinical features, prognostic stratification, and treatment of advanced-stage non-nasal type extranodal natural killer/T-cell lymphoma: a multi-institutional real-world study
Yu-Ce Wei, Wei-Xin Liu, Fei Qi, Chang-Gong Zhang, Bao-Min Zheng, Yan Xie, Bo Chen, Di Zhang, Wei-Ping Liu, Hui Fang, Yue Chai, Shu-Nan Qi, Ye-Xiong Li, Wei-Hu Wang, Yu-Qin Song, Jun Zhu, Mei Dong
Annals of Hematology.2024; 103(1): 163. CrossRef - Genomic features reveal potential benefit of adding anti-PD-1 immunotherapy to treat non-upper aerodigestive tract natural killer/T-cell lymphoma
Zegeng Chen, He Huang, Huageng Huang, Le Yu, Huawei Weng, Jian Xiao, Liqun Zou, Huilai Zhang, Chaoyong Liang, Hui Zhou, Hongqiang Guo, Zhao Wang, Zhiming Li, Tao Wu, Hongyu Zhang, Huijing Wu, Zhigang Peng, Linzhu Zhai, Xinggui Chen, Yang Liang, Huangming
Leukemia.2024; 38(4): 829. CrossRef - Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020
Yang Chunli, Jiang Ming, Ma Ziyan, Ji Jie, Lv Shuli, Huang Jie, Wu Yu, Xu Caigang, Zou Liqun
Cancer Medicine.2023; 12(3): 2614. CrossRef - Diagnostic and prognostic value of pretreatment PET/CT in extranodal natural killer/T-cell lymphoma: a retrospective multicenter study
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Journal of Cancer Research and Clinical Oncology.2023; 149(11): 8863. CrossRef - Comparative analysis of upper aerodigestive tract and non-upper aerodigestive tract in NK/T-cell lymphoma
Xiaohong Liu, Dedong Cao, Hui Liu, XiaoKang Ke, Xin Liu, Ximing Xu
Clinical and Translational Oncology.2023; 26(1): 214. CrossRef - Intensive therapy can improve long‐term survival in newly diagnosed, advanced‐stage extranodal NK/T‐cell lymphoma: A multi‐institutional, real‐world study
Yu‐Ce Wei, Fei Qi, Bao‐Min Zheng, Chang‐Gong Zhang, Yan Xie, Bo Chen, Wei‐Xin Liu, Wei‐Ping Liu, Hui Fang, Shu‐Nan Qi, Di Zhang, Yue Chai, Ye‐Xiong Li, Wei‐Hu Wang, Yu‐Qin Song, Jun Zhu, Mei Dong
International Journal of Cancer.2023; 153(9): 1643. CrossRef - A retrospective study on the clinicopathological and molecular features of 22 cases of natural killer/T-cell lymphoma in children and adolescents
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Scientific Reports.2022;[Epub] CrossRef - Comparison analysis of first-line asparaginase- versus non-asparaginase-based regimens for early-stage extranodal NK/T-cell lymphoma
Fei Qi, Yan Xie, Dedao Wang, Yue Chai, Bo Chen, Yan Sun, Weiping Liu, Shunan Qi, Yuce Wei, Hui Fang, Dan Zhao, Lin Gui, Yong Yang, Xiaoli Feng, Ning Ding, Lan Mi, Shaokun Shu, Yexiong Li, Yuqin Song, Mei Dong, Jun Zhu
Annals of Hematology.2022; 101(9): 2021. CrossRef
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