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Immunohistochemical Study for CD44v6 in Hepatocellular Carcinoma and Cholangiocarcinoma
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Ki Jung Yun, Kwon Ha Yoon, Weon Cheol Han
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Cancer Res Treat. 2002;34(3):170-174. Published online June 30, 2002
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DOI: https://doi.org/10.4143/crt.2002.34.3.170
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 Abstract
 PDF
- PURPOSE
CD44 is a multifunctional adhesion molecule in cell-to-cell and cell-to-matrix interactions. This transmembrane glycoprotein exists in either standard or variant form, with the variation originating in alternative splicing. This study was designed to evaluate the role of CD44v6, one of the CD44 isoforms, in hepatocellular carcinoma and cholangiocarcinoma.
MATERIALS AND METGODS: Immunohistochemical expression of CD44v6 was studied in 7 normal livers, 14 hepatocellular carcinomas and 16 cholangiocarcinomas, that were formalin fixed and paraffin embedded.
RESULTS
CD44v6 was frequently expressed in the normal hepatocytes and hepatocellular carcinomas. Expression was not noted in the normal bile duct within the portal tract.
CD44v6 was positively expressed in some of the proliferating bile ducts (43%) and cholangiocarcinomas (69%).
CONCLUSION
CD44v6 expression may be more important in the stepwise carcinogenesis of the bile duct than in the normal hepatocyte, but further study is needed.
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Citations
Citations to this article as recorded by  - Impact of Alternative Splicing Variants on Liver Cancer Biology
Jose J. G. Marin, Maria Reviejo, Meraris Soto, Elisa Lozano, Maitane Asensio, Sara Ortiz-Rivero, Carmen Berasain, Matias A. Avila, Elisa Herraez
Cancers.2021; 14(1): 18. CrossRef - Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)
Juthamas Yosudjai, Sopit Wongkham, Siwanon Jirawatnotai, Worasak Kaewkong
Biomedical Reports.2019;[Epub] CrossRef - An aberrantly spliced isoform of anterior gradient-2, AGR2vH promotes migration and invasion of cholangiocarcinoma cell
Juthamas Yosudjai, Chaturong Inpad, Sasitorn Chomwong, Paweena Dana, Kanlayanee Sawanyawisuth, Suchada Phimsen, Sopit Wongkham, Siwanon Jirawatnotai, Worasak Kaewkong
Biomedicine & Pharmacotherapy.2018; 107: 109. CrossRef - Prognostic Significance of CD44s Expression in Biliary Tract Cancers
Sang Min Lee, Kyoung Eun Lee, Hye Jung Chang, Moon Young Choi, Min-Sun Cho, Seog Ki Min, Hyeon Kook Lee, Yeung Chul Mun, Eun Mi Nam, Chu Myong Seong, Soon Nam Lee
Annals of Surgical Oncology.2008; 15(4): 1155. CrossRef
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Immunohistochemical Study of beta-catenin Expression between Hepatocellular Carcinoma and Cholangiocarcinoma
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Ki Jung Yun, Weon Cheol Han, Suck Chei Choi, Tae Hyeon Kim
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Cancer Res Treat. 2002;34(2):117-121. Published online April 30, 2002
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DOI: https://doi.org/10.4143/crt.2002.34.2.117
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Abstract
PDF
- PURPOSE
beta-catenin is an intracellular protein that is an integral component of the cadherin-mediated cell-cell interaction and a downstream transcriptional activator in the wnt signal transduction pathway. Inappropriate activation of beta-catenin has recently been implicated in the development of hepatocellular carcinoma and cholangiocarcinoma. Nuclear beta-catenin expression is strongly associated with gene mutation. This study was designed to evaluate the pattern of beta-catenin expression between hepatocellular carcinoma and cholangiocarcinoma.
MATERIALS AND METHODS
Immunohistochemical expression of beta-catenin was studied in 7 normal livers, 33 hepatocellular carcinomas and 20 cholangiocarcinomas, that were formalin fixed and paraffin embedded.
RESULTS
beta-catenin was expressed mainly in the cytoplasmic membrane of the normal hepatocytes and bile ducts. Nuclear expressions, not noted in the normal liver, were noted in 30% of the hepatocellular carcinomas and 10% of the cholangiocarcinomas. And, nuclear expression was more common in the high grade (50%) hepatocellular carcinomas than the low grade (18%) hepatocellular carcinomas (p<=0.05).
CONCLUSION
The above results indicate that nuclear expression of beta-catenin is observed in the carcinoma but not the normal liver, and is associated with high grade liver carcinoma.
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Citations
Citations to this article as recorded by - Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42
Xifang Wang, Xiaomin Zhang, Jingying Sun, Yang Sun, Yuan Zhang, Li He, Ping Wang, Feng Li, Chao Sun
Toxicology and Applied Pharmacology.2023; 467: 116492. CrossRef - Impact of Aberrant β-Catenin Pathway on Cholangiocarcinoma Heterogeneity
Elisa Lozano, Paula Sanchon-Sanchez, Ana Morente-Carrasco, Luis Miguel Chinchilla-Tábora, José L. Mauriz, Paula Fernández-Palanca, Jose J. G. Marin, Rocio I. R. Macias
Cells.2023; 12(8): 1141. CrossRef - Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma
Guo-Feng Zhang, Ling Qiu, Shu-Li Yang, Jia-Cheng Wu, Tong-Jun Liu
Bioscience Reports.2020;[Epub] CrossRef - β-Catenin expression is associated with cell invasiveness in pancreatic cancer
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
The Korean Journal of Internal Medicine.2019; 34(3): 618. CrossRef - A Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers
Jennifer Raisch, Anthony Côté-Biron, Nathalie Rivard
Cancers.2019; 11(8): 1162. CrossRef - Beta-Catenin Downregulation Contributes to Epidermal Growth Factor-induced Migration and Invasion of MDAMB231 Cells
Arang Kwon, Hyun-Jung Park, Jeong-Hwa Baek
International Journal of Oral Biology.2018; 43(3): 161. CrossRef - Genetic alterations of Wnt signaling pathway–associated genes in hepatocellular carcinoma
Young‐Dae Kim, Chang‐Hwan Park, Hyun‐Soo Kim, Sung‐Kyu Choi, Jong‐Sun Rew, Dong‐Yi Kim, Yang‐Suk Koh, Kyung‐Woon Jeung, Kyung‐Hwa Lee, Ji‐Shin Lee, Sang‐Woo Juhng, Jae‐Hyuk Lee
Journal of Gastroenterology and Hepatology.2008; 23(1): 110. CrossRef
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