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Prognostic Significance of VEGF in Human Stomach Cancer
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Gue Sung Han, Sung Jae Cha, Young Kum Park, Kyong Choun Chi, Sung Jun Park, Hyun Mook Lim, Sung II Park, Un Sub Park
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J Korean Cancer Assoc. 1999;31(6):1087-1093.
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 Abstract
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- PURPOSE
Angiogenesis plays an important role in the growth, progression and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) was thought to be one such angiogenic factor and was also thought to be a selective mitogen for endothelial cells. The purpose of this retrospective study was to evaluate for prognostic significance of VEGF in stomach cancer.
MATERIALS AND METHODS
The sections of formalin-fixed, paraffin embedded from 55 stomach cancer were stained immunohistochemically for VEGF. The rate of VEGF expression and correlation between expression of VEGF and other prognostic factor of stomach cancer were studied.
RESULTS
There were 20 cases (36.4%) of VEGF-positive and 35 cases (63.6%) of VEGF- negative. There were no significant difference between VEGF expression and the histologic type, differentiation, depth of invasion of histologic stage, lymph node involvement. The frequency of hepatic recurrence was higher in patients with VEGF-positive tumor than that af patient with negative tumor (p=0.007). The prognosis of the patients with VEGF positive tumor was worse than that of patients with VEGF negative tumor (p=0.0214).
CONCLUSION
There was a closely significant between positive expression of VEGF and a high incidence of hepatic metastasis, low survival rate. The expression of VEGF could be considered to be one of useful prognostic factor in human gastric carcinoma
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VEGF Expression and MVD in Ductal Carcinoma of Breast
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Seong Jon Jeong, Sung Jun Park, Sung Jae Cha, Young Kum Park, Kyong Choun Chi, Hyun Mook Lim, Sung II Park, Tae Jin Lee, Un Sub Park
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J Korean Cancer Assoc. 1999;31(6):1168-1178.
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Abstract
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- PURPOSE
This study was aimed to determine the role of the VEGF and MVD expression in infiltrating ductal carcinoma of breast and to observe the correlation between the expression of these VEGF/MVD, and other prognostic factors.
MATERIALS AND METHODS
Immunohistochemical staining of VEGF and MVD with monoclonal antibody in pathologic specimens of 35 patients of infiltrating ductal carcinoma of breast was carried out. Reiationship between the expression of the VEGF/MVD and prognostic factors were assessed.
RESULTS
The VEGF/MVD expression was closely related to tumor size, lymph node metastasis, and clinical stage, but not related to histologic grade, nuclear grade, estrogen receptor, and progestrone receptor. And the VEGF expression was closely related to MVD.
CONCLUSION
The VEGF expression and microvessel density in infiltrating ductal carcinoma of breast may play an important prognostic factors, closely related to the tumor size, lymph node metastasis, and stage.
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KCA
