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No Association between Catalase Gene Polymorphism and Gastric Carcinoma and Hepatocellular Carcinoma in Koreans
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Ji Hyun Lee, Ran Young Park, Chang Soo Lee, Euh Jun Jeoung, Su Youn Nam, Jae Gun Lee, Kye Young Han, Hee Jae Lee, Joo Ho Chung, Yun Gul Ahn, Sung Vin Yim, Jae Young Cho, Yeon Hee Park
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Cancer Res Treat. 2002;34(6):432-435. Published online December 31, 2002
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DOI: https://doi.org/10.4143/crt.2002.34.6.432
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 Abstract
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Oxidative stress has been implicated in the pathogenesis of various diseases. Catalase is one of the main defense mechanisms against oxidative stress. To examine the possible relationship between oxidative stress, and gastric and hepatocellular carcinomas, HinfI restriction length polymorphism (RFLP) in the human catalase gene was assessed.
MATERIALS AND METHODS
The genotype and allele frequencies in the promoter region of the catalase gene were studied by PCR-RFLP in 108 Korean controls, 80 Korean gastric carcinoma (GC) and 106 Korean hepatocellular carcinoma (HCC) patients.
RESULTS
No statistically significant differences were found in the genotypic distribution and allelic frequencies between the controls and both types of carcinoma patient.
CONCLUSION
To address the possible contribution of oxidative stresses to the pathogenesis of gastric and hepatocellular carcinomas, the associations between the catalase gene polymorphism and GC and HCC susceptibilities were studied. As a result, the catalase gene polymorphism was found not to be determinant of GC and HCC susceptibilities. Further studies are required on various other oxidative stress related genes to elucidate the mechanisms of GC and HCC.
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Citations
Citations to this article as recorded by  - Organelle stress and alterations in interorganelle crosstalk during liver fibrosis
Saloni Sinha, Nora Hassan, Robert E. Schwartz
Hepatology.2024; 79(2): 482. CrossRef - Two common functional catalase gene polymorphisms (rs1001179 and rs794316) and cancer susceptibility: evidence from 14,942 cancer cases and 43,285 controls
Kang Liu, Xinghan Liu, Meng Wang, Xijing Wang, Huafeng Kang, Shuai Lin, Pengtao Yang, Cong Dai, Peng Xu, Shanli Li, Zhijun Dai
Oncotarget.2016; 7(39): 62954. CrossRef - Association Between Catalase Gene Polymorphisms and Risk of Chronic Hepatitis B, Hepatitis B Virus-Related Liver Cirrhosis and Hepatocellular Carcinoma in Guangxi Population
Yanqiong Liu, Li Xie, Jiangyang Zhao, Xiuli Huang, Liuying Song, Jingrong Luo, Liping Ma, Shan Li, Xue Qin
Medicine.2015; 94(13): e702. CrossRef
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