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The Clinical Usefulness of Membranous E-cadherin in Transitional Cell Carcinoma of the Bladder
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Bong Ryoul Oh, Gil Joo Nah, Seong Jin Kim, Jae Hong Sim, Dong Deuk Kwon, Kwang Sung Park, Soo Bang Ryu, Yang Il Park
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J Korean Cancer Assoc. 1998;30(6):1219-1226.
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 Abstract
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- PURPOSE
E-cadherin, a cell adhesive molecule that plays a diverse role in cell-cell and cell-matrix interaction, is essential for maintaining epithelial intercellular adhesion and acts particularly as a suppressor of invasive ability of cancer. To detennine the potential pro- gnostic values of membranous E-cadherin, we evaluated the correlation between the clin- ical outcome and its expression in patients with transitional cell carcinoma of the bladder.
MATERIALS AND METHODS
Membranous E-cadherin immunoreactivity was evaluated in 75 cases of transitional bladder cancer and 15 controls (5 cases of cystitis and 10 normal controls). The expression of membranous E-cadherin were compared with histological grade, T category of TNM stage, and survival.
RESULTS
Abnonnal immunohistochemical expression of membranous E-cadherin was observed in 53 (70.7%) patients with bladder cancer and undetected in controis. Abnormal immunohistochemical expression of membranous E-cadherin was significantly correlated with grade (p<0.01) and T category of TNM stage (p<0.01) of transitional cell carcinoma of the bladder. Progression to invasive cancer occurred in 6 patients with 45 superficial bladder cancer and 5 of them showed abnormal expression of E-cadherin, which had statistical significance (p<0.05) but not with recurrence.
There was statistically significant correlation between the abnormal expression of E-cadherin and poor prognosis (p < 0.01).
CONCLUSIONS
We conclude that abnormal expression of membranous E-cadherin is a useful prognostic marker in patients with transitional bladder cancer.
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Urinary Nuclear Matrix Protein ( NMP 22 ) in the Detection of Transitional Cell Carcinoma of the Bladder
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Soo Bang Ryu, Bong Ryoul Oh, Soon Pal Suh, Dong Deuk Kwon, Je Woong Ryu, Yang Il Park
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J Korean Cancer Assoc. 1998;30(2):378-383.
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Abstract
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- PURPOSE
The detection of bladder cancers by noninvasive techniques remains an unsolved problem. We evaluate the availability of an immunoassay for urinary nuclear matrix protein, NMP 22, as an indicator for transitional cell carcinoma of the bladder.
MATERIALS AND METHODS
Three groups of subjects participated in this trial of NMP 22: 22 patients with transitional cell carcinoma (group 1), 12 patients with urinary tract infection (group 2) and 31 healthy volunteers (group 3). NMP 22 was determined by ELISA using a commercial test kit (NMP 22 Test Kit, Matritech Inc., USA), We compared urinary NMP 22 levels to the grade, stage, cytology and DNA flowcytometry of transitional cell carcinoma of bladder.
RESULTS
NMP 22 values in these 3 groups were significantly different (group 1, median 24.81 U/mL; group 2, median 8.41 U/mL; and group 3, median 5.12 U/mL; Mann-Whitney U test for differences between 3 medians, p < 0.05). The patients with transitional cell carcinoma had significantly greater urinary NMP 22 levels than those with no evidence of tumor (Mann-Whitney U test for differences between 2 medians, p<0.01). There was no zelationship between the urinary NMP 22 levels and tumor grade, stage, cytology or DNA flowcytometry.
CONCLUSIONS
It is possible that urinary NMP 22 could improve the detection of bladder transitional cell carcinoma.
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Pronostic Value of The Expression of Mutant p53 and EGFR mRNA in Transitional Cell Carcinoma of the Bladder
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Bong Ryoul Oh, Jae Hong Sim, Chang Soo Park, Soo Bang Ryu, Yang Il Park
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J Korean Cancer Assoc. 1997;29(4):663-672.
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Abstract
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- PURPOSE
We evaluated the correlation between the clinical outcome and the expression of p53 protein and EGFR mRNA in bladder cancer.
MATERIALS AND METHODS
Sixty seven patients with transitional cell carcinoma of the bladder (40 patients with superficial cancer and 27 patients with invasive cancer) and 10 persons with normal urothelium were included in our study. We examined the overexpression of p53 protein by immunohistochemical analysis and EGFR by in situ mRNA hybridization. Both expression were compared with the known factors of prognosis.
RESULTS
Mutant p53 protein was overexpressed in 43.3% of transitional cell carcinoma cases and undetectable in normal urothelium. The positive staining of EGFR mRNA was observed in 30% of normal urothelium and 100% of transitional cell carcinoma of bladder. p53 overexpression was related to the degree of differentiation, but not with the stage and the recurrence of superficial cancers. Progression to invasive cancer occurred in 4 patients with superficial cancer and all of them showed p53 protein overexpression, which had statistical significance (P<0.05). p53 positivity in invasive cancer was not related to the poor survival and strong expression of EGFR mRNA. The positive staining of EGFR mRNA was also not related to stage, grade, recurrence and survival. When we combined positivity of p53 and EGFR mRNA, we observed that the subset of patients with strong expression of EGFR mRNA and positive expression of p53 also had no different survival.
CONCLUSIONS
These results suggest that mutant p53 protein does not seem to be a prognostic marker for the recurrence of superficial cancer and survival but may be a marker for progression of superficial cancer to invasive cancer.
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A Case of Bladder Rhabdomyosaroma in Child
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Hee Jong Jeung, Sam Ryong Lee, Kwang Sung Park, Soo Bang Ryu, Hoon Kook, Tai Ju Hwang
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J Korean Cancer Assoc. 1996;28(3):604-611.
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Abstract
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- Embryonal rhabdomyosarcoma arises from the embryonal mesenchyme that differentiates into striated skeletal muscle, and about 15 to 20% of rhabdomyosarcomas are genitourinary in origin. Rhabdomyosarcoma of urogenital origin occurs at 2 age peaks: one in children between 2 and 6 year old and the other during adolescence between ages 15 and 19 year old. We report a case of embryonal rhabdomyosarcoma of the bladder in a 3-year-old male. He presented dysuria with straining and dribbling, and diagnosis was made by cystoscopy and biopsy. Since partial cystectomy was performed, and he has being received continuous Pulse VAC chemotherapy with radiotherapy.
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KCA
