Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Author index

Page Path
HOME > Browse articles > Author index
Search
Shin Ahn 1 Article
The Usefulness of Procalcitonin and C-Reactive Protein as Early Diagnostic Markers of Bacteremia in Cancer Patients with Febrile Neutropenia
Dae Yong Kim, Yoon-Seon Lee, Shin Ahn, Yeon Hee Chun, Kyung Soo Lim
Cancer Res Treat. 2011;43(3):176-180.   Published online September 30, 2011
DOI: https://doi.org/10.4143/crt.2011.43.3.176
AbstractAbstract PDFPubReaderePub
PURPOSE
Procalcitonin (PCT) and C-reactive protein (CRP) are well known inflammatory markers. This study was designed to determine whether PCT and CRP are useful as early diagnostic markers for bacteremia in cancer patients with febrile neutropenia (FN) in the emergency department (ED).
MATERIALS AND METHODS
In this retrospective study, 286 episodes of FN in the ED were consecutively included between June 2009 and August 2010. From medical records, clinical characteristics including PCT and CRP were extracted and analyzed.
RESULTS
Bacteremia was identified in 38 (13.3%) of the 286 episodes. The median values of PCT (2.8 ng/mL vs. 0.0 ng/mL, p=0.000) and CRP (15.9 mg/dL vs. 5.6 mg/dL, p=0.002) were significantly higher in the group with bacteremia compared to the group without bacteremia. In univariate analysis, elevated PCT (>0.5 ng/mL) and CRP (>10 mg/dL) as well as older age, hypotension, tachycardia, tachypnea, and high body temperature were significantly associated with bacteremia. On multivariate analysis, elevated PCT (>0.5 ng/mL) (odds ratio [OR], 3.6; 95% confidence interval [CI], 1.4 to 9.2; p<0.01) and tachypnea (OR, 3.4; 95% CI, 1.4 to 8.5; p<0.01) were independent early diagnostic markers for bacteremia in FN patients. The area under the curve of PCT was 74.8% (95% CI, 65.1 to 84.6%) and that of CRP was 65.5% (95% CI, 54.8 to 76.1%). With a PCT cut-off value of 0.5 ng/mL, sensitivity and specificity were 60.5% and 82.3%, respectively, while the sensitivity and specificity were 57.6% and 67.3%, respectively, with a CRP cutoff of 10 mg/dL.
CONCLUSION
These findings suggest that PCT is a useful early diagnostic marker for the detection of bacteremia in FN at the ED and has better diagnostic value than CRP.

Citations

Citations to this article as recorded by  
  • The utility of procalcitonin for diagnosing bacteremia and bacterial pneumonia in hospitalized oncology patients
    Mary K. Munsell, Temidayo Fadelu, Sherri O. Stuver, Katherine P. Baker, Brett Glotzbecker, Justin L. Simmons, Kerry L. Reynolds, Ami K. Patel
    Journal of Cancer Research and Clinical Oncology.2023; 149(8): 5193.     CrossRef
  • Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
    May Nasser Bin-Jumah, Muhammad Shahid Nadeem, Sadaf Jamal Gilani, Bismillah Mubeen, Inam Ullah, Sami I. Alzarea, Mohammed M. Ghoneim, Sultan Alshehri, Fahad A. Al-Abbasi, Imran Kazmi
    Antioxidants.2022; 11(2): 232.     CrossRef
  • Current Status of Antibiotic Stewardship and the Role of Biomarkers in Antibiotic Stewardship Programs
    Chung-Jong Kim
    Infection & Chemotherapy.2022; 54(4): 674.     CrossRef
  • Profile of febrile neutropenia in childhood cancer patients and the clinical utility of procalcitonin and C-reactive protein in identifying severe infections
    Latha Sneha, Sunitha Ramasamy, Vidya Krishna, Uma Sekar, Kopula Sathyamoorthy Sridharan, Shruti Krishna Iyengar, Julius Xavier Scott, Dhaarani Jayaraman
    Sri Ramachandra Journal of Health Sciences.2022; 2: 61.     CrossRef
  • Serum procalcitonin in Philadelphia-negative myeloproliferative neoplasms
    Ivan Krečak, Nena Peran, Ivana Lapić, Velka Gverić-Krečak, Filip Krečak, Pavle Rončević, Nadira Duraković
    Wiener klinische Wochenschrift.2021; 133(1-2): 62.     CrossRef
  • Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia
    Luisa Agnello, Giulia Bivona, Elisa Parisi, Giuseppe Dejan Lucido, Alessandro Iacona, Anna Maria Ciaccio, Rosaria Vincenza Giglio, Ottavio Ziino, Marcello Ciaccio
    Laboratory Medicine.2020; 51(6): 585.     CrossRef
  • Comparison of CRP and procalcitonin for etiological diagnosis of fever during febrile neutropenia in hematology patients- an experience from a tertiary care center in Northern India
    Rohan Halder, Tulika Seth, Pradeep K. Chaturvedi, Priyanka Mishra, Manoranjan Mahapatra, Hara P. Pati, Seema Tyagi, Renu Saxena
    Blood Cells, Molecules, and Diseases.2020; 84: 102445.     CrossRef
  • Procalcitonin as a Diagnostic Marker for Bacteremia in Terminal Cancer Patients
    Jungeun Kim, Youn Seon Choi, Juneyoung Lee, In Cheol Hwang
    Korean Journal of Clinical Geriatrics.2020; 21(1): 16.     CrossRef
  • Utility of procalcitonin as a predictor of bloodstream infections and supportive modality requirements in critically ill cancer patients
    Amanda G. Blouin, Meier Hsu, Martin Fleisher, Lakshmi V. Ramanathan, Stephen M. Pastores
    Clinica Chimica Acta.2020; 510: 181.     CrossRef
  • Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy
    Shanshan Ding, Jun Ma, Xingguo Song, Xiaohan Dong, Li Xie, Xianrang Song, Lisheng Liu
    Journal of Oncology.2020; 2020: 1.     CrossRef
  • Prognostic value of procalcitonin and lipopolysaccharide binding protein in cancer patients with chemotherapy-associated febrile neutropenia presenting to an emergency department
    Ignacio Español-Morales, María Dolores Albaladejo-Otón, Ana Hernando-Holgado, Enrique Jiménez-Santos, Patricia Esteban-Torrella, Pablo Cerezuela-Fuentes, Luis García de Guadiana-Romualdo
    Biochemia medica.2019; 29(1): 57.     CrossRef
  • Combination of sepsis biomarkers may indicate an invasive fungal infection in haematological patients
    Igor Stoma, Igor Karpov, Anatoly Uss, Svetlana Krivenko, Igor Iskrov, Natalia Milanovich, Svetlana Vlasenkova, Irina Lendina, Kristina Belyavskaya, Veronika Cherniak
    Biomarkers.2019; 24(4): 401.     CrossRef
  • Serum procalcitonin as an independent diagnostic markers of bacteremia in febrile patients with hematologic malignancies
    Mina Yang, Seung Jun Choi, Jaewoong Lee, Dong Gun Lee, Yoon-Joo Kim, Yeon-Joon Park, Eun-Jee Oh, Senthilnathan Palaniyandi
    PLOS ONE.2019; 14(12): e0225765.     CrossRef
  • Presepsin as a diagnostic marker of bacterial infections in febrile neutropenic pediatric patients with hematological malignancies
    Ahmad Baraka, Marwa Zakaria
    International Journal of Hematology.2018; 108(2): 184.     CrossRef
  • Diagnostic value of sepsis biomarkers in hematopoietic stem cell transplant recipients in a condition of high prevalence of gram-negative pathogens
    Igor Stoma, Igor Karpov, Anatoly Uss, Oleg Rummo, Natalia Milanovich, Igor Iskrov
    Hematology/Oncology and Stem Cell Therapy.2017; 10(1): 15.     CrossRef
  • Comparison of diagnostic and prognostic utility of lactate and procalcitonin for sepsis in adult cancer patients presenting to emergency department with systemic inflammatory response syndrome
    Esra Keçe, Elif Yaka, Serkan Yılmaz, Nurettin Özgür Doğan, Cansu Alyeşil, Murat Pekdemir
    Turkish Journal of Emergency Medicine.2016; 16(1): 1.     CrossRef
  • The diagnostic value of soluble urokinase plasminogen activator receptor compared with C-reactive protein and procalcitonin in children with febrile neutropenia
    Melis Sirinoglu, Ahmet Soysal, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Ismail Cinel, Ahmet Koç, Gülnur Tokuç, Ali Yaman, Goncagül Haklar, Önder Şirikçi, Serap Turan, Gülşen Altınkanat Gelmez, Güner Söyletir, Mustafa Bakır
    Pediatric Hematology and Oncology.2016; 33(3): 200.     CrossRef
  • Initial procalcitonin level predicts infection and its outcome in patients with non-Hodgkin lymphoma with febrile neutropenia
    Xiao Liu, Dao Feng Wang, Yi Fang, Wen Feng Ye, Shu Liu, Ning Lou
    Leukemia & Lymphoma.2015; 56(1): 85.     CrossRef
  • Value of lipopolysaccharide binding protein as diagnostic marker of infection in adult cancer patients with febrile neutropenia: comparison with C-reactive protein, procalcitonin, and interleukin 6
    Luis García de Guadiana-Romualdo, Ignacio Español-Morales, Pablo Cerezuela-Fuentes, Luciano Consuegra-Sánchez, Ana Hernando-Holgado, Patricia Esteban-Torrella, Enrique Jiménez-Santos, Monserrat Viqueira-González, África de Béjar-Almira, María Dolores Alba
    Supportive Care in Cancer.2015; 23(7): 2175.     CrossRef
  • Adrenomedullin—A New Marker in Febrile Neutropenia: Comparison With CRP and Procalcitonin
    Metin Demirkaya, Deniz Tugcu, Arzu Akcay, Gönül Aydogan, Ferhan Akıcı, Zafer Salcioglu, Hakan Ekmekci, Betül Sevinir, Ozlem Balci Ekmekci
    Pediatric Hematology and Oncology.2015; 32(7): 482.     CrossRef
  • Utilización de procalcitonina y proteína C reactiva como marcadores de infección en la neutropenia febril de pacientes sometidos a trasplante de progenitores hematopoyéticos
    Marina Sánchez-Yepes, Eduardo Aznar-Oroval, Pablo Lorente-Alegre, Tomás García-Lozano, Isabel Picón-Roig, Pilar Pérez-Ballestero, Blanca Ortiz-Muñoz
    Enfermedades Infecciosas y Microbiología Clínica.2014; 32(7): 418.     CrossRef
  • Predictive factors of bacteremia in patients with febrile urinary tract infection: an experience at a tertiary care center
    H. Lee, Y.-S. Lee, R. Jeong, Y.-J. Kim, S. Ahn
    Infection.2014; 42(4): 669.     CrossRef
  • Differential diagnosis between bacterial infection and neoplastic fever in patients with advanced urological cancer: The role of procalcitonin
    Hiroshi Yaegashi, Kouji Izumi, Yasuhide Kitagawa, Yoshifumi Kadono, Hiroyuki Konaka, Atsushi Mizokami, Mikio Namiki
    International Journal of Urology.2014; 21(1): 104.     CrossRef
  • Utilidad de la procalcitonina para predecir bacteriemia en pacientes oncológicos con fiebre
    Enrique Jiménez-Santos, Ana Hernando-Holgado, Luis García de Guadiana-Romualdo, Monserrat Viqueira-González, Pablo Cerezuela Fuentes, Ignacio Español Morales
    Revista del Laboratorio Clínico.2014; 7(4): 127.     CrossRef
  • The Utility of Proadrenomedullin and Procalcitonin in Comparison to C-Reactive Protein as Predictors of Sepsis and Bloodstream Infections in Critically Ill Patients With Cancer*
    Labib Debiane, Ray Y. Hachem, Iba Al Wohoush, William Shomali, Ramez R. Bahu, Ying Jiang, Anne-Marie Chaftari, Joseph Jabbour, Munirah Al Shuaibi, Alexander Hanania, S. Egbert Pravinkumar, Philipp Schuetz, Issam Raad
    Critical Care Medicine.2014; 42(12): 2500.     CrossRef
  • Utility of C-Reactive Protein and Procalcitonin for Detecting Bloodstream Infection in Patients with HIV/AIDS
    Arianna Castillo Marshall, Tersilia García Castellanos, Isabel Martínez Motas, Daniel Salazar Rodriguez, María Eugenia Toledo Romaní, Jorge Pérez Ávila
    World Journal of AIDS.2014; 04(03): 287.     CrossRef
  • The Use of Procalcitonin in Clinical Practice
    Clementine YF Yap, Tar Choon Aw
    Proceedings of Singapore Healthcare.2014; 23(1): 33.     CrossRef
  • Is Procalcitonin Reduction Indicative of Immunomodulation in Septic Patients Treated with Hemodialysis with High Cutoff Membrane?
    Gianluca Villa, Paola Di Maggio, A. Raffaele De Gaudio
    Blood Purification.2014; 38(2): 100.     CrossRef
  • Utilidad de la procalcitonina en la detección de bacteriemia en los pacientes con cáncer
    E. Aznar-Oroval, M. Sánchez-Yepes, T. García-Lozano, B. Ortiz-Muñoz, P. Pérez-Ballestero
    Revista Clínica Española.2013; 213(5): 267.     CrossRef
  • The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of use for identifying low-risk febrile neutropenic cancer patients
    Jean Klastersky, Marianne Paesmans
    Supportive Care in Cancer.2013; 21(5): 1487.     CrossRef
  • Diagnostic Value and Prognostic Significance of Pleural C-Reactive Protein in Lung Cancer Patients with Malignant Pleural Effusions
    Do-Sim Park, Dong Kim, Ki-Eun Hwang, Yu-Ri Hwang, Chul Park, Chang-Hwan Seol, Kyung-Hwa Cho, Byoung-Ryun Kim, Seong-Hoon Park, Eun-Taik Jeong, Hak-Ryul Kim
    Yonsei Medical Journal.2013; 54(2): 396.     CrossRef
  • Streamlining antibiotic therapy with procalcitonin protocols: consensus and controversies
    Sebastian Haubitz, Beat Mueller, Philipp Schuetz
    Expert Review of Respiratory Medicine.2013; 7(2): 145.     CrossRef
  • The significance of serum urokinase plasminogen activation receptor (suPAR) in the diagnosis and follow-up of febrile neutropenic patients with hematologic malignancies
    Selçuk Kaya, Iftihar Köksal, Ahmet Menteşe, Mehmet Sönmez, Ayşegül Sümer, Seval Sönmez Yıldırım, Gürdal Yılmaz
    International Journal of Infectious Diseases.2013; 17(11): e1056.     CrossRef
  • Procalcitonin in sepsis and bacterial infections
    Abhijit Chaudhury, G.L. Sachin Sumant, R. Jayaprada, Usha Kalawat, B.V. Ramana
    Journal of Clinical & Scientific Research.2013; 2(4): 216.     CrossRef
  • Procalcitonin as a marker of infection in febrile neutropenia: A systematic review
    Anders K. Boysen, Bettina R. Jensen, Laurids Ø. Poulsen, Paw Jensen, Søren Ladefoged
    Modern Chemotherapy.2013; 02(01): 8.     CrossRef
  • Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?
    William Shomali, Ray Hachem, Anne‐Marie Chaftari, Ying Jiang, Ramez Bahu, Joseph Jabbour, Sammy Raad, Munirah Al Shuaibi, Iba Al Wohoush, Issam Raad
    Cancer.2012; 118(23): 5823.     CrossRef
  • Allergic Airway Inflammation Initiates Long-Term Vascular Remodeling of the Pulmonary Circulation
    Kristina Rydell-Törmänen, Lena Uller, Jonas S. Erjefält
    International Archives of Allergy and Immunology.2009; 149(3): 251.     CrossRef
  • 12,979 View
  • 152 Download
  • 37 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP