- Gastrointestinal Cancer
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Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies
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Soo Young Hwang, Kwanghyun Kim, Byeonggwan Ha, Dongkyu Lee, Seonung Kim, Seongjun Ryu, Jisu Yang, Sun Jae Jung
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Cancer Res Treat. 2021;53(4):1134-1147. Published online March 17, 2021
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DOI: https://doi.org/10.4143/crt.2020.1191
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 Abstract
 PDF Supplementary Material PubReader ePub
- Purpose
Chemotherapy-related cognitive impairment (CRCI) is a controversial concept not much explored on colorectal cancer patients.
Materials and Methods
We identified 11 prospective studies: eight studies on 696 colorectal cancer patients who received chemotherapy and three studies on 346 rectal cancer patients who received neoadjuvant chemoradiotherapy. Standardized mean differences (SMDs) of neuropsychological test results and the cognitive quality-of-life scale were calculated using random effect models. A meta-regression was conducted to investigate the association between mean study population age and effect sizes.
Results
The association between chemotherapy and cognitive impairment was not clear in colorectal cancer patients (SMD, 0.003; 95% confidence interval, ‒0.080 to 0.086). However, a meta-regression showed that older patients are more vulnerable to CRCI than younger patients (β=‒0.016, p < 0.001).
Conclusion
Chemotherapy has an overall positive negligible effect size on the cognitive function of colorectal patients. Age is a significant moderator of CRCI.
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Citations
Citations to this article as recorded by  - Research Progress: Exploring the Long-term Survival Status of Colorectal Cancer Survivors
Zhaobei Cai, Qianqian Chen, Enqiang Linghu
Clinical Cancer Investigation Journal.2024; 13(2): 34. CrossRef - Neurocognitive function and quality-of-life in patients with colorectal cancer
Ann M. Berger, Jean Grem, Matthew Garlinghouse, Elizabeth Lyden, Kendra Schmid
European Journal of Oncology Nursing.2023; 64: 102304. CrossRef - The impact of chemotherapy on cognitive performance post‐surgery in patients with colorectal cancer: A prospective cohort study
Marie‐Rose Dwek, Stanton P. Newman, Stefano Brini, Pru Holder, Michael Machesney, David Propper, Lorna R. Rixon, Shashivadan P. Hirani, Catherine S. Hurt
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Journal of Medical Internet Research.2023;[Epub] CrossRef - Long-term neurocognitive function after whole-brain radiotherapy in patients with melanoma brain metastases in the era of immunotherapy
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Strahlentherapie und Onkologie.2022; 198(10): 884. CrossRef - Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting‐state functional magnetic resonance imaging study
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Frontiers in Oncology.2022;[Epub] CrossRef - Neurological Complications of Conventional and Novel Anticancer Treatments
Paola Alberti, Alessandro Salvalaggio, Andreas A. Argyriou, Jordi Bruna, Andrea Visentin, Guido Cavaletti, Chiara Briani
Cancers.2022; 14(24): 6088. CrossRef - Effect of chemotherapy and radiotherapy on cognitive impairment in colorectal cancer: evidence from Korean National Health Insurance Database Cohort
Kwanghyun Kim, Chang Woo Kim, Aesun Shin, Hyunseok Kang, Sun Jae Jung
Epidemiology and Health.2021; 43: e2021093. CrossRef
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