Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Author index

Page Path
HOME > Browse articles > Author index
Search
Sang-Jeong Ahn 2 Articles
Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)–Positive Breast Cancers
So Jeong Lee, Cheong-Soo Hwang, Young-Keum Kim, Hyun Jung Lee, Sang-Jeong Ahn, Nari Shin, Jung Hee Lee, Dong Hoon Shin, Kyung Un Choi, Do Youn Park, Chang Hun Lee, Gi Young Huh, Mi Young Sol, Hee Jin Lee, Gyungyub Gong, Jee Yeon Kim, Ahrong Kim
Cancer Res Treat. 2017;49(2):313-321.   Published online July 7, 2016
DOI: https://doi.org/10.4143/crt.2016.098
AbstractAbstract PDFPubReaderePub
Purpose
The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been determined in breast cancers. Interferons can affect T-cell activity through direct and indirect mechanisms. Myxovirus resistance A (MxA) is an excellent marker of interferon activity. Here,we evaluated TILs and MxA expression in human epidermal growth factor receptor 2 (HER2)–positive breast cancers.
Materials and Methods
Ninety cases of hormone receptor (HR)+/HER2+ tumors and 78 cases of HR–/HER2+ tumors were included. The TILs level was assessed using hematoxylin and eosin–stained full face sections, and MxA expressionwas evaluated by immunohistochemistrywith a tissue microarray.
Results
MxA protein expression was significantly higher in tumors with high histologic grade (p=0.023) and high levels of TILs (p=0.002). High levels of TILs were correlated with high histological grade (p=0.001), negative lymphovascular invasion (p=0.007), negative lymph node metastasis (p=0.007), absence of HR expression (p < 0.001), abundant tertiary lymphoid structures (TLSs) around ductal carcinoma in situ (p=0.018), and abundant TLSs around the invasive component (p < 0.001). High levels of TILs were also associated with improved disease-free survival, particularly in HR–/HER2+ breast cancers. However, MxA was not a prognostic factor.
Conclusion
High expression of MxA in tumor cells was associated with high levels of TILs in HER2-positive breast cancers. Additionally, a high level of TILs was a prognostic factor for breast cancer, whereas the level of MxA expression had no prognostic value.

Citations

Citations to this article as recorded by  
  • Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors
    Mart van Rijthoven, Simon Obahor, Fabio Pagliarulo, Maries van den Broek, Peter Schraml, Holger Moch, Jeroen van der Laak, Francesco Ciompi, Karina Silina
    Communications Medicine.2024;[Epub]     CrossRef
  • The roles of tertiary lymphoid structures in chronic diseases
    Yuki Sato, Karina Silina, Maries van den Broek, Kiyoshi Hirahara, Motoko Yanagita
    Nature Reviews Nephrology.2023; 19(8): 525.     CrossRef
  • NFIC1 suppresses migration and invasion of breast cancer cells through interferon-mediated Jak-STAT pathway
    Jing Zhang, Mingyue Fan, Chanjuan Jin, Zhaoying Wang, Yutong Yao, Yueru Shi, Xin Hu, Youzhong Wan
    Archives of Biochemistry and Biophysics.2022; 727: 109346.     CrossRef
  • Low MxA Expression Predicts Better Immunotherapeutic Outcomes in Glioblastoma Patients Receiving Heat Shock Protein Peptide Complex 96 Vaccination
    Yi Wang, Chunzhao Li, Xiaohan Chi, Xijian Huang, Hua Gao, Nan Ji, Yang Zhang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer
    Abrar I. Aljohani, Chitra Joseph, Sasagu Kurozumi, Omar J. Mohammed, Islam M. Miligy, Andrew R. Green, Emad A. Rakha
    Breast Cancer Research and Treatment.2020; 181(3): 541.     CrossRef
  • Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers
    Miseon Lee, In Hye Song, Sun-Hee Heo, Young-Ae Kim, In Ah Park, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee
    Cancer Research and Treatment.2019; 51(1): 80.     CrossRef
  • Grade II/III Glioma Microenvironment Mining and Its Prognostic Merit
    Jiawei Chen, Chongxian Hou, Peng Wang, Yong Yang, Dong Zhou
    World Neurosurgery.2019; 132: e76.     CrossRef
  • Programmed death-ligand 1 (PD-L1) expression in tumour cell and tumour infiltrating lymphocytes of HER2-positive breast cancer and its prognostic value
    Ahrong Kim, So Jeong Lee, Young Keum Kim, Won Young Park, Do Youn Park, Jee Yeon Kim, Chang Hun Lee, Gyungyub Gong, Gi Yeong Huh, Kyung Un Choi
    Scientific Reports.2017;[Epub]     CrossRef
  • 11,386 View
  • 272 Download
  • 8 Web of Science
  • 8 Crossref
Close layer
Venous Invasion in Colorectal Cancer: Impact of Morphologic Findings on Detection Rate
Chungsu Hwang, Sojeong Lee, Ahrong Kim, Young-Geum Kim, Sang-Jeong Ahn, Do Youn Park
Cancer Res Treat. 2016;48(4):1222-1228.   Published online February 12, 2016
DOI: https://doi.org/10.4143/crt.2015.429
AbstractAbstract PDFPubReaderePub
Purpose
Venous invasion (VI) is widely accepted as a poor prognostic factor in colorectal cancer (CRC), and is indicated as a high-risk factor determining the use of adjuvant chemotherapy in CRC. However, there is marked interobserver and intraobserver variability in VI identification and marked variability in the real prevalence of VI in CRC.
Materials and Methods
We investigated the detection rate of VI in 93 consecutive cases of T3 or T4 CRC based on the following: original pathology report, review of hematoxylin and eosin (H&E) slides with attention to the “protruding tongue” and “orphan arteriole” signs, and elastic stain as the gold standard.
Results
Overall, the detection rate of VI was significantly increased as follows: 14/93 (15.1%) in the original pathology report, 38/93 (40.9%) in review of H&E slides with attention to the “protruding tongue” and “orphan arteriole” signs, and 45/93 (48.4%) using elastic stain. VI detection based on morphologic features showed 77.8% sensitivity and 91.1% specificity and showed a linear correlation (Spearman correlation coefficient, 0.727; p < 0.001) with VI detected by elastic stain. In addition, improved agreement between detection methods (detection on the basis of morphologic features, κ=0.719 vs. original pathology report, κ=0.318) was observed using kappa statistics.
Conclusion
Slide review with special attention to the “protruding tongue” and “orphan arteriole” signs could be used for better identification of VI in CRC in routine surgical practice.

Citations

Citations to this article as recorded by  
  • Usefulness of Elastica van Gieson staining and the number of samples prepared for venous invasion of colorectal cancer (pT2–pT4)
    Kota Nakashima, Jun Akiba, Shinji Mizuochi, Masamichi Nakayama, Naohiro Yoshida, Kenichi Koushi, Takefumi Yoshida, Fumihiko Fujita, Hitoshi Obara, Tatsuyuki Kakuma, Yoshito Akagi, Hirohisa Yano
    Human Pathology Reports.2023; 31: 300690.     CrossRef
  • Routine elastin staining improves venous invasion detection in colorectal carcinoma
    Hisham F. Bahmad, Ferial Alloush, Ali Salami, Rachel Sawah, Ciara Lusnia, Ekim Kilinc, Tyson Sutherland, Sarah Alghamdi, Robert J. Poppiti
    Annals of Diagnostic Pathology.2023; 66: 152170.     CrossRef
  • The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer
    Jeffrey Gonzalez, Hisham F. Bahmad, Stephanie Ocejo, Alvaro Abreu, Meagan Popp, Samantha Gogola, Vielka Fernandez, Monica Recine, Robert Poppiti
    International Journal of Molecular Sciences.2023; 24(20): 15264.     CrossRef
  • Reevaluation of Venous Invasion with Elastic Tissue Stain in Colorectal Cancers
    Ebru AKAY, Serdal Sadet ÖZCAN, Merve DOĞAN, Fatoş TEKELİOĞLU, Saliha KARAGÖZ EREN, Hatice KARAMAN
    Sakarya Medical Journal.2022;[Epub]     CrossRef
  • Addition of V-Stage to Conventional TNM Staging to Create the TNVM Staging System for Accurate Prediction of Prognosis in Colon Cancer: A Multi-Institutional Retrospective Cohort Study
    Jung Hoon Bae, Ji Hoon Kim, Jaeim Lee, Bong-Hyeon Kye, Sang Chul Lee, In Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Yoon Suk Lee
    Biomedicines.2021; 9(8): 888.     CrossRef
  • Feasibility and Performance of Elastin Trichrome as a Primary Stain in Colorectal Cancer Resection Specimens
    Sameer Shivji, Ipshita Kak, Stephanie L. Reid, Jennifer Muir, Sara Hafezi-Bakhtiari, Hector Li-Chang, Ardit Deliallisi, Ken J. Newell, Andrea Grin, James Conner, Richard Kirsch
    American Journal of Surgical Pathology.2021; 45(10): 1419.     CrossRef
  • Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study
    Jung Hoon Bae, Ji Hoon Kim, Bong-Hyeon Kye, Abdullah Al-Sawat, Chul Seung Lee, Seung-Rim Han, In Kyu Lee, Sung Hak Lee, Yoon Suk Lee
    Frontiers in Surgery.2021;[Epub]     CrossRef
  • Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion
    Seung-Mo Hong, DongJun Jung, Ashley Kiemen, Matthias M. Gaida, Tadashi Yoshizawa, Alicia M. Braxton, Michaël Noë, Gemma Lionheart, Kiyoko Oshima, Elizabeth D. Thompson, Richard Burkhart, Pei-Hsun Wu, Denis Wirtz, Ralph H. Hruban, Laura D. Wood
    Modern Pathology.2020; 33(4): 639.     CrossRef
  • Prognostic significance of venous invasion in node‐negative head and neck squamous cell carcinoma
    Arun Gopinath, Aysha Mubeen, Brett Baskovich, Ibraheem Mohammed, Raafat Makary, Erica S. Hoy, Roi Dagan, Carmen Smotherman, Shiva Gautam, Rui P. Fernandes, Anthony M. Bunnell, Phillip Pirgousis, Ahmad Alkhasawneh
    Journal of Oral Pathology & Medicine.2020; 49(2): 150.     CrossRef
  • Comparison of the efficiency of transgelin, smooth muscle myosin, and CD31 antibodies for the assessment of vascular tumor invasion and free tumor deposits in gastric, pancreatic, and colorectal adenocarcinomas
    Betul Ogut, Ozgur Ekinci, Bulent Celik, EmelRodoplu Unal, Ayse Dursun
    Indian Journal of Pathology and Microbiology.2020; 63(1): 25.     CrossRef
  • Elastin and collagen IV double staining: A refined method to detect blood vessel invasion in breast cancer
    Masayoshi Fujisawa, Masako Omori, Hiroyoshi Doihara, Ye‐Min Than, Hnin Wint Wint Swe, Teizo Yoshimura, Akihiro Matsukawa
    Pathology International.2020; 70(9): 612.     CrossRef
  • Incidence of extramural venous invasion in colorectal carcinoma as determined at the invasive tumor front and its prognostic impact
    Klaus Dirschmid, William Sterlacci, Ewald Wöll, Peter Tschann, Michaela Rhomberg, Felix Offner
    Human Pathology.2019; 86: 102.     CrossRef
  • Why is pancreatic cancer so deadly? The pathologist's view
    Ralph H Hruban, Matthias M Gaida, Elizabeth Thompson, Seung‐Mo Hong, Michaël Noë, Lodewijk AA Brosens, Martine Jongepier, G Johan A Offerhaus, Laura D Wood
    The Journal of Pathology.2019; 248(2): 131.     CrossRef
  • Rectal cancer and the pathologist
    Mariana Berho, Pablo A. Bejarano
    Minerva Chirurgica.2018;[Epub]     CrossRef
  • Identifying molecular contributors to autofluorescence of neoplastic and normal colon sections using excitation-scanning hyperspectral imaging
    Joshua Deal, Sam Mayes, Craig Browning, Shante Hill, Paul Rider, Carole Boudreaux, Thomas C. Rich, Silas J. Leavesley
    Journal of Biomedical Optics.2018; 24(02): 1.     CrossRef
  • 12,690 View
  • 229 Download
  • 14 Web of Science
  • 15 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP