Cancer Research and Treatment

Pengcheng Zhu

2 Articles

Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review: Pengcheng Zhu, Yaqi Duan, Qilin Ao, Guoping Wang; Cancer Res Treat. 2018;50(4):1452-1457. Published online November 24, 2017; DOI: https://doi.org/10.4143/crt.2017.414

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear), and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary. Therefore, a diagnosis of MCST of the right testicle was determined. To the best of our knowledge, this is the first case of MCST occurring in the testicles. The study may provide new insights to the tumor biology of MCST and a better understanding of this rare entity.

Citations

Citations to this article as recorded by

Ovarian Microcystic Stromal Tumor with Significant Nestin Expression: A Unique Case
Bao Wu, Chongming Wu, Dandan Li, Zhanmin Yang, Ying Liu, Hai-Xia Zhang, Hong-Wu Xin, Yuqin Bai
Internal Medicine.2024; 63(20): 2781. CrossRef
Microcystic stromal tumour of testis
Marije Hoogland, Ivar Bleumer, Albert Suurmeijer
BMJ Case Reports.2022; 15(3): e248498. CrossRef
A Morphologic and Immunohistochemical Comparison of Nuclear β-Catenin Expressing Testicular Sertoli Cell Tumors and Pancreatic Solid Pseudopapillary Neoplasms Supporting Their Continued Separate Classification
Chia-Sui Kao, Thomas M. Ulbright
American Journal of Surgical Pathology.2020; 44(8): 1082. CrossRef
Solid pseudopapillary neoplasm (SPN) of the testis: Comprehensive mutational analysis of 6 testicular and 8 pancreatic SPNs
Kvetoslava Michalova, Michael Michal, Monika Sedivcova, Dmitry V. Kazakov, Carlos Bacchi, Tatjana Antic, Marketa Miesbauerova, Ondrej Hes, Michal Michal
Annals of Diagnostic Pathology.2018; 35: 42. CrossRef

8,616 View
195 Download
4 Web of Science
4 Crossref

Erdheim-Chester Disease with Emperipolesis: A Unique Case Involving the Heart: Pengcheng Zhu, Naping Li, Lu Yu, Mariajose Navia Miranda, Guoping Wang, Yaqi Duan; Cancer Res Treat. 2017;49(2):553-558. Published online July 28, 2016; DOI: https://doi.org/10.4143/crt.2016.078

Abstract PDF PubReader ePub

Histiocytosis is an uncommon disease characterized by excessive accumulation of histiocytes. Here, we report a rare case of non-Langerhans-cell histiocytosis in a 51- year-old woman who presented with severe symptoms of pericardial effusion. Radiologic investigation also detected multiple bone (lower limbs, vertebrae, ribs, and ilium) lesions. Resected pericardium showed abundant mono- or multi-nucleated non-foamy histiocytes (CD68⁺/CD163⁺/S-100⁺/CD1α⁻/langerin⁻) in a fibroinflammatory background. The histiocytes demonstrated emperipolesis of lymphocytes, a hallmark feature of Rosai-Dorfman disease (RDD). However, molecular analysis revealed a BRAF V600E mutation of the proliferating histiocytes, highlighting the neoplastic features frequently observed in another non-Langerhans-cell histiocytosis known as Erdheim-Chester Disease (ECD). We consider this case to be a unique presentation of ECD harboring some RDD-like cells with emperipolesis, but not a case of RDD with a BRAF mutation concerning its clinical manifestation (involvement of the heart and bones) and neoplastic features.

Citations

Citations to this article as recorded by

An Autopsied Case of Erdheim-Chester Disease with Severe Cardiovascular Involvement
Atsushi Matsunashi, Wang Zhipeng, Akihiko Sugimoto, Masakazu Fujimoto, Akihiko Yoshizawa, Ryo Sakamoto, Michihiro Uyama, Kohei Ikezoe, Kiminobu Tanizawa, Tomohiro Handa, Toyohiro Hirai
Internal Medicine.2025;[Epub] CrossRef
Infantile Rosai-Dorfman Disease With Isolated Brain Lesions Disseminated to the Parenchyma and Intraventricular Ependyma, Alteration of Leukocytes as a Promotion Factor in Immune Defense, and New Proposals: A Case Report and Literature Review
Nasser Kamalian, Shahmir Kamalian, Mohammad Vasei
Cureus.2024;[Epub] CrossRef
Emperipolesis in pleural fluid mesothelial cells . A phenomenon not associated with Rosai-Dorfman disease, report of a case
Diana Sofía Vargas-Lías, Mónica Lizette Serrano-Arévalo, Lara-Torres César, Corredor-Alonso Guillermo Ernesto, Hugo R. Dominguez-malagon
Ultrastructural Pathology.2024; 48(5): 438. CrossRef
BRAF V600E mutation and high expression of PD-L1 in Rosai-Dorfman disease: case report and review of the literature
Farnoush M. Moen, Mariam M. Youssef, Mihir Shukla, Mary Lynn Nierodzik, Marius E. Mayerhoefer, Christopher Park
Journal of Hematopathology.2024;[Epub] CrossRef
Characterizing Rosai-Dorfman disease with [18F]FDG PET/CT: a retrospective analysis of a single-center study
Jianan Zhang, Ruixue Cui, Jian Li, Xinxin Cao, Yaping Luo
European Radiology.2023; 33(9): 6492. CrossRef
Atypical skeletal involvement in patients with Erdheim–Chester disease: CT imaging findings
Zaizhu Zhang, Wei Yu, Wenmin Guan, Qiang Lin, Ali Guermazi
Orphanet Journal of Rare Diseases.2022;[Epub] CrossRef
BRAF mutation in overlapping form of Erdheim-Chester and Rosai Dorfman diseases: a unique case restricted to the central nervous system
J. Dufour, B. Mathon, M. Touat, K. Hoang-Xuan, K. Mokhtari, A. Idbaih
Revue Neurologique.2021; 177(6): 708. CrossRef
Reticulohistiocytoses: a revision of the full spectrum
A. Bonometti, E. Berti
Journal of the European Academy of Dermatology and Venereology.2020; 34(8): 1684. CrossRef
Orbital histiocytosis with systemic involvement
Joaquín J.R. Civit, Davinia Godoy, Alicia Conde, Jorge Arencibia, Ramón Medel, Miguel A. Limeres, Iñigo S. Miguel, José D. Marín, Y. Aguilar, Francesc Tresserra, Francisco Medina
Saudi Journal of Ophthalmology.2020; 34(4): 319. CrossRef
Coccidioidomycosis with emperipolesis in fine needle aspiration
Alexandra Grosse, Claudia Grosse
Cytopathology.2019; 30(4): 451. CrossRef
Bilateral Renal Colic as an Initial Presentation of Erdheim-Chester Disease
Julien Sarkis, Fady Haddad, Sarah Nasr, Elie Hanna, Ahmad Mroueh, Elie Nemr
Case Reports in Urology.2019; 2019: 1. CrossRef
Erdheim–Chester disease: description of two illustrative cases involving the lung
Magda Zanelli, Maxwell Smith, Maria C Mengoli, Lucia Spaggiari, Loredana De Marco, Filippo Lococo, Francesco Puma, Stefano Ascani
Histopathology.2018; 73(1): 167. CrossRef

11,453 View
223 Download
11 Web of Science
12 Crossref

Author index