Cancer Research and Treatment

Peng Zhang

2 Articles

Body Composition Predicts Survival in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: Neehar D. Parikh, Peng Zhang, Amit G. Singal, Brian A. Derstine, Venkat Krishnamurthy, Pranab Barman, Akbar K. Waljee, Grace L. Su; Cancer Res Treat. 2018;50(2):530-537. Published online June 1, 2017; DOI: https://doi.org/10.4143/crt.2017.156

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Purpose
The prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is often uncertain. We aimed to utilize analytic morphomics, a high-throughput imaging analysis, to assess if body composition is predictive of post-TACE survival.
Materials and Methods
We included patients from a single center (Ann Arbor VA)who had TACE as the primary treatment forHCC and had a pre-treatment computed tomography scans. Univariate analysis and multivariate conditional inference tree analysis were utilized to identify the morphomic characteristics predictive of 1-year survival. Resultswere validated in an external cohort(University of MichiganHealth System) ofHCC patientswho underwent TACE as their primary treatment.
Results
In the 75 patients in the derivation cohort, median survival was 439 (interquartile range, 377 to 685) days from receipt of TACE, with 1-year survival of 61%. Visceral fat density (VFD) was the only morphomic factor predictive of overall and 1-year survival (p < 0.001). Patients with VFD above the 56th percentile had a 1-year survival of 39% versus 78% for those below the 56th percentile. VFD also correlated with 1-year survival in the external validation cohort (44% vs. 72%, p < 0.001). In a secondary analysis, patients with higher VFD were significantly more likely to experience hepatic decompensation after TACE (p < 0.001).
Conclusion
VFD served as an objective predictor of mortality in patients undergoing TACE, possibly through its ability to predict hepatic decompensation. VFD may serve as a radiographic biomarker in predicting TACE outcomes.

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Impact of body composition on the prognosis of hepatocellular carcinoma patients treated with transarterial chemoembolization: A systematic review and meta-analysis
Anrong Wang, Junfeng Li, Changfeng Li, Hui Zhang, Yingfang Fan, Kuansheng Ma, Qiang Wang
Heliyon.2024; 10(3): e25237. CrossRef
Incorporation of quantitative imaging data using artificial intelligence improves risk prediction in veterans with liver disease
Grace L. Su, Peng Zhang, Patrick X. Belancourt, Bradley Youles, Binu Enchakalody, Ponni Perumalswami, Akbar Waljee, Sameer Saini
Hepatology.2024; 80(4): 928. CrossRef
Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer
Valerie Gunchick, Edward Brown, Juan Liu, Jason W. Locasale, Philip A. Philip, Stewart C. Wang, Grace L. Su, Vaibhav Sahai
JAMA Network Open.2024; 7(10): e2440047. CrossRef
Role of tumor-specific and whole-body imaging biomarkers for prediction of recurrence in patients with stage III colorectal cancer
Amir A. Borhani, Peng Zhang, Brenda Diergaarde, Sophie Darwiche, Kalina Chuperlovska, Stewart C. Wang, Robert E. Schoen, Grace L. Su
Abdominal Radiology.2024;[Epub] CrossRef
Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts
Berend R. Beumer, Kosei Takagi, Stefan Buettner, Yuzo Umeda, Takahito Yagi, Toshiyoshi Fujiwara, Jeroen L.A. van Vugt, Jan N.M. IJzermans
International Journal of Surgery.2023; 109(8): 2258. CrossRef
Clinical-radiomics predictors to identify the suitability of transarterial chemoembolization treatment in intermediate-stage hepatocellular carcinoma: A multicenter study
Dan-Dan Wang, Jin-Feng Zhang, Lin-Han Zhang, Meng Niu, Hui-Jie Jiang, Fu-Cang Jia, Shi-Ting Feng
Hepatobiliary & Pancreatic Diseases International.2023; 22(6): 594. CrossRef
Impact of body composition in advanced hepatocellular carcinoma: A subanalysis of the SORAMIC trial
Alexey Surov, Maximilian Thormann, Mattes Hinnerichs, Max Seidensticker, Ricarda Seidensticker, Osman Öcal, Kerstin Schütte, Christoph J. Zech, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Chris Verslype, Bernhard Gebauer, Christian Sengel, Iren
Hepatology Communications.2023;[Epub] CrossRef
Adipose distribution patterns as prognostic factors in patients with HCC: A systematic review and meta-analysis
Shuo Shi, Haiyan Yi, Yi Zheng, Yuxuan Zhao, Dexin Yu
European Journal of Radiology.2023; 167: 111025. CrossRef
Preoperative Pectoralis Muscle Index Predicts Distant Metastasis-Free Survival in Breast Cancer Patients
Wen-juan Huang, Meng-lin Zhang, Wen Wang, Qing-chun Jia, Jia-rui Yuan, Xin Zhang, Shuang Fu, Yu-xi Liu, Shi-di Miao, Rui-tao Wang
Frontiers in Oncology.2022;[Epub] CrossRef
Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease
Wei Zhang, Grace L Su, Kaza Sravanthi, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Anna S Lok
JGH Open.2022; 6(8): 519. CrossRef
Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria
Berend R. Beumer, Jeroen L.A. van Vugt, Gonzalo Sapisochin, Peter Yoon, Marco Bongini, Di Lu, Xiao Xu, Paolo De Simone, Lorenzo Pintore, Nicolas Golse, Malgorzata Nowosad, William Bennet, Emmanouil Tsochatzis, Evangelia Koutli, Fariba Abbassi, Marco P.A.W
Journal of Cachexia, Sarcopenia and Muscle.2022; 13(5): 2373. CrossRef
Bone Densities Assessed by Hounsfield Units at L5 in Computed Tomography Image Independently Predict Hepatocellular Carcinoma Development in Cirrhotic Patients
Christopher Yeh, Ming-Wei Lai, Chau-Ting Yeh, Yang-Hsiang Lin, Jeng-Hwei Tseng
Journal of Clinical Medicine.2022; 11(19): 5562. CrossRef
What Is the Role of Body Composition Assessment in HCC Management?
Pompilia Radu, Maryam Ebadi, Aldo J. Montano-Loza, Jean Francois Dufour
Cancers.2022; 14(21): 5290. CrossRef
High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma
Leona von Hessen, Marie Roumet, Martin Helmut Maurer, Naomi Lange, Helen Reeves, Jean‐François Dufour, Pompilia Radu
Liver International.2021; 41(4): 828. CrossRef
Automated Measurements of Body Composition in Abdominal CT Scans Using Artificial Intelligence Can Predict Mortality in Patients With Cirrhosis
Winnie Y. Zou, Binu E. Enchakalody, Peng Zhang, Nidhi Shah, Sameer D. Saini, Nicholas C. Wang, Stewart C. Wang, Grace L. Su
Hepatology Communications.2021; 5(11): 1901. CrossRef
The role of muscle depletion and visceral adiposity in HCC patients aged 65 and over undergoing TACE
Jihye Lim, Kyung Won Kim, Yousun Ko, Il-Young Jang, Yung Sang Lee, Young-Hwa Chung, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Jonggi Choi, Danbi Lee
BMC Cancer.2021;[Epub] CrossRef
Morphomic Signatures Derived from Computed Tomography Predict Hepatocellular Carcinoma Occurrence in Cirrhotic Patients
Kung-Hao Liang, Peng Zhang, Chih-Lang Lin, Stewart C. Wang, Tsung-Hui Hu, Chau-Ting Yeh, Grace L. Su
Digestive Diseases and Sciences.2020; 65(7): 2130. CrossRef
Visceral Adipose Tissue Radiodensity Is Linked to Prognosis in Hepatocellular Carcinoma Patients Treated with Selective Internal Radiation Therapy
Maryam Ebadi, Carlos Moctezuma-Velazquez, Judith Meza-Junco, Vickie E. Baracos, Abha R. DunichandHoedl, Sunita Ghosh, Philippe Sarlieve, Richard J. Owen, Norman Kneteman, Aldo J. Montano-Loza
Cancers.2020; 12(2): 356. CrossRef
Review article: prognostic significance of body composition abnormalities in patients with cirrhosis
Maryam Ebadi, Rahima A. Bhanji, Puneeta Tandon, Vera Mazurak, Vickie E. Baracos, Aldo J. Montano‐Loza
Alimentary Pharmacology & Therapeutics.2020; 52(4): 600. CrossRef
Sarcopenia Severity Based on Computed Tomography Image Analysis in Patients with Cirrhosis
Maryam Ebadi, Rahima A. Bhanji, Abha R. Dunichand-Hoedl, Vera C. Mazurak, Vickie E. Baracos, Aldo J. Montano-Loza
Nutrients.2020; 12(11): 3463. CrossRef
Fat Accumulation, Liver Fibrosis, and Metabolic Abnormalities in Chinese Patients With Moderate/Severe Versus Mild Hepatic Steatosis
Wei Zhang, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Grace L. Su, Anna S. Lok
Hepatology Communications.2019; 3(12): 1585. CrossRef
Predicting Survival Using Pretreatment CT for Patients With Hepatocellular Carcinoma Treated With Transarterial Chemoembolization: Comparison of Models Using Radiomics
Jonghoon Kim, Seung Joon Choi, Seung-Hak Lee, Ho Yun Lee, Hyunjin Park
American Journal of Roentgenology.2018; 211(5): 1026. CrossRef
Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer
Joanne Marie O’Rourke, Vandana Mridhu Sagar, Tahir Shah, Shishir Shetty
World Journal of Gastroenterology.2018; 24(39): 4436. CrossRef
The Adverse Impact of Sarcopenia and Visceral Fat Deposition on the Course of Hepatocellular Carcinoma and the Role of Nutritional Interventions
Adam McCulloch, Hardip Malhi, Amritpal Dhaliwal, Sheldon Cooper, Tahir Shah
European Medical Journal.2018; : 126. CrossRef

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Clinicopathologic Characteristics and Prognosis of Tongue Squamous Cell Carcinoma in Patients with and without a History of Radiation for Nasopharyngeal Carcinoma: A Matched Case-Control Study: Peng Zhang, Li Zhang, Hui Liu, Lei Zhao, Yong Li, Jing-Xian Shen, Qing Liu, Meng-Zhong Liu, Mian Xi; Cancer Res Treat. 2017;49(3):695-705. Published online October 11, 2016; DOI: https://doi.org/10.4143/crt.2016.317

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Purpose
Previous studies reported an association between an increased risk of tongue cancer and radiation treatment for nasopharyngeal carcinoma (NPC). This study compared the clinicopathologic characteristics and outcomes of tongue squamous cell carcinoma (TSCC) in patients with and without a history of radiotherapy for NPC.
Materials and Methods
From 1965 to 2009, a total of 73 patients were diagnosed with TSCC with a history of radiotherapy for NPC. The patients were matched in a 1:3 ratio with patients with sporadic TSCC according to age, sex, and year of the TSCC diagnosis. The primary endpoint was the overall survival.
Results
The median interval from NPC to TSCC was 82 months. The NPC survivors were more likely to be diagnosed with a more advanced T classification, less likely to have lymph node involvement, and more likely to have the tumor located in the dorsum of the tongue than sporadic TSCC. Regarding the histologic characteristics, the NPC survivors were more likely to have a weak lymphocytic host response, low tumor budding, and low risk of a worse pattern of invasion. The sporadic TSCC patients had a better overall survival (hazard ratio, 0.690; p=0.033) than the NPC survivors. In competing risks analysis, the cumulative incidence functions for the competing event (documented non-tongue cancer death) were significantly higher in the NPC survivors (Gray’s test, p=0.001).
Conclusion
TSCC patients with a history of radiotherapy for NPC appear to have particular clinicopathologic features, a poorer survival, and are more likely to die from non-tongue cancer causes than those with sporadic TSCC.

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SPP1 and FN1 are significant gene biomarkers of tongue squamous cell carcinoma
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Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma
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Cancer Research and Treatment.2020; 52(1): 109. CrossRef
Second primary cancer after intensity-modulated radiotherapy for nasopharyngeal carcinoma: A territory-wide study by HKNPCSG
James C.H. Chow, Anthony H.P. Tam, Ka-Man Cheung, Victor H.F. Lee, Chi-Leung Chiang, Macy Tong, Edwin C.Y. Wong, Alice K.W. Cheung, Sunny P.C. Chan, Jessica W.Y. Lai, Roger K.C. Ngan, Wai-Tong Ng, Anne W.M. Lee, Kwok-Hung Au
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BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma
Miao Wang, Lu Zhao, Dongdong Tong, Linrui Yang, Hongjie Zhu, Qing Li, Fenghe Zhang
International Immunopharmacology.2019; 76: 105921. CrossRef
Surgical treatment of early tongue squamous cell carcinoma and patient survival
Lansheng Zhu, Yanling Wang, Rui Li, Aiqun Liu, Xiaoping Zhang, Chunran Zuo, Xiaoting Xu
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Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade
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Molecular Medicine Reports.2019;[Epub] CrossRef
Tumour budding in oral squamous cell carcinoma: a meta-analysis
Alhadi Almangush, Matti Pirinen, Ilkka Heikkinen, Antti A Mäkitie, Tuula Salo, Ilmo Leivo
British Journal of Cancer.2018; 118(4): 577. CrossRef
The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation
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Cancer Medicine.2018; 7(4): 1056. CrossRef
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy
Xiaoyan Fu, Shuwei Chen, Weichao Chen, Zhongyuan Yang, Ming Song, Hao Li, Huayong Zhang, Fan Yao, Xuan Su, Tianrun Liu, An-Kui Yang
Oral Oncology.2018; 84: 20. CrossRef

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