- Head and Neck cancer
-
Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect
-
Ozlem Ozkaya Akagunduz, Suzan Guven Yilmaz, Emin Tavlayan, Mine Esen Baris, Filiz Afrashi, Mustafa Esassolak
-
Cancer Res Treat. 2022;54(2):417-423. Published online June 24, 2021
-
DOI: https://doi.org/10.4143/crt.2021.575
-
-
Abstract
PDFPubReaderePub
- Purpose
This study aimed to evaluate the radiation-induced adverse effects on ocular structures in head and neck cancer patients and investigate the radiation dose-volume effects on the cornea, lacrimal gland, retina, optic nerve and chiasm.
Materials and Methods A total of 38 eyes of 19 patients were included in this prospective, cohort study. All patients underwent complete ophthalmological examination in addition to contrast sensitivity, visual field and visual evoked potentials (VEP) tests. Ophthalmological examinations and psychophysical tests were performed in 6th, 12th, 18th, 24th months and in the last visit. The relationship between the ophthalmologic findings, and the radiation doses below and above the cut-off values was evaluated.
Results Contrast sensitivity decrease and visual field deterioration were observed in 42% of the patients in the last visit (median 26 months) whereas a prolonged latency and decreased amplitude of P100 wave in VEP was observed in 58% and 33% of the eyes, respectively at 24th month. Totally 16 patients (84.2%) developed dry eye disease and eight of them received radiotherapy below tolerance doses and had mild to moderate dry eye findings. Radiation-induced retinopathy was observed in three of the eyes in eight patients who received radiation above tolerance dose.
Conclusion Head and neck cancers treated with radiotherapy, resulted in various ophthalmic complications. All patients who are treating with radiotherapy should be evaluated by an ophthalmologist in terms of anterior and posterior segment damage, even if the radiation dose is below the tolerance limit.
-
Citations
Citations to this article as recorded by
- Neurological complications of modern radiotherapy for head and neck cancer
James C.H. Chow, Jason C.S. Ho, Ka Man Cheung, David Johnson, Bonaventure Y.M. Ip, Jonathan J. Beitler, Primož Strojan, Antti A. Mäkitie, Avraham Eisbruch, Sweet Ping Ng, Sandra Nuyts, William M. Mendenhall, Silvia Babighian, Alfio Ferlito Radiotherapy and Oncology.2024; 194: 110200. CrossRef - Efficacy of Intravitreal Injections Anti-Vascular Endothelial Growth Factor Treatment for Radiation Retinopathy: A Systematic Review and Meta-analysis
Jiayuan Zhuang, Yang Yang, Yuexia Liao, Chenghao Li, Wen-an Wang, Xiangxia Luo, Heng Zhou American Journal of Ophthalmology.2024; 263: 141. CrossRef - Personalized treatment for patients with lacrimal sac squamous cell carcinoma
Jie Wang, Qi Zhang, Xiuqian Yi, Tianci Tang, Tian Wang, Xinmao Song Canadian Journal of Ophthalmology.2024;[Epub] CrossRef - Biomaterials-mediated radiation-induced diseases treatment and radiation protection
Jianping Man, Yanhua Shen, Yujie Song, Kai Yang, Pei Pei, Lin Hu Journal of Controlled Release.2024; 370: 318. CrossRef - Retinopatía por radiación vs. síndrome isquémico ocular: ¿cómo llegar al diagnóstico?
A. Aramburu-González, J. Zarrabeitia Carrandi, C.B. Robles Elejalde, A. Quilez Larragan Archivos de la Sociedad Española de Oftalmología.2024; 99(8): 352. CrossRef - Orbital cavernous venous malformation shrinkage during fractionated stereotactic radiotherapy contributing to the development of radiation retinopathy
Laura Hughes, Amy C Cohn, Neda Haghighi, Alan A McNab European Journal of Ophthalmology.2024; 34(5): NP53. CrossRef - Radiation retinopathy vs. ocular ischemic syndrome: how to reach the diagnosis?
A. Aramburu-González, J. Zarrabeitia Carrandi, C.B. Robles Elejalde, A. Quilez Larragan Archivos de la Sociedad Española de Oftalmología (English Edition).2024; 99(8): 352. CrossRef - Ocular surface changes in patients who have undergone head and neck radiation therapy
H Sujithra, Kannisha N Shah, R Anoop, Pushpaja K Ullattil, Gopal S Pillai, Greeshma C Ravindran, Jayesh Vazirani Indian Journal of Ophthalmology.2024;[Epub] CrossRef - New Frontiers in the Treatment of Patients with HER2+ Cancer and Brain Metastases: Is Radiotherapy Always Useful?
Giuseppa Scandurra, Valentina Lombardo, Giuseppe Scibilia, Daniela Sambataro, Vittorio Gebbia, Paolo Scollo, Basilio Pecorino, Maria Rosaria Valerio Cancers.2024; 16(13): 2466. CrossRef - Radiation-Induced Retinopathy and Optic Neuropathy after Radiation Therapy for Brain, Head, and Neck Tumors: A Systematic Review
Buket Kinaci-Tas, Tanja Alderliesten, Frank D. Verbraak, Coen R. N. Rasch Cancers.2023; 15(7): 1999. CrossRef - Radiation Retinopathy
Kaylie Chen, Andrew W. Browne Current Ophthalmology Reports.2023; 11(3): 49. CrossRef - Case Report: Optical coherence tomography angiography findings in radiation retinopathy
Wafa Ammari, Asma Zaghdoudi, Olfa Berriche, Riadh Messaoud F1000Research.2023; 11: 968. CrossRef - Case Report: Optical coherence tomography angiography findings in radiation retinopathy
Wafa Ammari, Asma Zaghdoudi, Olfa Berriche, Riadh Messaoud F1000Research.2023; 11: 968. CrossRef - Efficacy and Safety of Radiotherapy Combined with Pyrotinib in the Treatment of HER2-Positive Breast Cancer with Brain Metastases
Jie Huang, Wenqiang Zhu, Qiangzhi Duan, Chaomang Zhu, Xueling Shi, Hongyu Zhao, Peng Cai, Duojie Li Breast Cancer: Targets and Therapy.2023; Volume 15: 841. CrossRef - Comparable meibomian gland changes in patients with and without ocular graft-versus-host disease after hematopoietic stem cell transplantation
Wenxin Zhao, Jing Yang, Yinglin Liao, Hubert Yuenhei Lao, Quanbin Huang, Ling Jin, Jing Sun, Fen Huang, Lingyi Liang The Ocular Surface.2022; 25: 1. CrossRef - Case Report: Optical coherence tomography angiography findings in radiation retinopathy
Wafa Ammari, Asma Zaghdoudi, Olfa Berriche, Riadh Messaoud F1000Research.2022; 11: 968. CrossRef - Corneal Epithelial Stem Cells–Physiology, Pathophysiology and Therapeutic Options
Yue Ruan, Subao Jiang, Aytan Musayeva, Norbert Pfeiffer, Adrian Gericke Cells.2021; 10(9): 2302. CrossRef
-
7,113
View
-
382
Download
-
10
Web of Science
-
17
Crossref
|