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Sequential Responses of Adenocarcinoma of the Lung to Erlotinib after Gefitinib in Never Smoker Korean Woman
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Hoon-Kyo Kim, Myeong Im Ahn, Jinyoung Yoo, Chi Hong Kim, Hong-Jun Yang, Byoung Yong Shim
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Cancer Res Treat. 2007;39(1):37-39. Published online March 31, 2007
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DOI: https://doi.org/10.4143/crt.2007.39.1.37
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Abstract
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A patient with adenocarcinoma of the lung was treated sequentially using two kinds of EGFR tyrosine kinase inhibitors, gefitinib and erlotinib. The patient was a 73-year-old female who received gefitinib as a second line treatment, which resulted in a partial response with response duration of 6 months. After progression of the disease, the patient received erlotinib, which resulted in partial response again with response duration of 11.5 months. This observation suggests that treatment with erlotinib may be effective in patients who develop progressive disease after a primary treatment with gefitinib following an initial response.
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Citations
Citations to this article as recorded by 
- Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature
Navneet Singh World Journal of Clinical Oncology.2014; 5(5): 858. CrossRef - Successful Rechallenge with Gefitinib for an Initial Erlotinib-Responder with Advanced Lung Adenocarcinoma
Sung Chul Hong, Yun Su Sim, Jin Hwa Lee, Yon Ju Ryu, Jung Hyun Chang Tuberculosis and Respiratory Diseases.2011; 71(4): 286. CrossRef
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Lung Cancer Screening with Low-Dose Chest CT: Current Issues
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Myeong Im Ahn
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Cancer Res Treat. 2004;36(3):163-166. Published online June 30, 2004
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DOI: https://doi.org/10.4143/crt.2004.36.3.163
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Abstract
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Computed tomography offers many advantages over routine radiographs in screening for lung cancer, and it is clear that low-dose spiral CT screening can more frequently find considerably smaller lung cancers than previous detection tools. Recently, investigators have performed low-dose spiral CT scanning for screening of lung cancer, and have suggested that CT screening can depict lung cancers at smaller sizes and at earlier stages. With technological advances in spiral CT scanners, the detection rate of small noncalcified pulmonary nodules has markedly increased, with higher rates noted with thinner collimation of CT scanning. Unfortunately, the majority of these have proved to be benign, i.e. false positive results. If, even in part, CT features could be found to predict benign nodules without follow-up, the false-positive rate would be reduced, and consequently, the cost, emotional stress, radiation dose, morbidity and mortality associated with interventional procedures would also be reduced. There have been several studies trying to establish reliable CT features for benign lesions in small pulmonary nodules and to determine their outcome. Although these efforts have not completely resolved the issue of false positive results, it is expected that lessons will be learnt on how to manage these small nodules through experience with screening in the near future. Because pulmonary nodules on CT are much more common in Korea than in western countries, the management algorithm for screening CT-detected nodules should be modified according to different circumstances, with consensus among related physicians and radiologists. In addition, to enhance patient care and avoid misunderstanding of inherent limitation of CT screening by the screening subjects, physicians, hospital managers as well as radiologists should provide proper information regarding CT screening to the screenees.
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Citations
Citations to this article as recorded by 
- Overuse of CT and MRI in paediatric emergency departments
Orly Ohana, Shelly Soffer, Eyal Zimlichman, Eyal Klang The British Journal of Radiology.2018;[Epub] CrossRef - Radiological Report of Pilot Study for the Korean Lung Cancer Screening (K-LUCAS) Project: Feasibility of Implementing Lung Imaging Reporting and Data System
Ji Won Lee, Hyae Young Kim, Jin Mo Goo, Eun Young Kim, Soo Jung Lee, Tae Jung Kim, Yeol Kim, Juntae Lim Korean Journal of Radiology.2018; 19(4): 803. CrossRef - Screening for Early Detection of Cancers II
Hong Gwan Seo Journal of the Korean Medical Association.2006; 49(6): 515. CrossRef
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Lung Cancer Screening with Low-Dose Spiral CT
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Myeong Im Ahn
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Cancer Res Treat. 2002;34(1):13-16. Published online February 28, 2002
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DOI: https://doi.org/10.4143/crt.2002.34.1.13
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Abstract
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- No abstract available.
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