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Combination of Tumor Volume and Epstein-Barr Virus DNA Improved Prognostic Stratification of Stage II Nasopharyngeal Carcinoma in the Intensity Modulated Radiotherapy Era: A Large-Scale Cohort Study
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Qiu-Yan Chen, Shao-Yan Guo, Lin-Quan Tang, Tong-Yu Lu, Bo-Lin Chen, Qi-Yu Zhong, Meng-Sha Zou, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, Hai-Qiang Mai
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Cancer Res Treat. 2018;50(3):861-871. Published online September 13, 2017
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DOI: https://doi.org/10.4143/crt.2017.237
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 Abstract
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- Purpose
Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors.
Materials and Methods
By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above.
Results
Gross tumor volume of cervical lymph nodes (GTVnd, p < 0.001) and total tumor volume (GTVtotal, p < 0.001) were both closely related to pretreatment EBV DNA, while gross tumor volume of nasopharynx (GTVnx, p=0.047) was weakly related to EBV DNA. EBV DNA was significantly correlated with progress-free survival (PFS, p=0.005), locoregional-free survival (LRFS, p=0.039), and distant metastasis-free survival (DMFS, p=0.017), while GTVtotal, regardless of GTVnx and GTVnd, had a significant correlation with PFS and LRFS. The p-values of GTVtotal for PFS and LRFS were 0.008 and 0.001, respectively. According to GTVtotal and pretreatment EBV DNA level, patients were divided into a low-risk group (EBV DNA 0 copy/mL, GTVtotal < 30 cm3; EBV DNA 0 copy/mL, GTVtotal ≥ 30 cm3; or EBV DNA > 0 copy/mL, GTVtotal < 30 cm3) and a high-risk group (EBV DNA > 0 copy/mL, GTVtotal ≥ 30 cm3). When patients in the low-risk group were compared with those in the high-risk group, 3-year PFS (p=0.003), LRFS (p=0.010), and DMFS (p=0.031) rates were statistically significant.
Conclusion
Pretreatment plasma EBV DNA and tumor volume were both closely correlated with prognosis of stage II NPC patients in the IMRT era. Combination of EBV DNA and tumor volume can refine prognosis and indicate for clinical therapy.
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Citations
Citations to this article as recorded by  - Risk stratification of LA‐NPC during chemoradiotherapy based on clinical classification and TVRR
Qianlong Tang, Chaorong Mei, Bei Huang, Rui Huang, Le Kang, Ailin Chen, Na lei, Pengcheng Deng, Shouyan Ying, Peng Zhang, Yuan Qin
Cancer Medicine.2024;[Epub] CrossRef - A radiogenomic clinical decision support system to inform individualized treatment in advanced nasopharyngeal carcinoma
Xue-Liang Fang, Lian-Zhen Zhong, Wei Jiang, Cheng-Long Huang, Yuan Lei, Si-Qi Tang, Qing-Jie Li, Li-Zhi Liu, Li Tian, Ying-Qin Li, Yu-Pei Chen, Li Lin, Rui Guo, Wen-Fei Li, Jie Tian, Na Liu, Di Dong, Jun Ma, Ling-Long Tang
iScience.2024; 27(8): 110431. CrossRef - Epstein–Barr virus DNA change level combined with tumor volume reduction ratio after inductive chemotherapy as a better prognostic predictor in locally advanced nasopharyngeal carcinoma
Zhong‐zheng Xiang, Tao He, Yuan‐yuan Zeng, Fang Liu, Bian‐fei Shao, Tian Yang, Jia‐chun Ma, Xi‐ran Wang, Si‐ting Yu, Lei Liu
Cancer Medicine.2023; 12(2): 1102. CrossRef - A prognostic nomogram incorporating tumor size and lymph node size for patients with nasopharyngeal carcinoma
Qi Yi, Jiazuo Cai, Yunen Lin, Zimei Hu, Jie Lin, Zhong Huang, Wei Liu, Ronghui Zheng, YaWei Yuan, Chengcong Chen
American Journal of Otolaryngology.2023; 44(2): 103717. CrossRef - Tumor volume reduction after induction chemotherapy with gemcitabine plus cisplatin in nasopharyngeal carcinoma
Qian Chen, Liangfang Shen, Shan Li
European Archives of Oto-Rhino-Laryngology.2023; 280(5): 2497. CrossRef - High proportion of circulating CD8 + CD28- senescent T cells is an independent predictor of distant metastasis in nasopharyngeal carcinoma after radiotherapy
Xiaotian Xu, Fangze Wei, Lin Xiao, Runye Wu, Baojun Wei, Shengkai Huang, Junlin Yi, Wei Cui
Journal of Translational Medicine.2023;[Epub] CrossRef - MRI-based deep learning model predicts distant metastasis and chemotherapy benefit in stage II nasopharyngeal carcinoma
Yu-Jun Hu, Lin Zhang, You-Ping Xiao, Tian-Zhu Lu, Qiao-Juan Guo, Shao-Jun Lin, Lan Liu, Yun-Bin Chen, Zi-Lu Huang, Ya Liu, Yong Su, Li-Zhi Liu, Xiao-Chang Gong, Jian-Ji Pan, Jin-Gao Li, Yun-Fei Xia
iScience.2023; 26(6): 106932. CrossRef - The influence of tumor volume on the risk of distant metastases in head and neck squamous cell carcinomas
Julie Kjems, Katrin Elisabet Håkansson, Claus Andrup Kristensen, Jesper Grau Eriksen, Morten Horsholt Kristensen, Anne Ivalu Sander Holm, Jens Overgaard, Christian Rønn Hansen, Ruta Zukauskaite, Jørgen Johansen, Ivan Richter Vogelius, Jeppe Friborg
Radiotherapy and Oncology.2023; 186: 109771. CrossRef - The value of integrating tumor volume and plasma Epstein-Barr virus DNA load during sequential chemoradiotherapy for prognostic prediction and therapeutic guidance in high-risk locoregionally advanced nasopharyngeal carcinoma
Gaoyuan Wang, Zhe Dong, Chenglong Huang, Xiaojing Du, Lin Chen, Kunpeng Li, Rui Guo, Linglong Tang, Jun Ma
Oral Oncology.2023; 145: 106500. CrossRef - Clinical Significance of Baseline Epstein–Barr Virus DNA for Recurrent or Metastatic Primary Pulmonary Lymphoepithelioma-Like Carcinoma
Qihua Zou, Kongjia Luo, Liping Kang, Caiwen Huang, Jianliang Mai, Yongbin Lin, Ying Liang
Future Oncology.2023; 19(37): 2481. CrossRef - Predictive Value of ERCC1 mRNA Level from Receiver-Operator Characteristic and Pretreatment EBV-DNA Virus Load in Stage II Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy with Concurrent Cisplatin
Li Hua, Shaojun Chen, Mengzhuan Wei, Yongqi Shen, Jianxin Long, Zhan Lin, Yiliang Meng, Chengxian Guo, Haixin Huang, Xiaoning Tu, Min Yao
Cancer Biotherapy and Radiopharmaceuticals.2022; 37(1): 2. CrossRef - Development and prospective validation of a risk score model in guiding individualized concurrent chemoradiotherapy in stage II nasopharyngeal carcinoma in intensity‐modulated radiotherapy era
Shan‐Shan Yang, Ya‐Jun Pang, Zhi‐Qiang Wang, Bao‐Yu Zhang, Zhi‐Qiao Liu, En‐Ni Chen, Pu‐Yun OuYang, Fang‐Yun Xie
Cancer Medicine.2022; 11(4): 1109. CrossRef - Combined Association of Tumoral PD-L1 Expression and Pretreatment Presence of Epstein-Barr Virus DNA With Risk Stratification and Prognosis of Patients With Nasopharyngeal Carcinoma
Xiaoyu Li, Xingchen Peng, Sha Zhao, Hong Zhang, Yong Jiang, Fei Liu, Ping Ai
Frontiers in Oncology.2022;[Epub] CrossRef - Nomogram for distant metastasis-free survival in patients with locoregionally advanced nasopharyngeal carcinoma
Huiyun Yang, Rongjun Zhang, Ruyun Zhang, Bin Zhang, Yuan Xie, Guanjie Qin, Yunyan Mo, Xiaolan Ruan, Wei Jiang
Strahlentherapie und Onkologie.2022; 198(9): 828. CrossRef - Survival among subgroups of patients with stage II nasopharyngeal carcinoma
Shi-Ting Huang, Dan-Ke Su
Scientific Reports.2022;[Epub] CrossRef - Liquid Biopsy in Head and Neck Cancer: Current Evidence and Future Perspective on Squamous Cell, Salivary Gland, Paranasal Sinus and Nasopharyngeal Cancers
Santiago Cabezas-Camarero, Pedro Pérez-Segura
Cancers.2022; 14(12): 2858. CrossRef - Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
Laura Keller, Yassine Belloum, Harriet Wikman, Klaus Pantel
British Journal of Cancer.2021; 124(2): 345. CrossRef - Treatment Deescalation Strategies for Nasopharyngeal Cancer
Anna Lee, James C. H. Chow, Nancy Y. Lee
JAMA Oncology.2021; 7(3): 445. CrossRef - Clinical and survival analysis of nasopharyngeal carcinoma with consistently negative Epstein–Barr virus DNA
Zhi‐Gong Wei, Xiao‐Lin Hu, Yan He, Hui Guan, Jing‐Jing Wang, Ling He, Xiao‐Li Mu, Zhe‐Ran Liu, Rui‐Dan Li, Xing‐Chen Peng
Head & Neck.2021; 43(5): 1465. CrossRef - Accumulation of LOX-1+ PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein–barr virus and relate to tumor recurrence
Xing Li, Jin-Long Li, Nan Jiang, Jie Chen, Zi-Ming Liang, Zhen-Lin Zhao, Yan-Fang Xing
Aging.2021; 13(1): 437. CrossRef - A systematic review and recommendations on the use of plasma EBV DNA for nasopharyngeal carcinoma
Anne W.M. Lee, Victor H.F. Lee, Wai-Tong Ng, Primož Strojan, Nabil F. Saba, Alessandra Rinaldo, Stefan M. Willems, Juan P. Rodrigo, Arlene A. Forastiere, Alfio Ferlito
European Journal of Cancer.2021; 153: 109. CrossRef - Establishment of a Prognostic Nomogram for Patients With Locoregionally Advanced Nasopharyngeal Carcinoma Incorporating TNM Stage, Post-Induction Chemotherapy Tumor Volume and Epstein-Barr Virus DNA Load
Yu-Ting Jiang, Kai-Hua Chen, Jie Yang, Zhong-Guo Liang, Song Qu, Ling Li, Xiao-Dong Zhu
Frontiers in Oncology.2021;[Epub] CrossRef - Metastasis of nasopharyngeal carcinoma: What we know and do not know
Ling-Ling Guo, Hai-Yun Wang, Li-Sheng Zheng, Ming-Dian Wang, Yun Cao, Yang Li, Zhi-Jie Liu, Li-Xia Peng, Bi-Jun Huang, Jian-Yong Shao, Chao-Nan Qian
Visualized Cancer Medicine.2021; 2: 4. CrossRef - Prognostic Factors for Overall Survival in Nasopharyngeal Cancer and Implication for TNM Staging by UICC: A Systematic Review of the Literature
Chi Leung Chiang, Qiaojuan Guo, Wai Tong Ng, Shaojun Lin, Tiffany Sze Wai Ma, Zhiyuan Xu, Youping Xiao, Jishi Li, Tianzhu Lu, Horace Cheuk Wai Choi, Wenqi Chen, Eric Sze Chun Chau, Peter Ho Yin Luk, Shao Hui Huang, Brian O’Sullivan, Jianji Pan, Anne Wing
Frontiers in Oncology.2021;[Epub] CrossRef - External Validation of a Nomogram to Predict Survival and Benefit of Concurrent Chemoradiation for Stage II Nasopharyngeal Carcinoma
Pui-Lam Yip, Shing-Fung Lee, Cheuk-Wai Horace Choi, Po-Chung Sunny Chan, Ka-Wai Alice Cheung, Chung-Hang James Chow, Ka-Man Cheung, Wing-Yu Jessica Lai, Ho-Fun Victor Lee, Ka-On Lam, Chi-Leung Chiang, Chun-Yin Edwin Wong, Ming-Chun Darren Poon, Macy Tong,
Cancers.2021; 13(17): 4286. CrossRef - The efficacy of chemotherapy in survival of stage II nasopharyngeal carcinoma
Xin-Bin Pan, Ling Li, Song Qu, Long Chen, Shi-Xiong Liang, Xiao-Dong Zhu
Oral Oncology.2020; 101: 104520. CrossRef - Usefulness of Hybrid PET/MRI in Clinical Evaluation of Head and Neck Cancer Patients
Natalia Samolyk-Kogaczewska, Ewa Sierko, Dorota Dziemianczyk-Pakiela, Klaudia Beata Nowaszewska, Malgorzata Lukasik, Joanna Reszec
Cancers.2020; 12(2): 511. CrossRef - Prognostic efficacy of extensive invasion of primary tumor volume for T3-4 nasopharyngeal carcinoma receiving intensity-modulated radiotherapy
Fen Xue, Dan Ou, Xiaomin Ou, Xin Zhou, Chaosu Hu, Xiayun He
Oral Oncology.2020; 100: 104478. CrossRef - Establishment and validation of a nomogram for predicting the benefit of concurrent chemotherapy in stage II nasopharyngeal carcinoma: A study based on a phase III randomized clinical trial with 10-year follow-up
Xue-Song Sun, Xiao-Yun Li, Bei-Bei Xiao, Sai-Lan Liu, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai
Oral Oncology.2020; 100: 104490. CrossRef - Metastatic disease in head & neck oncology
Paolo Pisani, Mario Airoldi, Anastasia Allais, Paolo Aluffi Valletti, Mariapina Battista, Marco Benazzo, Roberto Briatore, Salvatore Cacciola, Salvatore Cocuzza, Andrea Colombo, Bice Conti, Alberto Costanzo, Laura della Vecchia, Nerina Denaro, Cesare Fant
Acta Otorhinolaryngologica Italica.2020; 40(SUPPL. 1): S1. CrossRef - BHRF1 Enhances EBV Mediated Nasopharyngeal Carcinoma Tumorigenesis through Modulating Mitophagy Associated with Mitochondrial Membrane Permeabilization Transition
Shujie Song, Zhiying Jiang, David Ethan Spezia-Lindner, Ting Liang, Chang Xu, Haifeng Wang, Ye Tian, Yidong Bai
Cells.2020; 9(5): 1158. CrossRef - Predictive Value of CD8 Expression and FoxP3 Methylation in Nasopharyngeal Carcinoma Patients Treated with Chemoradiotherapy in a Non-endemic Area
E. Muraro, E. Vaccher, C. Furlan, E. Fratta, G. Fanetti, D. A. Fae’, D. Martorelli, M. Cangemi, J. Polesel, F. Navarria, C. Gobitti, E. Comaro, C. Scaini, C. Pratesi, S. Zanussi, V. Lupato, G. Grando, V. Giacomarra, S. Sulfaro, L. Barzan, R. Dolcetti, A.
Pathology & Oncology Research.2020; 26(4): 2459. CrossRef - Prognostic Value of Programmed Cell Death-Ligand 1 Expression in Tumor-Infiltrating Lymphocytes and Viral Load in Peripheral Blood Mononuclear Cells for Epstein–Barr Virus–Positive Nasopharyngeal Carcinoma
Bin Hu, Ming Sun, Zijin Wang, Yanping Zheng, Weifeng Cai, Helen Hsiao-Hsing Shi, Yanzhen Zhuang, Qin Lin
Clinical Chemistry.2020; 66(9): 1219. CrossRef - Molecular Prognostic Value of Circulating Epstein–Barr Viral DNA in Nasopharyngeal Carcinoma: A Meta-Analysis of 27,235 Cases in the Endemic Area of Southeast Asia
Xulin Xie, Yupei Ren, Kun Wang, Bin Yi
Genetic Testing and Molecular Biomarkers.2019; 23(7): 448. CrossRef - Dynamic changes in plasma Epstein–Barr virus DNA load during treatment have prognostic value in nasopharyngeal carcinoma: a retrospective study
Sha‐Sha He, Yan Wang, Yong Bao, Xiu‐Yu Cai, Xing‐Li Yang, Dan‐Ming Chen, Yong Chen, Li‐Xia Lu
Cancer Medicine.2018; 7(4): 1110. CrossRef - Impact of paranasal sinus invasion on advanced nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy: the validity of advanced T stage of AJCC/UICC eighth edition staging system
Ying Wang, Jie Zhao, Yajie Zhao, Zhen Yang, Mingjun Lei, Zhanzhan Li, Rui Wei, Dengming Chen, Yuxiang He, Liangfang Shen
Cancer Medicine.2018; 7(7): 2826. CrossRef - Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004‐2013
S.‐J. Huang, Y.‐Y. Tang, H.‐M. Liu, G.‐X. Tan, X. Wang, H. Zhang, F. Yang, S. Yang
Clinical Otolaryngology.2018; 43(5): 1209. CrossRef - Relationship between pretreatment concentration of plasma Epstein‐Barr virus DNA and tumor burden in nasopharyngeal carcinoma: An updated interpretation
Liang Peng, Yi Yang, Rui Guo, Yan‐Ping Mao, Cheng Xu, Yu‐Pei Chen, Ying Sun, Jun Ma, Ling‐Long Tang
Cancer Medicine.2018; 7(12): 5988. CrossRef
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