Cancer Research and Treatment

Mee Sook Roh

6 Articles

Clinical Significance of Peroxisome Proliferator-Activated Receptor γ and TRAP220 in Patients with Operable Colorectal Cancer: Kyung A Kwon, Jeanho Yun, Sung Yong Oh, Bong-Gun Seo, Suee Lee, Ji-Hyun Lee, Sung-Hyun Kim, Hong Jo Choi, Mee Sook Roh, Hyo-Jin Kim; Cancer Res Treat. 2016;48(1):198-207. Published online June 23, 2015; DOI: https://doi.org/10.4143/crt.2015.024

Purpose
The peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that regulates expression of mediators of lipid metabolism and the inflammatory response. Thyroid hormone receptor-associated proteins 220 (TRAP220) is an essential component of the TRAP/Mediator complex. The objective of this study was to clarify whether PPARγ or TRAP220 are significant prognostic markers in resectable colorectal cancer (CRC).
Materials and Methods
A total of 399 patients who underwent curative resection for CRC were enrolled. We investigated the presence of PPARγ and TARP220 in CRC tissues and adjacent normal tissues by immunohistochemistry. Correlation between the expression of these factors and clinicopathologic features and survival was investigated.
Results
Median age of the patients was 63 years (range, 22 to 87 years), and median follow-up duration 61.1 months (range, 2 to 114 months). PPARγ and TRAP220 expression showed significant correlation with depth of invasion (p=0.013 and p=0.001, respectively). Expression of TRAP220 also showed association with lymph node metastasis and TNM stage (p=0.001). Compared with patients with TRAP220 negative tumors, patients with TRAP220 positive tumors had longer 5-year disease-free survival (DFS) tendency (p=0.051). Patients who were PPARγ positive combined with TRAP220 positive had a better 5-year DFS (64.8% vs. 79.3%, p=0.013). In multivariate analysis expression of both PPARγ and TRAP220 significantly affected DFS (hazard ratio, 0.620; 95% confidence interval, 0.379 to 0.997; p=0.048).
Conclusion
TRAP220 may be a valuable marker for nodal metastasis and TNM stage. Tumor co-expression of PPARγ and TRAP220 represents a biomarker for good prognosis in CRC patients.

Citations

Citations to this article as recorded by

Expression of Peroxisome Proliferator-Activated Receptor γ in Human Colorectal Carcinoma and Its Correlation with Clinicopathological Characteristics
Deepsikha Dharamsaktu, Jyotsna Naresh Bharti, Poonam Elhence, Meenakshi Rao, Jeewan Ram Vishnoi, Subash Chandra Soni, Neeti Rustagi
Indian Journal of Surgical Oncology.2024;[Epub] CrossRef
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers
Ruixi Xie, Ying Luo, Bowen Bao, Xinshu Wu, Jia Guo, Jin Wang, Xiujuan Qu, Xiaofang Che, Chunlei Zheng
Drug Development Research.2024;[Epub] CrossRef
A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer
Huihai Yang, Grace Gar Lee Yue, Ping Chung Leung, Chun Kwok Wong, Clara Bik San Lau
Pharmacological Research.2022; 175: 106031. CrossRef
UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control
Angèle Luby, Marie-Clotilde Alves-Guerra
International Journal of Molecular Sciences.2022; 23(23): 15077. CrossRef
Lycopene supplementation regulates the gene expression profile and fat metabolism of breeding hens
Hanchen Tian, Guangbin Liu, Yongqing Guo, Yaokun Li, Ming Deng, Dewu Liu, Baoli Sun
Journal of Animal Physiology and Animal Nutrition.2020; 104(3): 936. CrossRef
Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ
Jing Zhou, Zhanzhao Liu, Lingjing Zhang, Xiao Hu, Zhihua Wang, Hong Ni, Yue Wang, Junfang Qin
Cancer Research and Treatment.2020; 52(3): 830. CrossRef
Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage
Hyun-Ju Kim, Jeanho Yun
Acta Biochimica et Biophysica Sinica.2017; 49(6): 496. CrossRef
Expression and role of nuclear receptor coregulators in colorectal cancer
Mouna Triki, Marion Lapierre, Vincent Cavailles, Raja Mokdad-Gargouri
World Journal of Gastroenterology.2017; 23(25): 4480. CrossRef

11,318 View
64 Download
8 Web of Science
8 Crossref

Expressions of Matrix Metalloproteinase-7 and -9 and their Prognostic Significances in Rectal Cancer: Young Rak Cho, Hyuk-Chan Kwon, Sung-Hwan Suh, Jong Hoon Lee, Sung-Hyun Kim, Hong-Jo Choi, Hyung-Sik Lee, Mee Sook Roh, Tae-Ho Hwang, Jae-Seok Kim, Hyo-Jin Kim; Cancer Res Treat. 2005;37(6):354-359. Published online December 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.6.354

Abstract PDF PubReader ePub

Purpose

The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes. MMPs are known to be involved in tumor invasion, and several have been implicated in tumor prognosis. The aim of this study was to evaluate the prognostic significances of the expressions of MMP-7 and -9 in rectal cancer.

Materials and Methods

The tumor tissues of 87 patients with stage II or III rectal carcinoma that underwent potentially curative resection followed by postoperative adjuvant chemoradiation and 5-fluorouracil based chemotherapy, were investigated immunohistochemically using monoclonal antibodies against MMP-7 and MMP-9. Clinical information, including tumor grades, carcinoembryonic antigen (CEA) levels, and disease-free survival and overall survival were evaluated with respect to the expressions of MMP-7 and -9.

Results

Median follow-up duration was 53.2 months, and median patient age was 55±11 years (range 32~75). MMP-7 expression in tumor tissue was found to be significantly correlated with the presence of nodal metastasis (p=0.029), whilst MMP-9 expression correlated with depth of tumor invasion (p=0.019). No relationships were found between the expressions of MMP-7 or -9 and age, sex, tumor size, tumor grade, or CEA level. Univariate analysis showed that MMP-7 expression was associated with poor 5-year overall survival (12.8 months vs. 65.3 months, p=0.0405). Multivariate analysis confirmed that MMP-7 was independently associated with an adverse outcome (Relative risk: 1.415, p=0.027). However, MMP-9 expression was not found to be related to clinical outcome.

Conclusion

MMP-7 expression in tumor tissue is associated with lymph node metastasis and a poor 5-year overall survival in rectal cancer patients.

Citations

Citations to this article as recorded by

Effects of radiation on the metastatic process
Nora Sundahl, Fréderic Duprez, Piet Ost, Wilfried De Neve, Marc Mareel
Molecular Medicine.2018;[Epub] CrossRef
Prognostic significance of MMP-7 expression in colorectal cancer: A meta-analysis
Da-wei Sun, Ying-yi Zhang, Yue Qi, Xing-tong Zhou, Guo-yue Lv
Cancer Epidemiology.2015; 39(2): 135. CrossRef
Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis
Chun-Yu Li, Peng Yuan, Shu-Sen Lin, Cheng-Fei Song, Wei-Yu Guan, Lu Yuan, Rong-Bin Lai, Ying Gao, Yan Wang
Tumor Biology.2013; 34(2): 735. CrossRef

9,551 View
68 Download
3 Crossref

Impact of the New AJCC Staging System and Adjuvant Treatment in Rectal Cancer: Shin Ae Lee, Hyuk-Chan Kwon, Min Ah Park, Chang Kil Jung, Sung-Hyun Kim, Ki-Jae Park, Hong-Jo Choi, Hyung-Sik Lee, Mee Sook Roh, Jae-Seok Kim, Hyo-Jin Kim; Cancer Res Treat. 2004;36(2):121-127. Published online April 30, 2004; DOI: https://doi.org/10.4143/crt.2004.36.2.121

Abstract PDF PubReader ePub

Purpose

The combination of chemoradiation and fluorouracil based chemotherapy has been the standard adjuvant treatment for colorectal cancer patients. The aim of this study was to evaluate treatment outcome of patients classified by the new AJCC staging system and to compare treatment outcome of oral doxifluridine and the standard Mayo Clinic regimen after chemoradiation in advanced rectal cancer patients.

Materials and Methods

One hundred nine patients underwent curative surgical resection and chemoradiation followed by chemotherapy. 45 Gy pelvic irradiation was given to the entire pelvis and the boost radiation with 50.4 to 54 Gy, and simultaneously 5-fluorouracil (5-FU) 375 mg/m²/day was given on day 1~3 and 26~28. After the completion of chemoradiation, patients were given either 6 cycles of the Mayo Clinic regimen (5-FU 425 mg/m² plus leucovorin 20 mg/m² intravenous bolus infusion on day 1~5, every 4 weeks) or oral doxifluridine (600 mg/m²/day) for 1 year.

Results

The median follow-up duration was 30 months. Among 102 evaluable patients, 38 patients (37.3%) relapsed: the locoregional recurrence in 10 patients (9.8%) and systemic relapse in 28 patients (27.5%). The systemic relapse rate was 15.6% in the stage IIA, 25.0% in the stage IIIB , and 59.1% in the stage IIIC (p=0.048). The 5-year disease-free survival (DFS) rate was significantly higher in the IIA and IIIA patients than the IIIB and IIIC patients (72% and 100% vs 48.1% and 11.2%, respectively. p<0.001). The 5-year overall survival (OS) rate was also significantly different between in the IIA/IIIA patients and the IIIB/IIIC (67.3%/100% vs 48.4%/22.3%. p<0.001). However, the difference in DFS or OS between the oral doxifluridine group and the Mayo Clinic regimen group was not significant. Cox regression multivariate analyses showed that the new AJCC stage and tumor differentiation were significant independent prognostic factors in DFS and OS.

Conclusion

These results support that the new AJCC staging system is superior to Dukes' staging system in the prognostic stratification. Regarding DFS and OS, oral doxifluridine is comparable to the standard Mayo Clinic regimen in rectal cancer patients when combined with postoperative chemoradiation. Stage IIIC patients should be selected for aggressive therapy as they have a dismal prognosis.

Citations

Citations to this article as recorded by

Emerging Roles of Circulating Tumor DNA for Increased Precision and Personalization in Radiation Oncology
Noah Earland, Kevin Chen, Nicholas P. Semenkovich, Pradeep S. Chauhan, Jose P. Zevallos, Aadel A. Chaudhuri
Seminars in Radiation Oncology.2023; 33(3): 262. CrossRef
Development and validation of a competitive risk model in patients with rectal cancer: based on SEER database
Ruobing Hu, Xiuling Li, Xiaomin Zhou, Songze Ding
European Journal of Medical Research.2023;[Epub] CrossRef
miR-663b promotes colorectal cancer progression by activating Ras/Raf signaling through downregulation of TNK1
Sen Hong, Zhenkun Yan, Helei Wang, Lei Ding, Yumei Song, Miaomiao Bi
Human Cell.2020; 33(1): 104. CrossRef
Current controversy, confusion, and imprecision in the use and interpretation of rectal MRI
Marc J. Gollub, Chandana Lall, Neeraj Lalwani, Michael H. Rosenthal
Abdominal Radiology.2019; 44(11): 3549. CrossRef
Prognostic significance of CD168 overexpression in colorectal cancer
Ke Wang, Tao Zhang
Oncology Letters.2016; 12(4): 2555. CrossRef
Safety of Early Chemotherapy after a Laparoscopic Colorectal Cancer Resection: A Case-Control Study
Seung Ho Shin, Sun-Il Lee, Dong-Jin Choi, Si-Uk Woo, Jin Kim, Byung-Wook Min, Hong-Young Moon, Seon Hahn Kim
Journal of the Korean Society of Coloproctology.2009; 25(6): 429. CrossRef

9,723 View
46 Download
6 Crossref

Relationship between PTEN and Vascular Endothelial Growth Factor Expression in Non-Small Cell Lung Cancer: Mee Sook Roh, Jae Ik Lee, Doo Kyung Yang, Soo Keol Lee, Hyuk Chan Kwon, Mi Kyoung Park, Ki Baek Hwang, Jin A Jung; Cancer Res Treat. 2003;35(5):445-450. Published online October 31, 2003; DOI: https://doi.org/10.4143/crt.2003.35.5.445

Abstract PDF

PURPOSE
This study was performed to determine the relationship between PTEN and vascular endothelial growth factor (VEGF) expression and to assess their roles in the tumor-induced angiogenesis and tumor progression in non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissues, from 96 patients diagnosed with NSCLC, were evaluated for VEGF and PTEN expression using immunohistochemical methods. The results of the expression pattern of VEGF alone, or in combination with PTEN expression, were compared with clinicopathological parameters. RESULTS: VEGF expression was seen in 54 (56.3%) of the 96 NSCLCs evaluated, and was significantly correlated with histological type, and seen more frequently in adenocarcinomas compared to the other histological types (p<0.05). There were no significant associations between VEGF expression and tumor size, lymph node metastasis and stage. The microvessel density (MVD) determined by CD34 staining were significantly higher in tumors with VEGF expression (62.9+/-21.8) than those without (55.1+/-15.1). Loss of PTEN expression was seen in 33 (34.4%) of the 96 NSCLCs evaluated. VEGF expression was more frequently detected in the tumors with loss of PTEN expression (69.7%) than in those with PTEN expression (49.2%). When the combined VEGF/ PTEN phenotypes were divide into two groups; group I (VEGF-/PTEN+) and group II (VEGF-/ PTEN-, VEGF+/PTEN+, VEGF+/PTEN-), a significant correlation was also seen between the groups and the histologic types. There was a trend for the tumors in group II to show more frequent lymph node metastasis (50.0%) than those in group I (31.5%), although there was no statistical significance. The MVDs were significantly higher in group II (63.1+/-20.7) than in group I (53.4+/-17.2). CONCLUSION: These findings demonstrate an inverse correlation between the expressions of PTEN and VEGF. It is possible that PTEN may repress VEGF expression, and modulate VEGF-mediated angiogenesis, which suggests further analysis of the complex phenomenon of neo-angiogenesis in NSCLC is essential.

Citations

Citations to this article as recorded by

Molecular and biological characterization of hepatitis B virus subgenotype F1b clusters: Unraveling its role in hepatocarcinogenesis
María Mercedes Elizalde, Laura Mojsiejczuk, Micaela Speroni, Belén Bouzas, Luciana Tadey, Lilia Mammana, Rodolfo Héctor Campos, Diego Martín Flichman
Frontiers in Microbiology.2022;[Epub] CrossRef
KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: Implication for combinatorial approach
Young‐Kwang Yoon, Hwang‐Phill Kim, Sae‐Won Han, Do Youn Oh, Seock‐Ah Im, Yung‐Jue Bang, Tae‐You Kim
Molecular Carcinogenesis.2010; 49(4): 353. CrossRef
Phosphatase and Tensin Homolog Reconstruction and Vascular Endothelial Growth Factor Knockdown Synergistically Inhibit the Growth of Glioblastoma
Hongbo Chen, Xiaomeng Shen, Caiping Guo, Huijun Zhu, Lanzhen Zhou, Yongqiang Zhu, Huixia Wang, Yi Zheng, Laiqiang Huang
Cancer Biotherapy and Radiopharmaceuticals.2010; 25(6): 713. CrossRef

3,519 View
56 Download
3 Crossref

Gene Expression Profiling of Non-Small Cell Lung Cancer: Mee Sook Roh, Hyuk Chan Kwon, Jin Sook Jeong, Dae Cheol Kim, Choon Hee Son, Soo Keol Lee, Phil Jo Choi, Jae Ik Lee, Ki Nam Lee, Hyo Jin Kim, Jin Han Yoon, Tae Ho Hwang; Cancer Res Treat. 2003;35(2):154-160. Published online April 30, 2003; DOI: https://doi.org/10.4143/crt.2003.35.2.154

Abstract PDF

PURPOSE
cDNA microarray provided a powerful alternative, with an unprecedented view scope, in monitoring gene expression levels, and led to the discovery of regulatory pathways involved in complicated biological processes. This study was performed to gain better understanding of the molecular mechanisms underlying the carcinogenesis and progression of lung cancer. MATERIALS AND METHODS: Using a cDNA microarray, representing 4, 600 cDNA clusters, we studied the expression profiles in 10 non-small cell lung cancer (NSCLC) samples and the adjacent noncancerous lung tissues form the same patients. The alterations in the levels of gene expression were confirmed by reverse-transcription PCR in 10 randomly selected genes.
RESULTS
Genes that were differently expressed in the cancerous and noncancerous tissues were identified. One hundred and nine genes (of which 68 were known) and 69 cDNAs (of which 32 were known) were up- and down-regulated in>70% of the NSCLC samples, respectively. In the cancerous tissues, the genes related to the cell cycle, metabolism, cell structure and signal transduction, were mostly up-regulated. Furthermore, we identified a few putative tumor suppressor genes that had previously been proposed by other workers. CONCLUSIONS: These results provide, not only a new molecular basis for understanding the biological properties of NSCLC, but also useful resources for the future development of diagnostic markers and therapeutic targets for NSCLC.

Citations

Citations to this article as recorded by

Expression of double‐stranded RNA‐activated protein kinase in small‐size peripheral adenocarcinoma of the lung
Mee Sook Roh, Ju Young Kwak, Su Jin Kim, Hyun Wook Lee, Hyuk Chan Kwon, Tae Ho Hwang, Phil Jo Choi, Young Seoub Hong
Pathology International.2005; 55(11): 688. CrossRef

4,087 View
34 Download
1 Crossref

Tumor Angiogenesis as a Predictor of Malignancy Potential and Prognosis in Gastric Carcinoma: Chang Wuk Kang, Hyung Ho Kim, Young Hoon Kim, Se Heon Cho, Sang Soon Kim, Mee Sook Roh, Suk Hee Hong, Choong Rak Kim; J Korean Cancer Assoc. 2000;32(1):19-25.

Abstract PDF: PURPOSE
In order to evaluate the clinical relevance of angiogenesis in patients with gastric cancer, we investigated the microvessel count in gastric cancer tissues and compared the results with several clinicopathologic factors and prognosis.
MATERIALS AND METHODS
A total of 256 patients with gastric cancer who underwent curative surgery were included in this study. Microvessel count was determined by im-munohistochemical staining using monoclonal antibody against factor VIII-related antigen.
RESULTS
The statistical significance between the microvessel count and clinicopathologic factors (age, sex, tumor invasion, lymph node involvement, histologic type) was analized. The tumor stage and histologic type were correlated with microvessel count. And also there was statistical significance with survival rate and recurrence-free survival rate between high (microvessel count> or =42) and low angiogeneic group (microvessel count< 42). The Cox's proportional hazard model showed that stage, histologic type, angiogeneic score were one of the significant and independent prognostic variables.
CONCLUSION
The tumor angiogenesis of gastric carcinoma may be independent prognostic factor for predicting recurrence and survival.

2,957 View
16 Download

Author index