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Efficacy of Combined Gemcitabine/Cisplatin Chemotherapy for Locally Advanced or Metastatic Urothelial Cancer
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Kwan-Sik Bae, Kyu Il Ahn, Seung Hyun Jeon, Jung-Sik Huh, Sung-Goo Chang
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Cancer Res Treat. 2006;38(2):78-83. Published online April 30, 2006
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DOI: https://doi.org/10.4143/crt.2006.38.2.78
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Abstract
PDFPubReaderePub
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We wanted to determine and report on the outcome of combined gemcitabine/cisplatin chemotherapy for patients suffering with locally advanced or metastatic urothelial cancer. Materials and MethodsBetween July 1999 and December 2004, 43 selected patients were enrolled in this study. Group 1 (the adjuvant chemotherapy group) had undergone radical surgery with removal of evident tumor from the following primary sites: bladder (n=8), renal pelvis (n=7) and ureter (n=3). Group 2 (the salvage chemotherapy group) had undergone palliative surgery with a remnant tumor at the following primary sites; bladder (n=23) and renal pelvis (n=2). All the patients were given gemcitabine/ciplatin and they evaluated for the therapeutic effect and toxicity. The patients were initially treated with gemcitabine 1000 mg/m2 intravenously for 30 minutes on days 1, 8 and 15 of a 28-day cycle, and cisplatin 70 mg/m2 was administered intravenously on day 1 using prehydration measures. ResultsGroup 1: The median follow-up period was 16.5 months. The mean age was 63 years (males: 15 cases, females: 3 cases), and eleven patients (61%) remained alive. The estimated median relapse-free survival period and 2-year survival rate were 24 months and 63%, respectively. Group 2: the median follow-up period was 20 months, the mean patient age was 63.8 years (males: 22 cases, females: 3 cases), and nine patients (36%) remained alive. The overall response and 2-year survival rates were 36% and 43%, respectively. Toxicities: Grade 3 toxicities developed in 14 cycles during the total 232 cycles. Grade 4 toxicity did not occur. ConclusionsThe results of this study confirm that adjuvant and salvage chemotherapy with using gemcitabine and cisplatin is tolerable and safe.
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Citations
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- Chemotherapy with gemcitabine, cisplatin, and docetaxel in the treatment for patients with muscle-invasive bladder cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)
Ioannis Boukovinas, Nikolaos Androulakis, Nikolaos Kentepozidis, Aris Polyzos, Pavlos Papakotoulas, Nikolaos Ziras, Athanasios Kotsakis, Nikolaos Vardakis, Athanasios Karampeazis, Vassilis Markos, Athanasios Kostakopoulos, Constantine A. Constantinides, G Cancer Chemotherapy and Pharmacology.2012; 69(2): 351. CrossRef
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