Cancer Research and Treatment

Keun Won Ryu

6 Articles

Gastrointestinal Cancer

Development and Validation of a Symptom-Focused Quality of Life Questionnaire (KOQUSS-40) for Gastric Cancer Patients after Gastrectomy: Bang Wool Eom, Joongyub Lee, In Seob Lee, Young-Gil Son, Keun Won Ryu, Sung Geun Kim, Hyoung-Il Kim, Young-Woo Kim, Seong-Ho Kong, Oh Kyoung Kwon, Ji-Ho Park, Ji Yeong An, Chang Hyun Kim, Byoung-Jo Suh, Hong Man Yoon, Myoung Won Son, Ji Yeon Park, Jong-Min Park, Sang-Ho Jeong, Moon-Won Yoo, Geum Jong Song, Han-Kwang Yang, Yun-Suhk Suh, Ki Bum Park, Sang-Hoon Ahn, Dong Woo Shin, Ye Seob Jee, Hye-Seong Ahn, Sol Lee, Jae Seok Min, Haejin In, Ahyoung Kim, Hoon Hur, Hyuk-Joon Lee, on behalf of KOrean QUality of life in Stomach cancer patients Study group (KOQUSS); Cancer Res Treat. 2021;53(3):763-772. Published online December 29, 2020; DOI: https://doi.org/10.4143/crt.2020.1270

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Purpose
Patients who have undergone gastrectomy have unique symptoms that are not appropriately assessed using currently available tools. This study developed and validated a symptom-focused quality of life (QoL) questionnaire for patients who have received gastrectomy for gastric cancer. Materials and Methods Based on a literature review, patient interviews, and expert consultation by the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS), the initial item pool was developed. Two large-scale developmental studies were then sequentially conducted for exploratory factor analyses for content validity and item reduction. The final item pool was validated in a separate cohort of patients and assessed for internal consistency, test-retest reliability, construct validity, and clinical validity.
Results
The initial questionnaire consisted of 46-items in 12 domains. Data from 465 patients at 11 institutions, followed by 499 patients at 13 institutions, were used to conduct item reduction and exploratory factor analyses. The final questionnaire (KOQUSS-40) comprised 40 items within 11 domains. Validation of KOQUSS-40 was conducted on 413 patients from 12 hospitals. KOQUSS-40 was found to have good model fit. The mean summary score of the KOQUSS-40 was correlated with the EORTC QLQ-C30 and STO22 (correlation coefficients, 0.821 and 0.778, respectively). The KOQUSS-40 score was also correlated with clinical factors, and had acceptable internal consistency (> 0.7). Test-retest reliability was greater than 0.8. Conclusion The KOQUSS-40 can be used to assess QoL of gastric cancer patients after gastrectomy and allows for a robust comparison of surgical techniques in clinical trials.

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Global status of research on gastrointestinal cancer patients’ quality of life: A bibliometric and visual analysis from 2003 to 2023
Xiaoqin Wang, Caihua Wang, Wenjin Han, Jiaru Sun, Zhaozhao Hui, Shuangyan Lei, Huili Wu, Xiaohong Liu
Heliyon.2024; 10(1): e23377. CrossRef
Development and Feasibility Assessment of Mobile Application-Based Digital Therapeutics for Postoperative Supportive Care in Gastric Cancer Patients Following Gastrectomy
Ji-Hyeon Park, Hyuk-Joon Lee, JeeSun Kim, Yo-Seok Cho, Sunjoo Lee, Seongmin Park, Hwinyeong Choe, Eunhwa Song, Youngran Kim, Seong-Ho Kong, Do Joong Park, Byung-Ho Nam, Han-Kwang Yang
Journal of Gastric Cancer.2024; 24(4): 420. CrossRef
Effect of Four Main Gastrectomy Procedures for Proximal Gastric Cancer on Patient Quality of Life: A Nationwide Multi-Institutional Study
Koji Nakada, Akitoshi Kimura, Kazuhiro Yoshida, Nobue Futawatari, Kazunari Misawa, Kuniaki Aridome, Yoshiyuki Fujiwara, Kazuaki Tanabe, Hirofumi Kawakubo, Atsushi Oshio, Yasuhiro Kodera
Journal of Gastric Cancer.2023; 23(2): 275. CrossRef
Quality of life after gastric cancer surgery
Jae Kyun Park, Hyuk-Joon Lee
Foregut Surgery.2023; 3(2): 27. CrossRef
Long-term Functional and Patient-reported Outcomes Between Intra-corporeal Delta-shaped Gastroduodenostomy and Gastrojejunostomy After Laparoscopic Distal Gastrectomy
Sin Hye Park, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Mira Han, Bang Wool Eom
Journal of Gastric Cancer.2023; 23(4): 561. CrossRef
Potential Applicability of Local Resection With Prophylactic Left Gastric Artery Basin Dissection for Early-Stage Gastric Cancer in the Upper Third of the Stomach
Yoshimasa Akashi, Koichi Ogawa, Katsuji Hisakura, Tsuyoshi Enomoto, Yusuke Ohara, Yohei Owada, Shinji Hashimoto, Kazuhiro Takahashi, Osamu Shimomura, Manami Doi, Yoshihiro Miyazaki, Kinji Furuya, Shoko Moue, Tatsuya Oda
Journal of Gastric Cancer.2022; 22(3): 184. CrossRef
Systematic review of health-related quality of life (HRQoL) issues associated with gastric cancer: capturing cross-cultural differences
Alison Rowsell, Samantha C. Sodergren, Vassilios Vassiliou, Anne-Sophie Darlington, Marianne G. Guren, Bilal Alkhaffaf, Chantelle Moorbey, Kristopher Dennis, Mitsumi Terada
Gastric Cancer.2022; 25(4): 665. CrossRef
Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors
Rui Xu, Qiong Gu, Shuomeng Xiao, Ping Zhao, Zhi Ding
Frontiers in Oncology.2022;[Epub] CrossRef
Prospective multicentre randomised clinical trial comparing survival rates, quality of life and nutritional status between advanced gastric cancer patients with different follow-up intensities: study protocol for the STOFOLUP trial
Bang Wool Eom, Dong-Hoe Koo, Ji Yeong An, Han Hong Lee, Hyoung-Il Kim, Hoon Hur, Moon-Won Yoo, Min-Hee Ryu, Hyuk-Joon Lee, Su Mi Kim, Ji-Ho Park, Jae Seok Min, Kyung Won Seo, Sang-Ho Jeong, Oh Jeong, Oh Kyoung Kwon, Seung Wan Ryu, Chang Hak Yoo, Jae Moon
BMJ Open.2021; 11(12): e056187. CrossRef

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Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population: Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim; Cancer Res Treat. 2019;51(2):748-757. Published online September 5, 2018; DOI: https://doi.org/10.4143/crt.2018.162

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Purpose
Half of the world’s gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have revealed susceptibility genes associated with gastric cancer, no GWASs have been conducted in the Korean population, which has the highest incidence of gastric cancer.
Materials and Methods
We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and 3,693 healthy controls.
Results
We showed that the rs2976394 in the prostate stem cell antigen (PSCA) gene is a gastriccancer-susceptibility gene in a Korean population, with genome-wide significance and an odds ratio (OR) of 0.70 (95% confidence interval [CI], 0.64 to 0.77). A strong linkage disequilibrium with rs2294008 was also found, indicating an association with susceptibility. Individuals with the CC genotype of the PSCA gene showed an approximately 2-fold lower risk of gastric cancer compared to those with the TT genotype (OR, 0.47; 95% CI, 0.39 to 0.57). The effect of the PSCA gene on gastric cancer was more prominent in the female population and for diffuse type gastric cancer.
Conclusion
Our result confirmed that the PSCA gene may be the most important susceptibility gene for gastric cancer risk in a Korean population.

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Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population
Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
Cancer Research and Treatment.2024; 56(1): 191. CrossRef
HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer
Ansley Gnanapragasam, Eftyhios Kirbizakis, Anna Li, Kyle H. White, Katelyn L. Mortenson, Juliana Cavalcante de Moura, Wajih Jawhar, Yifei Yan, Reilly Falter, Colleen Russett, Betty Giannias, Sophie Camilleri-Broët, Nicholas Bertos, Jonathan Cools-Lartigue
Cancer Research.2024; 84(14): 2377. CrossRef
High Polygenic Risk Scores Positively Associated with Gastric Cancer Risk Interact with Coffee and Polyphenol Intake and Smoking Status in Korean Adults
Meiling Liu, Sang-Shin Song, Sunmin Park
Nutrients.2024; 16(19): 3263. CrossRef
Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2023; 130(5): 887. CrossRef
Rare variants confer shared susceptibility to gastrointestinal tract cancer risk
Ji Zheng, Xin Wang, Jingrao Li, Yuanna Wu, Jiang Chang, Junyi Xin, Meilin Wang, Tianpei Wang, Qingyi Wei, Mengyun Wang, Ruoxin Zhang
Frontiers in Oncology.2023;[Epub] CrossRef
The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Clinical Nutrition.2022; 76(7): 1031. CrossRef
Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development
Sangjun Lee, Han-Kwang Yang, Hyuk-Joon Lee, Do Joong Park, Seong-Ho Kong, Sue K. Park
Frontiers in Genetics.2022;[Epub] CrossRef
Incidence of Hereditary Gastric Cancer May Be Much Higher than Reported
Paula Baraúna de Assumpção, Paulo Pimentel de Assumpção, Fabiano Cordeiro Moreira, Ândrea Ribeiro-dos-Santos, Amanda F. Vidal, Leandro Magalhães, André Salim Khayat, André Maurício Ribeiro-dos-Santos, Giovanna C. Cavalcante, Adenilson Leão Pereira, Inácio
Cancers.2022; 14(24): 6125. CrossRef
Enhancing the Trajectories of Cancer Health Disparities Research: Improving Clinical Applications of Diversity, Equity, Inclusion, and Accessibility
Rachel Martini, Endale Gebregzabher, Lisa Newman, Melissa B. Davis
Cancer Discovery.2022; 12(6): 1428. CrossRef
Identification of Novel Susceptible Genes of Gastric Cancer Based on Integrated Omics Data
Huang Yaoxing, Yu Danchun, Sun Xiaojuan, Jiang Shuman, Yan Qingqing, Jia Lin
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Nutrients.2021; 13(8): 2600. CrossRef
Integration of GWAS and eQTL Analysis to Identify Risk Loci and Susceptibility Genes for Gastric Cancer
Jing Ni, Bin Deng, Meng Zhu, Yuzhuo Wang, Caiwang Yan, Tianpei Wang, Yaqian Liu, Gang Li, Yanbing Ding, Guangfu Jin
Frontiers in Genetics.2020;[Epub] CrossRef
Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population
Risa L. Iwasaki, Koji Ishiya, Hideaki Kanzawa-Kiriyama, Yosuke Kawai, Jun Gojobori, Yoko Satta
Genes.2020; 11(7): 775. CrossRef
TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study
Jeeeun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
Scientific Reports.2020;[Epub] CrossRef
Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population
Fei Bai, Ke Xiao
Bioscience Reports.2020;[Epub] CrossRef
Incidence of Stomach and Esophageal Cancers in Mongolia: Data from 2009 to 2018
Tsegmed Sambuu, Nasanjargal Tumurbat, Bayar Davaa, Bolor-Erdene Tudev
Euroasian Journal of Hepato-Gastroenterology.2020; 10(1): 16. CrossRef

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Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study: Sarah Yang, Yoon Park, Jeonghee Lee, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Joohon Sung, Jeongseon Kim; Cancer Res Treat. 2017;49(4):1044-1056. Published online January 19, 2017; DOI: https://doi.org/10.4143/crt.2016.515

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Purpose
The current study investigated whether the combined effects of soy intake and genetic polymorphisms of interleukin (IL) genes modify gastric cancer risk.
Materials and Methods
A total of 377 cases and 754 controls of Korean origin were included in the analysis. Soy consumption was assessed using a semi-quantitative food frequency questionnaire. Seven variants of IL10 (rs1800871), IL2 (rs2069763 and rs2069762), IL13 (rs6596090 and rs20541), and IL4R(rs7205663 and rs1805010) were genetically analyzed. To analyze the combined effect of soy intake and genetic polymorphisms, a low-intake group and high-intake group of each type of soy were categorized based on the intake level of the control group. Interactions between soy products and these genetic variants were analyzed by a likelihood ratio test, in which a multiplicative interaction term was added to the logistic regression model.
Results
A higher intake of nonfermented soy products was associated with a reduced cancer risk (odds ratio [OR], 0.62; 95% confidence interval [CI], 0.43 to 0.90), and the reduced risk was only apparent in males (OR, 0.44; 95% CI, 0.27 to 0.71). None of the IL genetic polymorphisms examined were independently associated with gastric cancer risk. Individuals with a minor allele of IL2 rs2069762 and a higher intake of nonfermented soy food had a decreased risk of gastric cancer (OR, 0.46; 95% CI, 0.31 to 0.68) compared to those with a lower intake (p_interaction=0.039).
Conclusion
Based on the genetic characteristics of the studied individuals, the interaction between IL2 rs2069762 and nonfermented soy intake may modify the risk of gastric cancer.

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Polyphenol intake and gastric cancer: A case-control study in the Brazilian Amazon region
Marcela de Araújo Fagundes, Renata Alves Carnauba, Gisele Aparecida Fernandes, Paulo Pimentel de Assumpção, Maria Paula Curado
Cancer Epidemiology.2024; 88: 102518. CrossRef
Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review
SK Aziz Ikbal, Surendra Kumar Yadav, Roopanshi Mehrotra, Tasneem Fatima, Anjusha Sharda, Srashti Gupta
The Journal of Contemporary Dental Practice.2024; 24(11): 902. CrossRef
The pertinence of gastric cancer and interleukin 10–819 single nucleotide polymorphisms: a meta-analysis and systematic review
Qianqian Mao, Yanwen Liu, Xi Chen, Cheng Jiang Liu
BMC Gastroenterology.2024;[Epub] CrossRef
Soy Product Consumption and the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies
Chenting Wang, Keqing Ding, Xuanzhen Xie, Jinyue Zhou, Pengju Liu, Shuang Wang, Ting Fang, Guozhang Xu, Chunlan Tang, Hang Hong
Nutrients.2024; 16(7): 986. CrossRef
Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2023; 130(5): 887. CrossRef
Association between soy products, fruits, vegetables, and dairy products and gastric cancer risk in Helicobacter pylori-infected subjects: a case-control study in Korea
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Nutrition Research and Practice.2023; 17(1): 122. CrossRef
Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies
Ji Hyun Kim, Shinyoung Jun, Jeongseon Kim
Epidemiology and Health.2023; : e2023102. CrossRef
The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Clinical Nutrition.2022; 76(7): 1031. CrossRef
Dietary Polyphenol Intake and Gastric Cancer: A Systematic Review and Meta-Analysis
Marcela de Araújo Fagundes, Alex Richard Costa Silva, Gisele Aparecida Fernandes, Maria Paula Curado
Cancers.2022; 14(23): 5878. CrossRef
Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
BMC Gastroenterology.2022;[Epub] CrossRef
Dietary patterns and gastric cancer risk in a Korean population: a case–control study
Ji Hyun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Nutrition.2021; 60(1): 389. CrossRef
Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
International Journal of Molecular Sciences.2021; 22(2): 727. CrossRef
The association between soy‐based food and soy isoflavone intake and the risk of gastric cancer: a systematic review and meta‐analysis
Yameng Wang, Jiaping Guo, Fei Yu, Yongmei Tian, Yongjun Wu, Lingling Cui, Li‐e Liu
Journal of the Science of Food and Agriculture.2021; 101(13): 5314. CrossRef
The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Nutrients.2021; 13(8): 2600. CrossRef
Identification of Dietary Pattern Networks Associated with Gastric Cancer Using Gaussian Graphical Models: A Case-Control Study
Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Cancers.2020; 12(4): 1044. CrossRef
Genome‐wide profiling of normal gastric mucosa identifies Helicobacter pylori‐ and cancer‐associated DNA methylome changes
Hae Dong Woo, Nora Fernandez‐Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young‐Il Kim, Jeongseon Kim, Zdenko Herceg
International Journal of Cancer.2018; 143(3): 597. CrossRef
The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies
Jie You, Yafei Sun, Yacong Bo, Yiwei Zhu, Dandan Duan, Han Cui, Quanjun Lu
BMC Public Health.2018;[Epub] CrossRef

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Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer: Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Myeong-Cherl Kook, Keun Won Ryu, Young-Woo Kim, Il Ju Choi; Cancer Res Treat. 2016;48(3):1020-1029. Published online November 17, 2015; DOI: https://doi.org/10.4143/crt.2015.264

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Purpose
Negative Helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (GC) patients who underwent surgery. The aim of this study was to examine the effect of H. pylori eradication on long-term outcomes after distal gastrectomy for GC.
Materials and Methods
We analyzed the survival of 169 distal GC patients enrolled in a prospective randomized trial evaluating histologic changes of gastric mucosa after H. pylori eradication in the remnant stomach. The outcomes measured were overall survival (OS) and GC recurrence rates.
Results
The median follow-up duration was 9.4 years. In the modified intention-to-treat analysis including patients who underwent H. pylori treatment (n=87) or placebo (n=82), 5-year OS rates were 98.9% in the treatment group and 91.5% in the placebo group, and KaplanMeier analysis showed no significant difference in OS (p=0.957) between groups. In multivariate analysis, no difference in overall mortality was observed between groups (adjusted hazard ratio [aHR] for H. pylori treatment, 0.75; p=0.495) or H. pylori-eradicated status (aHR for positive H. pylori status, 1.16; p=0.715), while old age, male sex, and advanced stage ≥ IIIa were independent risk factors. Six patients in the treatment group (6.9%) and seven patients in the placebo group (8.5%) had GC recurrences, and GC recurrence rates were not different according to H. pylori treatment (5-year GC recurrence rates, 4.6% in the treatment group vs. 8.5% in the placebo group; p=0.652).
Conclusion
H. pylori eradication for GC patients who underwent distal gastrectomy did not compromise long-term survival after surgery.

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Anti–Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy
Zhoukai Zhao, Ruopeng Zhang, Guoming Chen, Man Nie, Feiyang Zhang, Xiaojiang Chen, Jun Lin, Zewei Chen, Feizhi Lin, Chengzhi Wei, Ziqi Zheng, Shenghang Ruan, Bowen Huang, Yingbo Chen, Runcong Nie
JAMA Network Open.2024; 7(3): e243812. CrossRef
Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study
Kubilay Issever, Ersin Kuloglu, Demet Sengul, Ali Muhtaroglu, Ahmet Cumhur Dulger
Cureus.2023;[Epub] CrossRef
The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study
Senichiro Yanagawa, Nobuaki Fujikuni, Kazuaki Tanabe, Masahiro Nakahara, Toshio Noriyuki
Cancer Reports.2023;[Epub] CrossRef
Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis
Zhifang Jia, Min Zheng, Jing Jiang, Donghui Cao, Yanhua Wu, Yuzheng Zhang, Yingli Fu, Xueyuan Cao
BMC Cancer.2022;[Epub] CrossRef
Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Journal of Gastroenterology.2022; 57(7): 464. CrossRef
Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toHelicobacter pyloriEradication in Korea
Young-Il Kim, Il Ju Choi
Journal of Gastric Cancer.2022; 22(3): 169. CrossRef
Helicobacter Pylori and Gastric Cancer Progression
Marina A. Senchukova
Current Microbiology.2022;[Epub] CrossRef
Identifying Factors Affecting Cancer-related Death in Patients with Adenocarcinoma Gastric Cancer; An Analysis in the Presence of Competing Risks
Malihe Safari, Hossein Mahjub, Habib Esmaeili, Mohamad Abasi, Ghodratollah Roshanaei
International Journal of Cancer Management.2021;[Epub] CrossRef
T stage and venous invasion are crucial prognostic factors for long-term survival of patients with remnant gastric cancer: a cohort study
Kentaro Matsuo, Sang-Woong Lee, Ryo Tanaka, Yoshiro Imai, Kotaro Honda, Kohei Taniguchi, Hideki Tomiyama, Kazuhisa Uchiyama
World Journal of Surgical Oncology.2021;[Epub] CrossRef
Tracking the Virulent Helicobacter pylori Strains Instead of Its Pan-Screening to Prevent Gastric Cancer
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BioNanoScience.2020; 10(1): 315. CrossRef
Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: A meta-analysis
Bo Li, Xiaoqian Lan, Li Wang, Jiani Zhao, Jingli Ding, Hao Ding, Jun Lei, Yiping Wei, Wenxiong Zhang
Microbial Pathogenesis.2020; 142: 104075. CrossRef
Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow-up for up to 15 years
Yonghoon Choi, Nayoung Kim, Chang Yong Yun, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sang-Hoon Ahn, Do Joong Park, Hye Seung Lee, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim
Gastric Cancer.2020; 23(6): 1051. CrossRef
Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
Gastrointestinal Endoscopy.2020; 92(3): 613. CrossRef
Helicobacter pylori Eradication in Patients Undergoing Gastrectomy: Diagnosis and Therapy
Youn I Choi, Jun-Won Chung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(3): 204. CrossRef
Helicobacter pylori Eradication in Adult Patients with Acute Idiopathic Thrombocytopenic Purpura (ITP)
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Journal of Advances in Medical and Biomedical Research.2019; 27(124): 1. CrossRef
Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer
Il Ju Choi, Myeong-Cherl Kook, Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Boram Park, Byung-Ho Nam
New England Journal of Medicine.2018; 378(12): 1085. CrossRef
Helicobacter pyloriEradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials
Bum Jun Kim, Hyeong Su Kim, Hyun Joo Jang, Jung Han Kim
Gastroenterology Research and Practice.2018; 2018: 1. CrossRef
Do We Need to Retest of Helicobacter pylori Infection after Gastric Cancer Surgery?
Sang Kil Lee
Gut and Liver.2017; 11(2): 169. CrossRef

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Long-Term Low-Dose Aspirin Use Reduces Gastric Cancer Incidence: A Nationwide Cohort Study: Young-Il Kim, So Young Kim, Ji Hyun Kim, Jun Ho Lee, Young-Woo Kim, Keun Won Ryu, Jong-Hyock Park, Il Ju Choi; Cancer Res Treat. 2016;48(2):798-805. Published online July 14, 2015; DOI: https://doi.org/10.4143/crt.2015.117

Abstract PDF PubReader ePub

Purpose
The aim of this study was to investigate whether aspirin use can reduce the incidence of gastric cancer in patients with hypertension or type 2 diabetes. Materials and Methods A total of 200,000 patients with hypertension or type 2 diabetes were randomly selected from the Korean National Health Insurance claim database. Of these, 3,907 patients who used 100 mg of aspirin regularly (regular aspirin users) and 7,808 patients who did not use aspirin regularly (aspirin non-users) were selected at a frequency of 1:2, matched by age, sex, comorbid illnesses (type 2 diabetes and hypertension), and observation periods. The incidence of gastric cancer in this cohort was then assessed during the observation period of 2004 to 2010.
Results
In the matched cohort, the incidence rates of gastric cancer were 0.8% (31/3,907) for regular aspirin users and 1.1% (86/7,808) for aspirin non-users, but the cumulative incidence rates were not significantly different between groups (p=0.116, log-rank test). However, in multivariate analysis, regular aspirin users had a reduced risk of gastric cancer (adjusted hazard ratio [aHR], 0.71; 95% confidential interval [CI], 0.47 to 1.08; p=0.107). Duration of aspirin use showed significant association with reduction of gastric cancer risk (aHR for each year of aspirin use, 0.85; 95% CI, 0.73 to 0.99; p=0.044), particularly in patients who used aspirin for more than 3 years (aHR, 0.40; 95% CI, 0.16 to 0.98; p=0.045). Conclusion Long-term low-dose aspirin use was associated with reduced gastric cancer risk in patients with hypertension or type 2 diabetes.

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Exposure to Commonly Used Drugs and the Risk of Gastric Cancer: An Umbrella Review of Meta-Analyses
Xiao Bai, Si-Qi Ding, Xue-Ping Zhang, Ming-Hao Han, Dong-Qiu Dai
Cancers.2023; 15(2): 372. CrossRef
In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells
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Characteristics of Synchronous Cancers in Gastric Cancer Patients: Ja Seong Bae, Jun Ho Lee, Keun Won Ryu, Young Woo Kim, Jae Moon Bae; Cancer Res Treat. 2006;38(1):25-29. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.25

Abstract PDF PubReader ePub

Purpose

The primary objective of the current study was to investigate the characteristics of synchronous cancers in gastric cancer patients.

Materials and Methods

We analyzed the 2,237 patients who were diagnosed between December 2000 and December 2003 with gastric cancer and synchronous cancers of organs other than the stomach.

Results

73 (3.3%) of a total of 2,237 gastric cancer patients had synchronous primary cancers. Among these 73 patients, 71 had one synchronous cancer, and two patients had double synchronous cancers. Colorectal cancer (26 patients, 34.7%) was the most frequently encountered synchronous cancer, followed by cancer of the lung (16 patients, 21.3%), esophagus (13 patients, 17.2%), and liver (8 patients, 10.7%). Synchronous cancers were detected with increased frequency in the elderly, in the patients with multiple gastric cancers, in the patients with differentiated gastric cancer, and in the patients with early gastric cancer, as determined on univariate analysis, but the differentiation of gastric cancers was the only risk factor for synchronous cancers on the multivariate analysis.

Conclusions

The differentiation of gastric cancer cells may be a risk factor for synchronous cancers in gastric cancer patients. Careful surveillance by the physician for synchronous cancer is warranted for the patients suffering from gastric cancer.

Citations

Citations to this article as recorded by

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