- Gastrointestinal cancer
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An Innovative Prognostic Model Based on Four Genes in Asian Patient with Gastric Cancer
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Jiahui Chen, Anqiang Wang, Jun Ji, Kai Zhou, Zhaode Bu, Guoqing Lyu, Jiafu Ji
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Cancer Res Treat. 2021;53(1):148-161. Published online August 31, 2020
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DOI: https://doi.org/10.4143/crt.2020.424
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 Abstract
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- Purpose
Gastric cancer (GC) has substantial biological differences between Asian and non-Asian populations, which makes it difficult to have a unified predictive measure for all people. We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients.
Materials and Methods
We investigated the differential gene expression between GC and normal tissues of GSE66229. Univariate, multivariate and Lasso Cox regression analyses were conducted to establish a four-gene-related prognostic model based on the risk score. The risk score was based on a linear combination of the expression levels of individual genes multiplied by their multivariate Cox regression coefficients. Validation of the prognostic model was conducted using The Cancer Genome Atlas (TCGA) database. A nomogram containing clinical characteristics and the prognostic model was established to predict the prognosis of Asian GC patients.
Results
Four genes (RBPMS2, RGN, PLEKHS1, and CT83) were selected to establish the prognostic model, and it was validated in the TCGA Asian cohort. Receiver operating characteristic analysis confirmed the sensitivity and specificity of the prognostic model. Based on the prognostic model, a nomogram containing clinical characteristics and the prognostic model was established, and Harrell’s concordance index of the nomogram for evaluating the overall survival significantly higher than the model only focuses on the pathologic stage (0.74 vs. 0.64, p < 0.001).
Conclusion
The four-gene-related prognostic model and the nomogram based on it are reliable tools for predicting the overall survival of Asian GC patients.
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Citations
Citations to this article as recorded by  - Nivolumab plus anlotinib hydrochloride in advanced gastric adenocarcinoma and esophageal squamous cell carcinoma: the phase II OASIS trial
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Nature Communications.2024;[Epub] CrossRef - An integrated analysis of prognostic mRNA signature in early- and progressive-stage gastric adenocarcinoma
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International Journal of Genomics.2022; 2022: 1. CrossRef - KK-LC-1 may be an effective prognostic biomarker for gastric cancer
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BMC Cancer.2021;[Epub] CrossRef - Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer
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Scientific Reports.2021;[Epub] CrossRef - Integrative analysis-based identification and validation of a prognostic immune cell infiltration-based model for patients with advanced gastric cancer
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International Immunopharmacology.2021; 101: 108258. CrossRef
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