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An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma
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Liang Chen, Hongyuan Fu, Tongyu Lu, Jianye Cai, Wei Liu, Jia Yao, Jinliang Liang, Hui Zhao, Jiebin Zhang, Jun Zheng, Yingcai Zhang, Yang Yang
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Cancer Res Treat. 2020;52(2):469-480. Published online October 7, 2019
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DOI: https://doi.org/10.4143/crt.2019.423
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 Abstract
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- Purpose
Microtubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy.
Materials and Methods
From August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry.
Results
The 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively.
Conclusion
The nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients.
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Citations
Citations to this article as recorded by  - Lymph node metastasis of intrahepatic cholangiocarcinoma: the present and prospect of detection and dissection
Ruoyu Zhang, Yunfei Tan, Mei Liu, Liming Wang
European Journal of Gastroenterology & Hepatology.2024; 36(12): 1359. CrossRef - Active Autophagy Is Associated with Favorable Outcome in Patients with Surgically Resected Cholangiocarcinoma
Katrin Bankov, Falko Schulze, Steffen Gretser, Henning Reis, Nada Abedin, Fabian Finkelmeier, Jörg Trojan, Stefan Zeuzem, Andreas A. Schnitzbauer, Dirk Walter, Peter J. Wild, Maximilian N. Kinzler
Cancers.2023; 15(17): 4322. CrossRef - The role and implication of autophagy in cholangiocarcinoma
Hayat Khizar, Yufei Hu, Yanhua Wu, Jianfeng Yang
Cell Death Discovery.2023;[Epub] CrossRef - Immunogenomics of cholangiocarcinoma
Virag Gehl, Colm J. O’Rourke, Jesper B. Andersen
Hepatology.2023;[Epub] CrossRef - Multiparametric MRI‐Based Radiomic Signature for Preoperative Evaluation of Overall Survival in Intrahepatic Cholangiocarcinoma After Partial Hepatectomy
Yang Yang, Xianlun Zou, Wei Zhou, Guanjie Yuan, Daoyu Hu, Dong Kuang, Yaqi Shen, Qingguo Xie, Qingpeng Zhang, Xuemei Hu, Zhen Li
Journal of Magnetic Resonance Imaging.2022; 56(3): 739. CrossRef - A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma
Jing Liang, Hui Zhou, Xiang-Qi Huang, Yan-Fei Liu, Lei Zhang, Dan He, Yongmei Cui, Jinrui Guo, Kunpeng Hu, Chong Wu
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef - Therapeutic Potential of Autophagy Modulation in Cholangiocarcinoma
Hector Perez-Montoyo
Cells.2020; 9(3): 614. CrossRef
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