-
Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program
-
Jaeho Lee, Juntae Lim, Yeol Kim, Hyae Young Kim, Jin Mo Goo, Choon-Taek Lee, Seung Hun Jang, Won-Chul Lee, Chan Wha Lee, Jin Young An, Ki Dong Ko, Min Ki Lee, Kui Son Choi, Boyoung Park, Duk Hyoung Lee
-
Cancer Res Treat. 2019;51(4):1285-1294. Published online February 19, 2019
-
DOI: https://doi.org/10.4143/crt.2018.464
-
-
 Abstract
 PDF PubReader ePub
- Purpose
To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement National Cancer Screening Program in Korea.
Materials and Methods
Multidisciplinary expert committee was comprised to develop a standardized protocol for Korean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS.
Results
In pilot test, 256 were participated. The average age of participants was 63.2 years and only three participants (1.2%) were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and nine (3.5%) were grade 4. One participant was diagnosed as lung cancer.
Conclusion
The protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.
-
Citations
Citations to this article as recorded by  - Gender Disparities and Lung Cancer Screening Outcomes Among Individuals Who Have Never Smoked
Yeon Wook Kim, Dong-Hyun Joo, So Yeon Kim, Young Sik Park, Sowon Jang, Jong Hyuk Lee, Gerard A. Silvestri, Marjolein A. Heuvelmans, Jihang Kim, Hyeontaek Hwang, Choon-Taek Lee
JAMA Network Open.2025; 8(1): e2454057. CrossRef - Advancing the Implementation of Risk Model-Based Lung Cancer Screening
Yeon Wook Kim, Choon-Taek Lee
Journal of Thoracic Oncology.2025; 20(4): 419. CrossRef - Artificial Intelligence for Low-Dose CT Lung Cancer Screening: Comparison of Utilization Scenarios
Meesun Lee, Eui Jin Hwang, Jong Hyuk Lee, Ju Gang Nam, Woo Hyeon Lim, Hyungin Park, Chang Min Park, Hyewon Choi, Jongsoo Park, Jin Mo Goo
American Journal of Roentgenology.2025;[Epub] CrossRef - Impact of pulmonary tuberculosis on lung cancer screening: a narrative review
Jeong Uk Lim
Ewha Medical Journal.2025; 48(2): e23. CrossRef - Diagnostic Performance of the Modified Lung CT Screening Reporting and Data System in a TB-Endemic Country
Hyungjin Kim, Eunseo Jo, Jinseob Kim, Nayoung Lee, Jin Mo Goo, Yeol Kim
CHEST.2025;[Epub] CrossRef - Factors influencing the intention for lung cancer screening in high-risk populations for lung cancer
Mi-Kyoung Cho, Yoon Hee Cho
Asia-Pacific Journal of Oncology Nursing.2024; 11(1): 100332. CrossRef - Strategies to Improve Smoking Cessation for Participants in Lung Cancer Screening Program: Analysis of Factors Associated with Smoking Cessation in Korean Lung Cancer Screening Project (K-LUCAS)
Yeol Kim, Jaeho Lee, Eunju Lee, Juntae Lim, Yonghyun Kim, Choon-Taek Lee, Seung Hun Jang, Yu-Jin Paek, Won-Chul Lee, Chan Wha Lee, Hyae Young Kim, Jin Mo Goo, Kui Son Choi, Boyoung Park, Duk Hyoung Lee, Hong Gwan Seo
Cancer Research and Treatment.2024; 56(1): 92. CrossRef - Real‐world treatment patterns and clinical outcomes in patients with stage III NSCLC in Korea: The KINDLE study
Jiyun Lee, Hee Kyung Ahn, Sang‐We Kim, Ji‐Youn Han, Sung Sook Lee, Hyung Soon Park, Hyun Woo Lee, Joo‐Hang Kim, Eunhan Cho, Reto Huggenberger, Byoung Chul Cho
Cancer Medicine.2024;[Epub] CrossRef - Survival of lung cancer patients according to screening eligibility using Korean Lung Cancer Registry 2014–2016
Sangwon Lee, Eun Hye Park, Bo Yun Jang, Ye Ji Kang, Kyu-Won Jung, Hyo Soung Cha, Kui Son Choi
Scientific Reports.2024;[Epub] CrossRef - Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study
So Yeon Kim, Gerard A. Silvestri, Yeon Wook Kim, Roger Y. Kim, Sang-Won Um, Yunjoo Im, Jung Hye Hwang, Seung Ho Choi, Jung Seop Eom, Kang Mo Gu, Yong-Soo Kwon, Shin Yup Lee, Hyun Woo Lee, Dong Won Park, Yeonjeong Heo, Seung Hun Jang, Kwang Yong Choi, Yeol
Journal of Thoracic Oncology.2024;[Epub] CrossRef - Lung Cancer Screening: Implementation Challenges and Health Equity Considerations For the Western Pacific Region
Claire Nightingale, Claire Bavor, Emily Stone, Nicole M. Rankin
JCO Global Oncology.2023;[Epub] CrossRef - Lung Imaging Reporting and Data System (Lung-RADS) in Radiology: Strengths, Weaknesses and Improvement
Gong Yong Jin
Journal of the Korean Society of Radiology.2023; 84(1): 34. CrossRef - Trends in Survival Rates of Non–Small Cell Lung Cancer With Use of Molecular Testing and Targeted Therapy in Korea, 2010-2020
Sang Ah Chi, Hyeyeon Yu, Yoon-La Choi, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Dae-Ho Choi, Kyunga Kim, Hyun Ae Jung, Keunchil Park
JAMA Network Open.2023; 6(3): e232002. CrossRef - Interstitial Lung Abnormalities at CT in the Korean National Lung Cancer Screening Program: Prevalence and Deep Learning–based Texture Analysis
Kum Ju Chae, Soyeoun Lim, Joon Beom Seo, Hye Jeon Hwang, Hyemi Choi, David Lynch, Gong Yong Jin
Radiology.2023;[Epub] CrossRef - Developing a pan-European technical standard for a comprehensive high-quality lung cancer computed tomography screening programme: an ERS technical standard
David R. Baldwin, Emma L. O'Dowd, Ilona Tietzova, Anna Kerpel-Fronius, Marjolein A. Heuvelmans, Annemiek Snoeckx, Haseem Ashraf, Hans-Ulrich Kauczor, Blin Nagavci, Matthijs Oudkerk, Paul Martin Putora, Witold Ryzman, Giulia Veronesi, Andrea Borondy-Kitts,
European Respiratory Journal.2023; 61(6): 2300128. CrossRef - Association of immunotoxicological indices with lung cancer biomarkers in poultry, grape, and rose farming workers
Anju Maharjan, Ravi Gautam, Manju Acharya, JiHun Jo, DaEun Lee, Pramod Bahadur K C, Young-A Lee, Jung-Taek Kwon, HyoCher Kim, KyungRan Kim, ChangYul Kim, HyoungAh Kim, Yong Heo
Toxicological Research.2023; 39(4): 739. CrossRef - Performance of Lung-RADS in different target populations: a systematic review and meta-analysis
Yifei Mao, Jiali Cai, Marjolein A. Heuvelmans, Rozemarijn Vliegenthart, Harry J. M. Groen, Matthijs Oudkerk, Marleen Vonder, Monique D. Dorrius, Geertruida H. de Bock
European Radiology.2023; 34(3): 1877. CrossRef - Perspectives and limitations of Lung-RADS in different target populations: the power of systematic review and meta-analysis
Simone Vicini
European Radiology.2023; 34(3): 1875. CrossRef - The effect of the introduction of the national lung cancer screening program on short-term mortality in Korea
Woorim Kim, Sang Chul Lee, Woo-Ri Lee, Sungyoun Chun
Lung Cancer.2023; 186: 107412. CrossRef - Study on the Application Value of Lung-RADS in the Differential Diagnosis of Benign and Malignant Lung Nodules
·马木提 依力夏提
Advances in Clinical Medicine.2023; 13(12): 20190. CrossRef - Lung Cancer Screening with Low-Dose Chest Computed Tomography
Yeon Wook Kim
The Korean Journal of Medicine.2022; 97(1): 42. CrossRef - Cost Utility Analysis of a Pilot Study for the Korean Lung Cancer Screening Project
Juyoung Kim, Bogeum Cho, Seon-Ha Kim, Chang-Min Choi, Yeol Kim, Min-Woo Jo
Cancer Research and Treatment.2022; 54(3): 728. CrossRef - Potential Overdiagnosis with CT Lung Cancer Screening in Taiwanese Female: Status in South Korea
Jin Mo Goo, Kyu-Won Jung, Hyae Young Kim, Yeol Kim
Korean Journal of Radiology.2022; 23(6): 571. CrossRef - Lung Cancer Patients’ Characteristics and Comorbidities Using the Korean National Hospital Discharge In-depth Injury Survey Data
Kyunghee Lee, Sunghong Kang, Jieun Hwang
Journal of Epidemiology and Global Health.2022; 12(3): 258. CrossRef - Reduced Cancer Screening Due to Lockdowns of the COVID-19 Pandemic: Reviewing Impacts and Ways to Counteract the Impacts
Tuan Luu
Frontiers in Oncology.2022;[Epub] CrossRef - Determination of the optimum definition of growth evaluation for indeterminate pulmonary nodules detected in lung cancer screening
Jong Hyuk Lee, Eui Jin Hwang, Woo Hyeon Lim, Jin Mo Goo, Paul Cronin
PLOS ONE.2022; 17(9): e0274583. CrossRef - Implementation of the cloud-based computerized interpretation system in a nationwide lung cancer screening with low-dose CT: comparison with the conventional reading system
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Soon Ho Yoon, Yeol Kim
European Radiology.2021; 31(1): 475. CrossRef - Lung cancer LDCT screening and mortality reduction — evidence, pitfalls and future perspectives
Matthijs Oudkerk, ShiYuan Liu, Marjolein A. Heuvelmans, Joan E. Walter, John K. Field
Nature Reviews Clinical Oncology.2021; 18(3): 135. CrossRef - Variability in interpretation of low-dose chest CT using computerized assessment in a nationwide lung cancer screening program: comparison of prospective reading at individual institutions and retrospective central reading
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Soon Ho Yoon, Gong Yong Jin, Jaeyoun Yi, Yeol Kim
European Radiology.2021; 31(5): 2845. CrossRef - External validation and comparison of the Brock model and Lung-RADS for the baseline lung cancer CT screening using data from the Korean Lung Cancer Screening Project
Hyungjin Kim, Hyae Young Kim, Jin Mo Goo, Yeol Kim
European Radiology.2021; 31(6): 4004. CrossRef - Lung Screening Benefits and Challenges: A Review of The Data and Outline for Implementation
Jacob Sands, Martin C. Tammemägi, Sebastien Couraud, David R. Baldwin, Andrea Borondy-Kitts, David Yankelevitz, Jennifer Lewis, Fred Grannis, Hans-Ulrich Kauczor, Oyunbileg von Stackelberg, Lecia Sequist, Ugo Pastorino, Brady McKee
Journal of Thoracic Oncology.2021; 16(1): 37. CrossRef - Optimum diameter threshold for lung nodules at baseline lung cancer screening with low-dose chest CT: exploration of results from the Korean Lung Cancer Screening Project
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
European Radiology.2021; 31(9): 7202. CrossRef - Effectiveness of radiologist training in improving reader agreement for Lung-RADS 4X categorization
Hyungjin Kim, Jin Mo Goo, Tae Jung Kim, Hyae Young Kim, Guanmin Gu, Bomi Gil, Wooil Kim, Seon Young Park, Junghoan Park, Juil Park, Harkhoon Park, Wonkyu Song, Kyung Eun Shin, Jiseon Oh, Sung Hyun Yoon, Sanghyup Lee, Youkyung Lee, Woo Hyeon Lim, Won Gi Je
European Radiology.2021; 31(11): 8147. CrossRef - Contemporary issues in the implementation of lung cancer screening
Stephen Lam, Martin Tammemagi
European Respiratory Review.2021; 30(161): 200288. CrossRef - Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis
John K. Field, Daniel Vulkan, Michael P.A. Davies, David R. Baldwin, Kate E. Brain, Anand Devaraj, Tim Eisen, John Gosney, Beverley A. Green, John A. Holemans, Terry Kavanagh, Keith M. Kerr, Martin Ledson, Kate J. Lifford, Fiona E. McRonald, Arjun Nair, R
The Lancet Regional Health - Europe.2021; 10: 100179. CrossRef - Assisted versus Manual Interpretation of Low-Dose CT Scans for Lung Cancer Screening: Impact on Lung-RADS Agreement
Colin Jacobs, Anton Schreuder, Sarah J. van Riel, Ernst Th. Scholten, Rianne Wittenberg, Mathilde M. Winkler Wille, Bartjan de Hoop, Ralf Sprengers, Onno M. Mets, Bram Geurts, Mathias Prokop, Cornelia Schaefer-Prokop, Bram van Ginneken
Radiology: Imaging Cancer.2021; 3(5): e200160. CrossRef - Coronary artery calcium severity grading on non-ECG-gated low-dose chest computed tomography: a multiple-observer study in a nationwide lung cancer screening registry
Young Joo Suh, Ji Won Lee, So Youn Shin, Jin Mo Goo, Yeol Kim, Hwan Seok Yong
European Radiology.2020; 30(7): 3684. CrossRef - Korean National Lung Cancer Screening
Seung Hun Jang
The Korean Journal of Medicine.2020; 95(2): 95. CrossRef - Lung Cancer CT Screening and Lung-RADS in a Tuberculosis-endemic Country: The Korean Lung Cancer Screening Project (K-LUCAS)
Hyungjin Kim, Hyae Young Kim, Jin Mo Goo, Yeol Kim
Radiology.2020; 296(1): 181. CrossRef - Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society
Hiroto Hatabu, Gary M Hunninghake, Luca Richeldi, Kevin K Brown, Athol U Wells, Martine Remy-Jardin, Johny Verschakelen, Andrew G Nicholson, Mary B Beasley, David C Christiani, Raúl San José Estépar, Joon Beom Seo, Takeshi Johkoh, Nicola Sverzellati, Chri
The Lancet Respiratory Medicine.2020; 8(7): 726. CrossRef - Milestones towards lung cancer screening implementation
M. Silva, G. Milanese, H.-U. Kauczor, M.-P. Revel, N. Sverzellati
Clinical Radiology.2020; 75(12): 881. CrossRef - Evidence of National Lung Cancer Screening Program in Korea
Yeol Kim
Korean Journal of Health Promotion.2019; 19(4): 161. CrossRef
-
11,694
View
-
375
Download
-
39
Web of Science
-
42
Crossref
-
Diagnostic Value of Circulating Extracellular miR-134, miR-185, and miR-22 Levels in Lung Adenocarcinoma-Associated Malignant Pleural Effusion
-
Yoon Mi Shin, Jieun Yun, Ok-Jun Lee, Hye-Suk Han, Sung-Nam Lim, Jin Young An, Ki Hyeong Lee, Ki Man Lee, Kang Hyeon Choe
-
Cancer Res Treat. 2014;46(2):178-185. Published online April 15, 2014
-
DOI: https://doi.org/10.4143/crt.2014.46.2.178
-
-
Abstract
PDFPubReaderePub
- Purpose
The accurate and timely diagnosis of malignant pleural effusion (MPE) in lung cancer patients is important because MPE has a poor prognosis and is classified as stage IV disease. Molecular biomarkers for pleural effusion, such as circulating extracellular microRNAs (miRNAs) isolated from pleural fluid, may help in the diagnosis of MPE. The present study examined whether miRNAs that are deregulated in lung cancer (miR-134, miR-185, and miR-22) can serve as diagnostic markers for lung adenocarcinoma-associated MPE (LA-MPE). Materials and MethodsReal-time reverse transcription quantitative polymerase chain reaction was used to measure the expression of the three miRNAs in samples from 87 patients with pleural effusion comprising 45 LA-MPEs and 42 benign pleural effusions (BPEs). The area under the receiver operating characteristic curve (AUC) was then used to evaluate the diagnostic performance of each of the three miRNAs and compare it with that of the common tumor marker, carcinoembryonic antigen (CEA). ResultsThe expression of all three miRNAs was significantly lower in LA-MPE than in BPE (p <0.001). The AUCs for miR-134, miR-185, miR-22, and CEA were 0.721, 0.882, 0.832, and 0.898, respectively. Combining CEA with the three miRNAs increased the diagnostic performance, yielding an AUC of 0.942 (95% confidence interval, 0.864 to 0.982), with a sensitivity of 91.9% and a specificity of 92.5%. ConclusionThe present study suggests that the expression levels of circulating extracellular miR-134, miR-185, and miR-22 in patients with pleural effusion may have diagnostic value when differentiating between LA-MPE and BPE.
-
Citations
Citations to this article as recorded by - Key methodological challenges in detecting circulating miRNAs in different biofluids
Chitra Mestry, Tester F Ashavaid, Swarup AV Shah
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.2023; 60(1): 14. CrossRef - MiRNAs in Lung Adenocarcinoma: Role, Diagnosis, Prognosis, and Therapy
Yongan Song, Leonardo Kelava, István Kiss
International Journal of Molecular Sciences.2023; 24(17): 13302. CrossRef - High Diagnostic and Prognostic Value of miRNAs Compared with the Carcinoembryonic
Antigen As A Traditional Tumor Marker
Neda Yaghoubi , Farnaz Zahedi Avval , Majid Khazaei, Amirhossein Sahebkar , Seyed Hamid Aghaee-Bakhtiari
Anti-Cancer Agents in Medicinal Chemistry.2022; 22(2): 206. CrossRef - Diagnostic utility of pleural cell-free nucleic acids in undiagnosed pleural effusions
Wen Zhao, Xi-Shan Cao, Yu-Ling Han, Xu-Hui Wen, Wen-Qi Zheng, Zhi-De Hu
Clinical Chemistry and Laboratory Medicine (CCLM).2022; 60(10): 1518. CrossRef - Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma
Xiaolu Huang, Huixin Zhou, Xiang Yang, Wenjing Shi, Lijuan Hu, Junjun Wang, Fan Zhang, Fanggui Shao, Meijuan Zhang, Feng Jiang, Yumin Wang
Journal of Clinical Laboratory Analysis.2022;[Epub] CrossRef - Molecular testing on serous effusions
Ben Davidson
Diagnostic Cytopathology.2021; 49(5): 640. CrossRef - Diving into the Pleural Fluid: Liquid Biopsy for Metastatic Malignant Pleural Effusions
Maria Alba Sorolla, Anabel Sorolla, Eva Parisi, Antonieta Salud, José M. Porcel
Cancers.2021; 13(11): 2798. CrossRef - Four plasma miRNAs act as biomarkers for diagnosis and prognosis of non‑small cell lung cancer
He-Guo Jiang, Chun-Hua Dai, Ya-Ping Xu, Qian Jiang, Xian-Bin Xia, Yang Shu, Jian Li
Oncology Letters.2021;[Epub] CrossRef - Molecular testing on serous effusion: An update
Saumya Sahu, Parikshaa Gupta, Pranab Dey
Cytojournal.2021; 18: 35. CrossRef - Non-coding RNA and lung cancer progression
Afeez Adekunle Ishola, Anita Silas La’ah, Hung Dinh Le, Viet Quoc Nguyen, Yi-Ping Yang, Shih-Jie Chou, Hsiao-Yun Tai, Chian-Shiu Chien, Mong-Lien Wang
Journal of the Chinese Medical Association.2020; 83(1): 8. CrossRef - Role of microRNAs as Clinical Cancer Biomarkers for Ovarian Cancer: A Short Overview
Cristina Elena Staicu, Dragoș-Valentin Predescu, Călin Mircea Rusu, Beatrice Mihaela Radu, Dragos Cretoiu, Nicolae Suciu, Sanda Maria Crețoiu, Silviu-Cristian Voinea
Cells.2020; 9(1): 169. CrossRef - microRNA exchange via extracellular vesicles in cancer
Luyen Tien Vu, Jinhua Gong, Thach Tuan Pham, Yeokyeong Kim, Minh T. N. Le
Cell Proliferation.2020;[Epub] CrossRef - MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions
Kimberly A. Birnie, Cecilia M. Prêle, Arthur W. (Bill) Musk, Nicholas de Klerk, Y. C. Gary Lee, Deirdre Fitzgerald, Richard J. N. Allcock, Philip J. Thompson, Jenette Creaney, Bahareh Badrian, Steven E. Mutsaers
Disease Markers.2019; 2019: 1. CrossRef - Combination of DNA ploidy analysis and miR-21 or miR-24 in screening malignant pleural effusion
Chongmei Liu, Liuyan Huang, Xuechun Zhang, Juan Yang
Interactive CardioVascular and Thoracic Surgery.2018; 26(3): 376. CrossRef - Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion
Yakun Wen, Yong Wang, Zhenchuan Xing, Zongjian Liu, Ziliang Hou
Cell Cycle.2018; 17(24): 2819. CrossRef - Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion: a validation study and meta-analysis
Mei Feng, Jing Zhu, Liqun Liang, Ni Zeng, Yanqiu Wu, Chun Wan, Yongchun Shen, Fuqiang Wen
International Journal of Clinical Oncology.2017; 22(2): 283. CrossRef - miR-134: A Human Cancer Suppressor?
Jing-Yu Pan, Feng Zhang, Cheng-Cao Sun, Shu-Jun Li, Guang Li, Feng-Yun Gong, Tao Bo, Jing He, Rui-Xi Hua, Wei-Dong Hu, Zhan-Peng Yuan, Xin Wang, Qi-Qiang He, De-Jia Li
Molecular Therapy - Nucleic Acids.2017; 6: 140. CrossRef - Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)
Jingyu Wang, Yuan Li, Meiman Ding, Honghe Zhang, Xiaoming Xu, Jinlong Tang
International Journal of Oncology.2017; 50(2): 345. CrossRef - MicroRNA-134 modulates glioma cell U251 proliferation and invasion by targeting KRAS and suppressing the ERK pathway
Yuguang Zhao, Dong Pang, Cui Wang, Shijiang Zhong, Shuang Wang
Tumor Biology.2016; 37(8): 11485. CrossRef - MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features
Ruma Dey Ghosh, Sangeeta Ghuwalewala, Pijush Das, Sapan Mandloi, Sk Kayum Alam, Jayanta Chakraborty, Sajal Sarkar, Saikat Chakrabarti, Chinmoy Kumar Panda, Susanta Roychoudhury
Scientific Reports.2016;[Epub] CrossRef - Cell‐free microRNAs in blood and other body fluids, as cancer biomarkers
Blanca Ortiz‐Quintero
Cell Proliferation.2016; 49(3): 281. CrossRef - Clinical relevance of circulating cell-free microRNAs in ovarian cancer
Koji Nakamura, Kenjiro Sawada, Akihiko Yoshimura, Yasuto Kinose, Erika Nakatsuka, Tadashi Kimura
Molecular Cancer.2016;[Epub] CrossRef - MicroRNA-432 functions as a tumor suppressor gene through targeting E2F3 and AXL in lung adenocarcinoma
Ling Chen, Guangming Kong, Chuantao Zhang, Hongyan Dong, Cuicui Yang, Guanhua Song, Chengye Guo, Lin Wang, Hongsheng Yu
Oncotarget.2016; 7(15): 20041. CrossRef - Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics
Ningning Yang, Nsikak R. Ekanem, Clement A. Sakyi, Sidhartha D. Ray
Advanced Drug Delivery Reviews.2015; 81: 62. CrossRef - Reduced expression of microRNA-134 correlates with malignancy and poor prognosis in human glioma
Jianfeng Zhong, Bing Li
Journal of Clinical Neuroscience.2015; 22(3): 583. CrossRef - 2015 update on the diagnosis and management of neoplastic pericardial disease
Chiara Lestuzzi, Massimiliano Berretta, Witold Tomkowski
Expert Review of Cardiovascular Therapy.2015; 13(4): 377. CrossRef - Extracellular microRNAs in bronchoalveolar lavage samples from patients with lung diseases as predictors for lung cancer
Grit Rehbein, Bernd Schmidt, Michael Fleischhacker
Clinica Chimica Acta.2015; 450: 78. CrossRef
-
16,480
View
-
138
Download
-
38
Web of Science
-
27
Crossref
|
KCA
