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Expression of High Mobility Group Protein Family [HMGI(Y) and HMGI-C] in Human Breast Cancer
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Jin Woo Ryu, Duck Hwan Kim, Hyung Sik Shin, Eun Sook Nam, Hyung Jee Kim
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Cancer Res Treat. 2001;33(4):281-285. Published online August 31, 2001
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DOI: https://doi.org/10.4143/crt.2001.33.4.281
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 Abstract
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- PURPOSE
Breast cancer results from the progressive accumulation of a series of genetic alterations leading to neoplastic transformation. Recent studies have shown that a) HMGI proteins play an important role in the regulation of chromatin structure and function and b) the expression of aberrant HMGI [HMGI(Y) and HMGI-C] proteins is generally correlated with malignant tumors. We tried to define the function of HMGI in carcinogenesis and we compare the expression of HMGI with known clinicopathologic parameters.
MATERIALS AND METHODS
Using Reverse transcriptase-polymerase chain reaction (RT-PCR), we determined the expression of HMGI mRNA in 60 primary malignant tumors, 20 normal tissue, 13 benign tumors, and four ductal carcinoma in situ. Immunohistochemical staining of p53, ER, PR, and clinicopathological parameters were evaluated.
RESULTS
The expression of the HMGI(Y) mRNA increased more in malignant tissue (90%, 54 of 60) than in benign (76.9%) and normal (65%) tissues (p=0.031). The expression of HMGI-C mRNA was visible only in malignant (48.4%, 29 of 60) and benign (23.1%, 3 of 13) tumors. The expression of HMGI-C mRNA increased more in malignant tumors than in benign tumors (p<0.001). In invasive ductal tumors (n=50), the expression of HMGI-C mRNA was observed more in high grade tumors (grade 3~81.3%, grade 1, 2~32.4%) (p=0.005). Among the prognostic parameters, only the number of mitotic figures was related to the expression of HMGI-C mRNA (p=0.046).
CONCLUSION
These results suggest that a) HMGI-C gene may be correlated with the formation of breast tumors and b) the expression of HMGI-C gene may be of pathogenetic and prognostic importance in human breast cancer.
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Citations
Citations to this article as recorded by  - Cytoplasmic levels of high mobility group A2 determine survival prognoses in breast cancer patients
Thorsten Heilmann, Florian Vondung, Christoph Borzikowsky, Sandra Krüger, Mohamed Elessawy, Ibrahim Alkatout, Antonia Wenners, Maret Bauer, Wolfram Klapper, Christoph Röcken, Nicolai Maass, Christian Schem, Anna Trauzold
The International Journal of Biological Markers.2020; 35(2): 20. CrossRef - High Mobility Group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression
Riccardo Sgarra, Silvia Pegoraro, Gloria Ros, Carlotta Penzo, Eusebio Chiefari, Daniela Foti, Antonio Brunetti, Guidalberto Manfioletti
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2018; 1869(2): 216. CrossRef
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Recurrence after Curative Resection for Gastric Cancer
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Jin Woo Ryu, Young Jin Kim, Shin Kon Kim
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J Korean Cancer Assoc. 1996;28(1):19-27.
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Abstract
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- In an effort to help making plans for follow-up and management in patients after initial operation of gastric cancer, ninty two patients who were found to have recurrence after initial curative resection for gastric cancer at the Department of Surgery, Chonnam University Hospital from January 1985 to December 1994 were studied for the recurrence pattern of gastric cancer. Recurrences were detected based on clinical, radiological, endoscopic findings and by operation, and these results were testified by chi square test. The results were as follows; 1) In 92 patients, total of 108 recurrences were identified. 88.0% of total recurrences were intraabdominal.The most common site of recurrence was peritoneal(38.9%), and next was loco-regional(35.2%), liver(13.9%) and extraperitoneal metastasis(12.0%), in order of frequency. 2) Liver metastasis was more frequent in cancers located in antrum(22.0%, p=0.016l), in well differentiated tumor(38.9%, p=0.0032), in Borrmann type II(50.0%,p=0;0044), and in metastasis to Group 1 regional lymph node(29.0%, p=0.0106). 3) Peritoneal recurrence tended to occur more frequently in poorly differentiated cancers (p = 0.047). 4) Extraperitoneal metastasis was more frequent in stage IIIb(23.0%,p=0.0432). 5) In 92 patients, 13 patients received reoperation(14.1%). Curative reoperation could be carried out in 5 cases(5.4%). One patient had liver metastasis and four patients had locoregional recurrence. 6) There was no differences in patterns of recurrence by DNA ploidy patterns. Recurrence patterns after curative resection of gastric cancer showed different features on celllular differentiation of primary tumor, site of primary tumor, stage, and lymph node metastasis. Therefore, this findings may be helpful in planning for postoperative follow-up and adjuvant therapy, and early detection of radically resectable locoregional recurrences.
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