Cancer Research and Treatment

Hyo Chae Paik

2 Articles

Lung and Thoracic cancer

The Role of Adjuvant Therapy Following Surgical Resection of Small Cell Lung Cancer: A Multi-Center Study: Seong Yong Park, Samina Park, Geun Dong Lee, Hong Kwan Kim, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Tae Hee Hong, Yong Soo Choi, Jhingook Kim, Jong Ho Cho, Young Mog Shim, Jae Ill Zo, Kwon Joong Na, In Kyu Park, Chang Hyun Kang, Young-Tae Kim, Byung Jo Park, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik; Cancer Res Treat. 2023;55(1):94-102. Published online June 9, 2022; DOI: https://doi.org/10.4143/crt.2022.290

Abstract PDF Supplementary Material PubReader ePub

Purpose
This multi-center, retrospective study was conducted to evaluate the long-term survival in patients who underwent surgical resection for small cell lung cancer (SCLC) and to identify the benefit of adjuvant therapy following surgery.
Materials and Methods
The data of 213 patients who underwent surgical resection for SCLC at four institutions were retrospectively reviewed. Patients who received neoadjuvant therapy or an incomplete resection were excluded.
Results
The mean patient age was 65.29±8.93 years, and 184 patients (86.4%) were male. Lobectomies and pneumonectomies were performed in 173 patients (81.2%), and 198 (93%) underwent systematic mediastinal lymph node dissections. Overall, 170 patients (79.8%) underwent adjuvant chemotherapy, 42 (19.7%) underwent radiotherapy to the mediastinum, and 23 (10.8%) underwent prophylactic cranial irradiation. The median follow-up period was 31.08 months (interquartile range, 13.79 to 64.52 months). The 5-year overall survival (OS) and disease-free survival were 53.4% and 46.9%, respectively. The 5-year OS significantly improved after adjuvant chemotherapy in all patients (57.4% vs. 40.3%, p=0.007), and the survival benefit of adjuvant chemotherapy was significant in patients with negative node pathology (70.8% vs. 39.7%, p=0.004). Adjuvant radiotherapy did not affect the 5-year OS (54.6% vs. 48.5%, p=0.458). Age (hazard ratio [HR], 1.032; p=0.017), node metastasis (HR, 2.190; p < 0.001), and adjuvant chemotherapy (HR, 0.558; p=0.019) were associated with OS.
Conclusion
Adjuvant chemotherapy after surgical resection in patients with SCLC improved the OS, though adjuvant radiotherapy to the mediastinum did not improve the survival or decrease the locoregional recurrence rate.

Citations

Citations to this article as recorded by

Application of postoperative adjuvant radiotherapy in limited-stage small cell lung cancer: A systematic review and meta-analysis
Chuanhao Zhang, Genghao Zhao, Huajian Wu, Jianing Jiang, Wenyue Duan, Zhijun Fan, Zhe Wang, Ruoyu Wang
Radiotherapy and Oncology.2024; 193: 110123. CrossRef
A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection
Sevcan Atay
Cancers.2023; 15(21): 5219. CrossRef

5,574 View
138 Download
2 Web of Science
2 Crossref

Bilateral Mediastinal Lymph Nodes Dissection via Median Sternotomy in Lung Cancer: Man Sil Park, Doo Yun Lee, Gi Man Bae, Hyo Chae Paik, Sang Jin Kim; J Korean Cancer Assoc. 1994;26(1):106-113.

Abstract PDF: Prom July 1992 through May 1993, 32 lung cancer patients underwent bilateral mediastinal lymph node dissection in conjunction with pulmonary resection via median sternotomy with or without thoracotomy. Operations were limited to clinically negative contralateral mediastinal lymph nodes metastasis. The locations of cancer were in the right upper lobe in 7 patients, right middle lobe in 2 patients, right lower lobe in 11 patients, left upper lobe in 6 patients, and in left lower lobe in 6 patients. Histological diagnosis was epidermoid cell carcinoma in 12 pa- tients, adenocarcinoma in 12 patients, bronchioloalveolar cell carcinoma in 3 patients, adenosquamous cell carcinoma in 2 patients, and one case each of small cell carcinama, double lung cancer(adenocarcinoma and small cell carcinoma), and intraepithelial dysplasia after radiotherapy. Right pneumonectomy was performed in 10 patients, left pneumonectomy in 7 patients, right lower and middle lobectomy in 4 patients, right upper and middle lobectomy in 3 patients, left lower lobectomy in 4 patients, right upper lobectomy in 2 patients and left upper lobectomy in 2 patients. Operative approaches were as follows; 21 cases of median sternotomy alone, 2 cases of median sternotomy with right posterolateral thoracotomy, 4 cases of median sternotomy with left anterolateral thoracotomy, 4 cases of median sternotomy with left posterolateral thoracotomy and I case of thoracoscopic left upper lobectomy and median sternotomy, Six patients(one patient with right upper lobe lesion and five patients with right lower lobe lesion) were proved to have contralateral mediastinal lymph node metastases which were not recognized preoperatively. There were 2 early postoperative deaths which were not related to the operation. Median sternotomy in lung cancer surgery provide bilateral mediastinal lymph nodes dissection which is useful in postoperative staging and postoperative adiuvant therapy.

2,556 View
19 Download

Author index