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Hee Young Na 2 Articles
PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs
Yujun Park, Jiwon Koh, Hee Young Na, Yoonjin Kwak, Keun-Wook Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee
Cancer Res Treat. 2020;52(3):661-670.   Published online January 10, 2020
DOI: https://doi.org/10.4143/crt.2019.718
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
We provide a comparison between 22C3 pharmDx and SP263 assay, for evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC) patients.
Materials and Methods
The PD-L1 immunohistochemistry by 22C3 pharmDx and SP263 assays was performed in the center of the tumor (CT) and invasive margin (IM) in 379 GC tissues using tissue microarrays and interpreted as combined positive score (CPS) and tumor proportion score (TPS). Of the total samples, 55 samples were independently reviewed by five pathologists.
Results
The two assays showed a high correlation in both the CPS and TPS. At a CPS ≥ 1 cut-off, 219 (57.8%) and 231 (60.9%) GCs were positive for PD-L1 with the 22C3 and SP263 assays, and at ≥ 10 cut-off, 37 (9.8%) and 36 (9.5%) GCs were positive, respectively. The overall percent agreement (OPA) was greater than 90% with CPS ≥ 1 and ≥ 10 cut-offs, and TPS ≥ 1% and ≥ 10% cut-offs. There was higher OPA between the two assays with a CPS cut-off ≥ 10 (99.2%) than ≥ 1 (94.7%). The percent agreement between the CT and IM was higher with a CPS cut-off ≥ 10 (92.9%) than ≥ 1 (77.6%). Patient with positive expression at CPS ≥ 5 cut-off had a significantly better outcomes in both assays. Interobserver variability among five pathologists was higher than the assay variability.
Conclusion
Two assays for PD-L1 expression in GC showed high agreement. These results provide guidance for selecting eligible patients with GC for pembrolizumab treatment.

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  • Programmed death ligand-1 (PD-L1) clone 22C3 expression in resected colorectal cancer as companion diagnostics for immune checkpoint inhibitor therapy: A comparison study and inter-rater agreement evaluation across proposed cut-offs and predictive (TPS, C
    Dordi Lea, Claudia Zaharia, Kjetil Søreide
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    BMC Research Notes.2024;[Epub]     CrossRef
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    Diagnostics.2024; 14(10): 1007.     CrossRef
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    J. Bos, T.S. Groen-van Schooten, C.P. Brugman, F.S. Jamaludin, H.W.M. van Laarhoven, S. Derks
    Cancer Treatment Reviews.2024; 127: 102737.     CrossRef
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    Gastric Cancer.2024; 27(4): 819.     CrossRef
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    Haruki Ogawa, Hiroyuki Abe, Koichi Yagi, Yasuyuki Seto, Tetsuo Ushiku
    Gastric Cancer.2024; 27(4): 802.     CrossRef
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    Journal of Pathology and Translational Medicine.2024; 58(3): 103.     CrossRef
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    Samuel J. Klempner, Eric S. Cowden, Samuel L. Cytryn, Matteo Fassan, Hisato Kawakami, Hideaki Shimada, Laura H. Tang, Daniel-Christoph Wagner, Yasushi Yatabe, Alexander Savchenko, Jennifer Salcius, Dorhyun Johng, Jing Chen, Giuliana Montenegro, Markus Moe
    JCO Precision Oncology.2024;[Epub]     CrossRef
  • PD-L1 expression in squamous cervical carcinomas of Mozambican women living with or without HIV
    Lucília Lovane, Satish Tulsidás, Carla Carrilho, Christina Karlsson
    Scientific Reports.2024;[Epub]     CrossRef
  • First-line immune checkpoint inhibitors in low programmed death-ligand 1-expressing population
    Feiyang Zhang, Guoming Chen, Yixin Yin, Xiaojiang Chen, Runcong Nie, Yingbo Chen
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Concordance of PD-L1 status in primary gastroesophageal adenocarcinoma and matched peritoneal metastases: a single institution study
    V. Massa, F. Signorini, F. Salani, M.E. Filice, G. Grelli, P. Lippolis, P. Faviana, V. Genovesi, S. Santi, C. Vivaldi, S. Cesario, A. Bertolucci, C. Cremolini, V. Nardini, G. Masi, C. Ugolini, L. Fornaro
    ESMO Gastrointestinal Oncology.2024; 5: 100089.     CrossRef
  • A Phase 1a/1b Dose Escalation/Expansion Study of the Anti-PD-1 Monoclonal Antibody Nofazinlimab in Chinese Patients with Solid Tumors or Lymphoma
    Jifang Gong, Ye Guo, Yanqiao Zhang, Yi Ba, Tong Chen, Wei Li, Caicun Zhou, Mengzhao Wang, Haiyan Yang, Yuhong Zhou, Qiqing Cai, Ziping Wang, Gang Huang, Wei Zhang, Rila Su, Zhongheng Cai, Zenglian Yue, Jinzhou Dou, Peiqi Li, Rachel Wu, Archie N. Tse, Lin
    Targeted Oncology.2024; 19(5): 723.     CrossRef
  • Immune checkpoint inhibitors in advanced gastroesophageal adenocarcinoma: a series of patient-level meta-analyses in different programmed death-ligand 1 subgroups
    A.G. Leone, A.S. Mai, K.Y. Fong, D.W.T. Yap, K. Kato, E. Smyth, M. Moehler, J.T.C. Seong, R. Sundar, J.J. Zhao, F. Pietrantonio
    ESMO Open.2024; 9(11): 103962.     CrossRef
  • HIPEC for Metastatic Gastric Cancer: Moving the Needle Towards 3-Year Survival
    Neal Bhutiani, Y. David Seo, Kristen A. Robinson, Michael G. White, Naruhiko Ikoma, Paul F. Mansfield, Jenny J. Li, Mariela Blum Murphy, Jaffer A. Ajani, Brian D. Badgwell
    European Journal of Surgical Oncology.2024; : 108790.     CrossRef
  • Biomarkers for Predicting Response to Personalized Immunotherapy in Gastric Cancer
    Moonsik Kim, Ji Yun Jeong, An Na Seo
    Diagnostics.2023; 13(17): 2782.     CrossRef
  • Development of an automated combined positive score prediction pipeline using artificial intelligence on multiplexed immunofluorescence images
    Abhishek Vahadane, Shreya Sharma, Devraj Mandal, Madan Dabbeeru, Josephine Jakthong, Miguel Garcia-Guzman, Shantanu Majumdar, Chung-Wein Lee
    Computers in Biology and Medicine.2023; 152: 106337.     CrossRef
  • CT-based delta radiomics in predicting the prognosis of stage IV gastric cancer to immune checkpoint inhibitors
    Jiazheng Li, Zifan Chen, Yang Chen, Jie Zhao, Meng He, Xiaoting Li, Li Zhang, Bin Dong, Xiaotian Zhang, Lei Tang, Lin Shen
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Efficacy of PD-1/PD-L1 inhibitors in gastric or gastro-oesophageal junction cancer based on clinical characteristics: a meta-analysis
    Gengwei Huo, Wenjie Liu, Peng Chen
    BMC Cancer.2023;[Epub]     CrossRef
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    Gastric Cancer.2023; 26(3): 393.     CrossRef
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    Hyun Jung Kwon, Yujun Park, Soo Kyung Nam, Enoch Kang, Ka‐Kyung Kim, Inhae Jeong, Yoonjin Kwak, Jeesun Yoon, Tae‐Yong Kim, Keun‐Wook Lee, Do‐Youn Oh, Seock‐Ah Im, Seong‐Ho Kong, Do Joong Park, Hyuk‐Joon Lee, Hyung‐Ho Kim, Han‐Kwang Yang, Hye Seung Lee
    Cancer Medicine.2023; 12(9): 10371.     CrossRef
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    Marie E. Robert, Josef Rüschoff, Bharat Jasani, Rondell P. Graham, Sunil S. Badve, Manuel Rodriguez-Justo, Liudmila L. Kodach, Amitabh Srivastava, Hanlin L. Wang, Laura H. Tang, Giancarlo Troncone, Federico Rojo, Benjamin J. Van Treeck, James Pratt, Iryna
    Modern Pathology.2023; 36(5): 100154.     CrossRef
  • Heterogeneous distribution pattern of CD3+ tumor-infiltrated lymphocytes (TILs) and high combined positive score (CPS) favored the prognosis of resected early stage small-cell lung cancer
    Liang Zhu, Guoping Cheng, Meijuan Wu, Ming Chen, Ying Jin
    Translational Oncology.2023; 34: 101697.     CrossRef
  • The Role of Immunotherapy in Esophageal and Gastric Cancer
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    Clinical Colorectal Cancer.2023; 22(2): 175.     CrossRef
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    Luca Licata, Marco Mariani, Federico Rossari, Giulia Viale, Giulia Notini, Matteo Maria Naldini, Carlo Bosi, Marta Piras, Matteo Dugo, Giampaolo Bianchini
    The Breast.2023; 69: 330.     CrossRef
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    Satoshi Yamashita, Hiroyuki Abe, Hiroharu Yamashita, Koichi Yagi, Yasuyuki Seto, Tetsuo Ushiku
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    Expert Review of Molecular Diagnostics.2023; 23(10): 863.     CrossRef
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    Cancer Medicine.2023; 12(18): 18633.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development
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Cancer Res Treat. 2019;51(2):632-648.   Published online August 1, 2018
DOI: https://doi.org/10.4143/crt.2018.060
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model.
Materials and Methods
AOM/DSS-treated male and female mice were sacrificed at weeks 2, 10, and 16, to assess estrogen effects on colitis and carcinogenesis. Macroscopic and histologic severity of colitis and Western blot and quantitative real-time polymerase chain reaction were evaluated, to measure inflammatory mediators and cytokines.
Results
Compared with AOM/DSS-treated male mice (M-AOM/DSS group), AOM/DSS-treated male mice with estradiol administration (M-AOM/DSS+estr group) displayed at week 2 significantly decreased severity of colitis. At weeks 10 and 16, AOM/DSS-treated female mice (F-AOM/DSS group) and the M-AOM/DSS+estr group showed significantly lower tumor multiplicity compared with the M-AOM/DSS group. At week 2, F-AOM/DSS group had a lower level of nuclear factor-κB (NF-κB) expression and higher level of nuclear factor erythroid 2-related factor 2 (Nrf2) expression, compared to the M-AOM/DSS group. At week 2, expression levels of NF-κB and its related mediators decreased in the M-AOM/DSS+estr group, while levels of Nrf2 and Nrf2-related anti-oxidant enzymes increased. In addition, estradiol significantly increased Nod-like receptor protein 3 (NLRP3) inflammasome expressions in AOM/DSS-treated male mice. In contrast, at weeks 10 and 16, Nrf2 and its-related anti-oxidant enzymes and NLRP3 inflammasome were highly expressed in M-AOM/DSS group and in F-AOM/DSS group, who developed cancer.
Conclusion
The data suggest that estradiol inhibits the initiation of CRC by regulating Nrf2-related pathways. Moreover, these imply the dual role of Nrf2 and NLRP3 inflammasome, including promotion of tumor progression upon tumor initiation.

Citations

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  • Sex Difference of Colon Adenoma Pathway and Colorectal Carcinogenesis
    Yonghoon Choi, Nayoung Kim
    The World Journal of Men's Health.2024; 42(2): 256.     CrossRef
  • Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis
    Zihong Wu, Yuqing Huang, Renyi Zhang, Chuan Zheng, Fengming You, Min Wang, Chong Xiao, Xueke Li
    Cell Communication and Signaling.2024;[Epub]     CrossRef
  • Gα12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis
    Jihoon Tak, Quanxi An, Sang Gil Lee, Chang Hoon Lee, Sang Geon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies
    Yair Rodríguez-Santiago, Claudia Angelica Garay-Canales, Karen Elizabeth Nava-Castro, Jorge Morales-Montor
    Biology of Sex Differences.2024;[Epub]     CrossRef
  • 17β-estradiol in colorectal cancer: friend or foe?
    Zihong Wu, Chong Xiao, Jiamei Wang, Min Zhou, Fengming You, Xueke Li
    Cell Communication and Signaling.2024;[Epub]     CrossRef
  • Sexual dimorphism of colorectal cancer in humans and colorectal tumors in a murine model
    Yair Rodríguez-Santiago, Luis Ignacio Terrazas-Valdés, Karen Elizabeth Nava-Castro, Víctor Hugo Del Río-Araiza, Claudia Angélica Garay-Canales, Jorge Morales-Montor
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Sex difference in human diseases: mechanistic insights and clinical implications
    Yuncong Shi, Jianshuai Ma, Sijin Li, Chao Liu, Yuning Liu, Jie Chen, Ningning Liu, Shiming Liu, Hui Huang
    Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
  • Tocotrienol suppresses colitis-associated cancer progression through TLR4 signaling in a mouse model of colorectal cancer
    Qian Li, Shujing Zhang, Qinghong Zhou, Chenxi Gu, Yinghua Liu, Jing Zhang, Jingshu Zhang
    Current Research in Toxicology.2024; 7: 100196.     CrossRef
  • Ninjurin1 deficiency differentially mitigates colorectal cancer induced by azoxymethane and dextran sulfate sodium in male and female mice
    Chin‐Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Eun Hye Kim, Sungchan Ha, Eun Shin, Hoon Choi, Kyu‐Won Kim, Sejin Jeon, Goo Taeg Oh, Yeong‐Jae Seok
    International Journal of Cancer.2024;[Epub]     CrossRef
  • Sexual dimorphism of gut microbiota in colorectal cancer
    Zihong Wu, Ziming Wang, Jiamei Wang, Chong Xiao, Fengming You, Xueke Li
    Chinese Science Bulletin.2024;[Epub]     CrossRef
  • Direct and indirect effects of estrogens, androgens and intestinal microbiota on colorectal cancer
    Zihong Wu, Yi Sun, Wenbo Huang, Zhenzhen Jin, Fengming You, Xueke Li, Chong Xiao
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Estrogen-related differences in antitumor immunity and gut microbiome contribute to sexual dimorphism of colorectal cancer
    Georgia Lattanzi, Federica Perillo, Angélica Díaz-Basabe, Bruna Caridi, Chiara Amoroso, Alberto Baeri, Elisa Cirrincione, Michele Ghidini, Barbara Galassi, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Maurizio Vecchi, Flavio Caprioli, Federica Facciott
    OncoImmunology.2024;[Epub]     CrossRef
  • Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation
    Shoko Yamashita, Chie Takasu, Yuji Morine, Hiroki Ishibashi, Tetsuya Ikemoto, Hiroki Mori, Shinichiro Yamada, Takeshi Oya, Koichi Tsuneyama, Mitsuo Shimada
    Journal of Hepato-Biliary-Pancreatic Sciences.2023; 30(4): 462.     CrossRef
  • Changes in Gut Microbiome upon Orchiectomy and Testosterone Administration in AOM/DSS-Induced Colon Cancer Mouse Model
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Ha-Na Lee
    Cancer Research and Treatment.2023; 55(1): 196.     CrossRef
  • Influence of location-dependent sex difference on PD-L1, MMR/MSI, and EGFR in colorectal carcinogenesis
    Jina Choi, Nayoung Kim, Ryoung Hee Nam, Jin Won Kim, Chin-Hee Song, Hee Young Na, Gyeong Hoon Kang, Alvaro Galli
    PLOS ONE.2023; 18(2): e0282017.     CrossRef
  • Anti–PD-L1 Antibody and/or 17β-Estradiol Treatment Induces Changes in the Gut Microbiome in MC38 Colon Tumor Model
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Jina Choi, Ha-Na Lee
    Cancer Research and Treatment.2023; 55(3): 894.     CrossRef
  • The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques
    Yujia Song, Tengda Huang, Hongyuan Pan, Ao Du, Tian Wu, Jiang Lan, Xinyi Zhou, Yue Lv, Shuai Xue, Kefei Yuan
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • ATP ion channel P2X7 receptor as a regulatory molecule in the progression of colorectal cancer
    Cheng Zuo, Yong-sheng Xu, Peng-fei He, Wen-jun Zhang
    European Journal of Medicinal Chemistry.2023; 261: 115877.     CrossRef
  • Estrogen plays an important role by influencing the NLRP3 inflammasome
    Wanglin Dong, Qianwen Peng, Zhuoxin Liu, Zhenxing Xie, Xiajun Guo, Yuanyuan Li, Chaoran Chen
    Biomedicine & Pharmacotherapy.2023; 167: 115554.     CrossRef
  • NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers
    Yujie Zhou, Songyan Yu, Wenyong Zhang
    International Journal of Molecular Sciences.2023; 24(19): 14511.     CrossRef
  • Role of gonadally synthesized steroid hormones in the colorectal cancer microenvironment
    Liu Wenxuan, Li Liu, Lilong Zhang, Zhendong Qiu, Zhongkai Wu, Wenhong Deng
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • A novel targeted approach to delineate a role for estrogen receptor-β in ameliorating murine mammary tumor-associated neuroinflammation
    Corena V. Grant, Kathryn L. G. Russart, Leah M. Pyter
    Endocrine.2022; 75(3): 949.     CrossRef
  • Association of Type 1 diabetes with ulcerative colitis in BALB/c mice: Investigations on sex‐specific differences
    Shivani Singla, Chittaranjan Sahu, Gopabandhu Jena
    Journal of Biochemical and Molecular Toxicology.2022;[Epub]     CrossRef
  • Lactobacillus paracasei BD5115-Derived 2-Hydroxy-3-Methylbutyric Acid Promotes Intestinal Epithelial Cells Proliferation by Upregulating the MYC Signaling Pathway
    Zhenyi Qiao, Xiaohua Wang, Chaoyue Wang, Jin Han, Weiwei Qi, Huanchang Zhang, Zhenmin Liu, Chunping You
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Combination treatment with 17β-estradiol and anti-PD-L1 suppresses MC38 tumor growth by reducing PD-L1 expression and enhancing M1 macrophage population in MC38 colon tumor model
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Jin Won Kim, Hee Young Na, Ha-Na Lee
    Cancer Letters.2022; 543: 215780.     CrossRef
  • Sex/Gender-related Differences in Reflux Esophagitis and Peptic Ulcer Disease in Terms of Sex Hormones
    Nayoung Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(2): 157.     CrossRef
  • Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)
    Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu, Xin Lu
    European Journal of Medical Research.2022;[Epub]     CrossRef
  • Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms
    Suhuan Mei, Haile Ma, Xiumin Chen
    Food and Chemical Toxicology.2021; 149: 111997.     CrossRef
  • Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells
    Emiliano Panieri, Luciano Saso
    Antioxidants & Redox Signaling.2021; 34(18): 1428.     CrossRef
  • Endogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta-analysis
    Emmanouil Bouras, Christopher Papandreou, Ioanna Tzoulaki, Konstantinos K. Tsilidis
    Discover Oncology.2021;[Epub]     CrossRef
  • Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Changhee Kang, Jae Young Jang, Heewon Nho, Eun Shin, Ha-Na Lee
    Journal of Cancer Prevention.2021; 26(1): 41.     CrossRef
  • Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jeong Eun Yu, Heewon Nho, Young-Joon Surh
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer
    Changhee Kang, Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jeong Eun Yu, Heewon Nho, Jin A. Choi, Jin Won Kim, Hee Young Na, Ha-Na Lee, Young-Joon Surh
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses
    Kayla Jaye, Chun Guang Li, Deep Jyoti Bhuyan
    Critical Reviews in Oncology/Hematology.2021; 165: 103429.     CrossRef
  • Sex- and Gender-related Issues of Gut Microbiota in Gastrointestinal Tract Diseases
    Nayoung Kim
    The Korean Journal of Gastroenterology.2021; 78(1): 9.     CrossRef
  • Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives
    Ilaria Ditonno, Giuseppe Losurdo, Maria Rendina, Maria Pricci, Bruna Girardi, Enzo Ierardi, Alfredo Di Leo
    Current Oncology.2021; 28(6): 4256.     CrossRef
  • Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex
    Ju Yup Lee, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Sun Min Lee, Chin-Hee Song, Geun Kim, Hee Young Na, Yoon Jin Choi, Jin Joo Kim, Dong Ho Lee
    Journal of Neurogastroenterology and Motility.2020; 26(1): 106.     CrossRef
  • Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
    Linnea Hases, Rajitha Indukuri, Madeleine Birgersson, Trang Nguyen-Vu, Rodrigo Lozano, Ashish Saxena, Johan Hartman, Jonna Frasor, Jan-Åke Gustafsson, Pekka Katajisto, Amena Archer, Cecilia Williams
    Cancer Letters.2020; 492: 54.     CrossRef
  • 17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Ha-Na Lee, Young-Joon Surh
    Scientific Reports.2020;[Epub]     CrossRef
  • A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis
    Haitao Chen, Fan Zhang, Jin Zhang, Xinjie Zhang, Yong Guo, Qinghua Yao
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner
    L. Hases, A. Archer, R. Indukuri, M. Birgersson, C. Savva, M. Korach-André, C. Williams
    Scientific Reports.2020;[Epub]     CrossRef
  • 17β-Estradiol strongly inhibits azoxymethane/dextran sulfate sodium-induced colorectal cancer development in Nrf2 knockout male mice
    Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Joo Hee Son, Jeong Eun Yu, Eun Shin, Ha-Na Lee, Do-Hee Kim, Young-Joon Surh
    Biochemical Pharmacology.2020; 182: 114279.     CrossRef
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    Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos
    Disease Models & Mechanisms.2020;[Epub]     CrossRef
  • Effects of 17β-Estradiol on Colorectal Cancer Development after Azoxymethane/Dextran Sulfate Sodium Treatment of Ovariectomized Mice
    Chin-Hee Song, Nayoung Kim, Sun Min Lee, Ryoung Hee Nam, Soo In Choi, So Ra Kang, Eun Shin, Dong Ho Lee, Ha-Na Lee, Young-Joon Surh
    Biochemical Pharmacology.2019;[Epub]     CrossRef
  • 17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts
    Chin-Hee Song, Nayoung Kim, Do-Hee Kim, Ha-Na Lee, Young-Joon Surh, Seungil Ro
    PLOS ONE.2019; 14(8): e0221650.     CrossRef
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    Hee Jin Son, Nayoung Kim, Chin-Hee Song, Ryoung Hee Nam, Soo In Choi, Joo Sung Kim, Dong Ho Lee
    Journal of Cancer Prevention.2019; 24(3): 173.     CrossRef
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