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Computed Tomography–Determined Sarcopenia Is a Useful Imaging Biomarker for Predicting Postoperative Outcomes in Elderly Colorectal Cancer Patients
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Hailun Xie, Yizhen Gong, Jiaan Kuang, Ling Yan, Guotian Ruan, Shuangyi Tang, Feng Gao, Jialiang Gan
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Cancer Res Treat. 2020;52(3):957-972. Published online April 17, 2020
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DOI: https://doi.org/10.4143/crt.2019.695
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Abstract
PDFPubReaderePub
- Purpose
This study aimed to establish whether computed tomography (CT)–determined sarcopenia is a useful imaging biomarker for postoperative outcome in elderly colorectal cancer (CRC) patients, and construct sarcopenia-based nomograms to predict individual outcomes after surgery.
Materials and Methods
CT imaging data of 298 elderly CRC patients who underwent surgery in 2012-2014 were retrospectively analyzed. Skeletal muscle mass was determined by CT, and sarcopenia was diagnosed based on the optimal cutoff value determined by X-tile program. The correlation between sarcopenia and risk of preoperative nutrition and postoperative complications was evaluated. A Cox proportional hazards model was used to determine survival predictors. Sarcopenia-based nomograms were developed based on multivariate analysis, and calibrated using concordance index and calibration curves.
Results
A total 132 patients (44.3%) had sarcopenia based on the optimum cutoff values (29.9 cm2/m2 for women and 49.5 cm2/m2 for men). Sarcopenia was an independent risk factor for preoperative nutrition (p < 0.001; odds ratio [OR], 3.405; 95% confidence interval [CI], 1.948 to 5.954) and postoperative complications (p=0.008; OR, 2.192; 95% CI, 1.231 to 3.903). Sarcopenia was an independent predictor for poor progression-free survival (p < 0.001; hazard ratio [HR], 2.175; 95% CI, 1.489 to 3.179) and overall survival (p < 0.001; HR, 2.524; 95% CI, 1.721 to 3.703). Based on multivariate analysis, we produced four nomograms that had better predictive performance.
Conclusion
CT-determined sarcopenia is a useful imaging biomarker for predicting preoperative nutritional risk, postoperative complications, and long-term outcomes in elderly CRC patients. The sarcopenia-based nomograms can provide a scientific basis for guiding therapeutic schedule and follow-up strategies.
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Citations
Citations to this article as recorded by
- Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review
Shameema Farook, Saumya Soni, Arpit Shantagiri, Pankaj Gupta, Anindita Sinha, Mahesh Prakash Journal of Gastrointestinal and Abdominal Radiology.2024; 07(01): 027. CrossRef - Developing sarcopenia during neoadjuvant therapy is associated with worse survival in esophageal adenocarcinoma patients
Katherine Pierce, Prejesh Philips, Michael E Egger, Charles R Scoggins, Robert CG Martin Surgery.2024; 175(3): 718. CrossRef - PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer
Bianbian Yan, Lichao Cao, Liyang Gao, Shangqing Wei, Mengwei Wang, Ye Tian, Jin Yang, Erfei Chen Digestive Diseases and Sciences.2024; 69(1): 112. CrossRef - Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
Nerea Becerra‐Tomás, Georgios Markozannes, Margarita Cariolou, Katia Balducci, Rita Vieira, Sonia Kiss, Dagfinn Aune, Darren C. Greenwood, Laure Dossus, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried, Melissa M. Hudson, Anne M. Ma International Journal of Cancer.2024; 155(3): 400. CrossRef - Predictive role of preoperative sarcopenia for long-term survival in rectal cancer patients: A meta-analysis
Qiutong Su, Jia Shen, Zubing Mei PLOS ONE.2024; 19(5): e0303494. CrossRef - CT‐determined low skeletal muscle index predicts poor prognosis in patients with colorectal cancer
Yue Feng, Xiao‐Hong Cheng, Mei Xu, Rui Zhao, Qian‐Yi Wan, Wei‐Hua Feng, Hua‐Tian Gan Cancer Medicine.2024;[Epub] CrossRef - Serum tumor marker and CT body composition scoring system predicts outcomes in colorectal cancer surgical patients
Mingming Song, Zhihao Liu, Feihong Wu, Tong Nie, Yixin Heng, Jiaxin Xu, Ning Huang, Xiaoyu Wu, Yinghao Cao, Gang Hu European Radiology.2024; 34(12): 7596. CrossRef - The Weight of Nutrition on Post-Resection Oncologic Morbidity and Mortality: A Systematic Review and Meta-Analysis of Nutritional Indices
Katherine Pierce, Jeremy Gaskins, Robert C G Martin II Nutrition Reviews.2024;[Epub] CrossRef - Aminotransferase-to-lymphocyte ratio as a valuable prognostic marker for patients with stage I-III colorectal cancer: a retrospective study
Hailun Xie, Lishuang Wei, Shuangyi Tang, Jialiang Gan Frontiers in Oncology.2024;[Epub] CrossRef - Impact of sarcopenia on outcomes in surgical patients:A systematic review and meta-analysis
Samuel Knoedler, Rainer Schliermann, Leonard Knoedler, Mengfan Wu, Frederik J. Hansen, Dany Y. Matar, Doha Obed, Dominique Vervoort, Valentin Haug, Gabriel Hundeshagen, Angie Paik, Martin Kauke-Navarro, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adr International Journal of Surgery.2023;[Epub] CrossRef - Hand grip strength‐based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer
Hailun Xie, Guotian Ruan, Lishuang Wei, Heyang Zhang, Yizhong Ge, Qi Zhang, Shiqi Lin, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Chun‐Hua Song, Jialiang Gan, Han‐Ping Shi Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 382. CrossRef - Impact of Sarcopenia on Clinical Course of Inflammatory Bowel Disease in Korea
Kwangwoo Nam, Jae Yong Lee, Yousun Ko, Kyung Won Kim, Ho-Su Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byoun, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park Digestive Diseases and Sciences.2023; 68(6): 2165. CrossRef - Perioperative Nutritional Considerations in Colon and Rectal Surgery
Thomas Curran Clinics in Colon and Rectal Surgery.2023; 36(03): 192. CrossRef - Prognostic significance of sarcopenia diagnosed based on the anthropometric equation for progression-free survival and overall survival in patients with colorectal cancer
Hailun Xie, Lishuang Wei, Shunhui Gao, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Qiwen Wang, Yansong Xu, Shuangyi Tang, Jialiang Gan Frontiers in Nutrition.2023;[Epub] CrossRef - The prognostic value of the combination of body composition and systemic inflammation in patients with cancer cachexia
Hai‐Lun Xie, Guo‐Tian Ruan, Lishuang Wei, Qi Zhang, Yi‐Zhong Ge, Meng‐Meng Song, Xi Zhang, Shi‐qi Lin, Xiao‐yue Liu, Xiao‐Wei Zhang, Xiang‐Rui Li, Kang‐Ping Zhang, Chun‐Lei Hu, Ming Yang, Meng Tang, Chun‐Hua Song, Ming‐Hua Cong, Min Weng, Zeng‐Ning Li, We Journal of Cachexia, Sarcopenia and Muscle.2023; 14(2): 879. CrossRef - The predictive value of computerized tomography‐assessed sarcopenia for complicated appendicitis in geriatric patients
Ali Cihat Yildirim, Şahinde Atlanoğlu, Mehmet Ali Gedik, Sezgin Zeren, Mehmet Fatih Ekici AGING MEDICINE.2023; 6(3): 222. CrossRef - Improving the assessment of malnutrition in cancer: Using systemic inflammation markers as a supplement to the inflammation items of the GLIM criteria
Hailun Xie, Kaitao Yuan, Guotian Ruan, Lishuang Wei, Heyang Zhang, Yizhong Ge, Shiqi Lin, Mengmeng Song, Ziwen Wang, Chenan Liu, Jinyu Shi, Xiaoyue Liu, Ming Yang, Xin Zheng, Yue Chen, Xiaowei Zhang, Hanping Shi Clinical Nutrition.2023; 42(10): 2036. CrossRef - Computed tomography–assessed presarcopenia and clinical outcomes after laparoscopic surgery for rectal cancer
Ji Hyeong Song, Rak Kyun Oh, Jeong Eun Lee, Kyung Ha Lee, Ji Yeon Kim, Jin Soo Kim Annals of Coloproctology.2023; 39(6): 513. CrossRef - CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation
Alberto Stefano Tagliafico, Federica Rossi, Bianca Bignotti, Lorenzo Torri, Alessandro Bonsignore, Liliana Belgioia, Alida Domineitto The British Journal of Radiology.2022;[Epub] CrossRef - The Clinical Impact of Combining Neutrophil-to-Lymphocyte Ratio with Sarcopenia for Improved Discrimination of Progression-Free Survival in Patients with Colorectal Cancer
Su Young Lee, Eric Chung, Eun-Suk Cho, Jae-Hoon Lee, Eun Jung Park, Su-Jin Shin, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang Journal of Clinical Medicine.2022; 11(2): 431. CrossRef - Ability of malnutrition screening and assessment tools to identify computed tomography defined low muscle mass in colorectal cancer surgery
Aleksandra Djordjevic, Irene Deftereos, Vanessa M. Carter, Stephanie Morris, Roland Shannon, Nicole Kiss, Justin M. C. Yeung Nutrition in Clinical Practice.2022; 37(3): 666. CrossRef - Clinical Relevance of Myopenia and Myosteatosis in Colorectal Cancer
Yoshinaga Okugawa, Takahito Kitajima, Akira Yamamoto, Tadanobu Shimura, Mikio Kawamura, Takumi Fujiwara, Ikuyo Mochiki, Yoshiki Okita, Masahiro Tsujiura, Takeshi Yokoe, Masaki Ohi, Yuji Toiyama Journal of Clinical Medicine.2022; 11(9): 2617. CrossRef - Sarcopenia among older patients with cancer: A scoping review of the literature
Qian Sun, Xiaohan Jiang, Rui Qin, Yuanyuan Yang, Yabo Gong, Kunyuan Wang, Junsheng Peng Journal of Geriatric Oncology.2022; 13(7): 924. CrossRef - Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study
Hailun Xie, Guotian Ruan, Li Deng, Heyang Zhang, Yizhong Ge, Qi Zhang, Shiqi Lin, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Wen Hu, Min Weng, Hanping Shi Clinical Nutrition.2022; 41(8): 1636. CrossRef - Prognostic value of cachexia index in patients with colorectal cancer: A retrospective study
Qianyi Wan, Qian Yuan, Rui Zhao, Xiaoding Shen, Yi Chen, Tao Li, Yinghan Song Frontiers in Oncology.2022;[Epub] CrossRef - Acute Sarcopenia after Elective and Emergency Surgery
Alvin Shrestha, Melanie Dani, Paul Kemp, Michael Fertleman Aging and disease.2022; 13(6): 1759. CrossRef - Prognostic Significance of Preoperative Fibrinogen-to-Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study
Hailun Xie, Shizhen Huang, Guanghui Yuan, Shuangyi Tang, Jialiang Gan, Bing Wang BioMed Research International.2021; 2021: 1. CrossRef - Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: a systematic review and meta-analysis
Mario Trejo-Avila, Katya Bozada-Gutiérrez, Carlos Valenzuela-Salazar, Jesús Herrera-Esquivel, Mucio Moreno-Portillo International Journal of Colorectal Disease.2021; 36(6): 1077. CrossRef - Preoperative optimization and enhanced recovery for colorectal surgery
Alexander T. Booth, Thomas Curran Seminars in Colon and Rectal Surgery.2021; 32(3): 100827. CrossRef - Low CT attenuation and high fatty infiltration rate of psoas are risk factors for incisional hernias after appendicectomy: a cross-sectional single-center study from China
Xuechao Du, Pengtao Sun, Yuchang Yan, Xiang Gong, Yufei Lian, Zhenyu Pan BMC Musculoskeletal Disorders.2021;[Epub] CrossRef - Oral Nutritional Supplements and Enteral Nutrition in Patients with Gastrointestinal Surgery
Maria Wobith, Arved Weimann Nutrients.2021; 13(8): 2655. CrossRef - Preoperative computed tomography-assessed sarcopenia as a predictor of complications and long-term prognosis in patients with colorectal cancer: a systematic review and meta-analysis
Hailun Xie, Lishuang Wei, Mingxiang Liu, Guanghui Yuan, Shuangyi Tang, Jialiang Gan Langenbeck's Archives of Surgery.2021; 406(6): 1775. CrossRef - Comparison of revised EWGSOP2 criteria of sarcopenia in patients with cancer using different parameters of muscle mass
Ana Paula Trussardi Fayh, Iasmin Matias de Sousa, Stephen E. Alway PLOS ONE.2021; 16(9): e0257446. CrossRef - Impact of Computed Tomography-Based, Artificial Intelligence-Driven Volumetric Sarcopenia on Survival Outcomes in Early Cervical Cancer
Qingling Han, Se Ik Kim, Soon Ho Yoon, Taek Min Kim, Hyun-Cheol Kang, Hak Jae Kim, Jeong Yeon Cho, Jae-Weon Kim Frontiers in Oncology.2021;[Epub] CrossRef - Geriatric nutritional risk index as a predictor of complications and long-term outcomes in patients with gastrointestinal malignancy: a systematic review and meta-analysis
Hailun Xie, Shuangyi Tang, Lishuang Wei, Jialiang Gan Cancer Cell International.2020;[Epub] CrossRef
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