Cancer Research and Treatment

Giacomo Reggiori

1 Article

Hypofractionated Stereotactic Radiation Therapy in Recurrent High-Grade Glioma: A New Challenge: Pierina Navarria, Anna Maria Ascolese, Stefano Tomatis, Giacomo Reggiori, Elena Clerici, Elisa Villa, Giulia Maggi, Lorenzo Bello, Federico Pessina, Luca Cozzi, Marta Scorsetti; Cancer Res Treat. 2016;48(1):37-44. Published online February 23, 2015; DOI: https://doi.org/10.4143/crt.2014.259

Purpose
The aim of this study was to evaluate outcomes of hypofractionated-stereotactic-radiationtherapy (HSRT) in patients re-treated for recurrent high-grade glioma. Materials and Methods From January 2006 to September 2013, 25 patients were treated. Six patients underwent radiation therapy alone, while 19 underwent combined treatment with surgery and/or chemotherapy. Only patients with Karnofsky Performance Status (KPS) > 70 and time from previous radiotherapy greater than 6 months were re-irradiated. The mean recurrent tumor volume was 35 cm3 (range, 2.46 to 116.7 cm3), and most of the patients (84%) were treated with a total dose of 25 Gy in five fractions (range, 20 to 50 Gy in 5-10 fractions).
Results
The median follow-up was 18 months (range, 4 to 36 months). The progression-free survival (PFS) at 1 and 2 years was 72% and 34% and the overall survival (OS) 76% and 50%, respectively. No severe toxicity was recorded. In univariate and multivariate analysis extent of resection at diagnosis significantly influenced PFS and OS (p < 0.01). Patients with smaller recurren tumor volume treated had better local control and survival. Indeed, the 2-year PFS was 40% (≤ 50 cm3) versus 11% (p=0.1) and the 2-year OS 56% versus 33% (> 50 cm3), respectively (p=0.26). Conclusion In our experience, HSRT could be a safe and feasible therapeutic option for recurrent high grade glioma even in patients with larger tumors. We believe that a multidisciplinary evaluation is mandatory to assure the best treatment for selected patients. Local treatment should also be considered as part of an integrated approach.

Citations

Citations to this article as recorded by

Promising outcome of patients with recurrent glioblastoma after Gamma Knife-based hypofractionated radiotherapy
Mustafa Aziz Hatiboglu, Kerime Akdur, Ayten Sakarcan, Mehmet Hakan Seyithanoglu, Haci Mehmet Turk, Georges Sinclair, Mustafa Namik Oztanir
Neurochirurgie.2024; 70(2): 101532. CrossRef
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels
Wei-Min Ho, Chia-Ying Chen, Tai-Wei Chiang, Trees-Juen Chuang
Acta Neuropathologica Communications.2024;[Epub] CrossRef
Dosimetric quality of HyperArc in boost radiotherapy for single glioblastoma: comparison with CyberKnife and manual VMAT
Mingyuan Pan, Wenqian Xu, Lei Sun, Chaozhuang Wang, Shengnan Dong, Yun Guan, Jun Yang, Enmin Wang
Radiation Oncology.2023;[Epub] CrossRef
MiR-493-5p inhibits the malignant development of gliomas via suppressing E2F3-mediated dysfunctions of P53 and PI3K/AKT pathways
Hong Liu, Zhen Li, Hu Sun
Clinical and Translational Oncology.2022; 24(2): 363. CrossRef
Role of Hyperbaric Oxygenation Plus Hypofractionated Stereotactic Radiotherapy in Recurrent High-Grade Glioma
Donatella Arpa, Elisabetta Parisi, Giulia Ghigi, Annalisa Cortesi, Pasquale Longobardi, Patrizia Cenni, Martina Pieri, Luca Tontini, Elisa Neri, Simona Micheletti, Francesca Ghetti, Manuela Monti, Flavia Foca, Anna Tesei, Chiara Arienti, Anna Sarnelli, Gi
Frontiers in Oncology.2021;[Epub] CrossRef
Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis
Peng Ren, JingYa Wang, Lei Li, XiaoWan Lin, GuangHan Wu, JiaYi Chen, ZhiRui Zeng, HongMei Zhang
Bioengineered.2021; 12(1): 3188. CrossRef
Treatment Results for Recurrent Glioblastoma and Alteration of Programmed Death-Ligand 1 Expression After Recurrence
Kyoung Su Sung, Tae Hoon Roh, Ju Hyung Moon, Eui Hyun Kim, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang
World Neurosurgery.2020; 135: e459. CrossRef
Interim Tumor Progression and Volumetric Changes of Surgical Cavities during the Surgery-to-Radiotherapy Interval in Anaplastic Gliomas: Implications for Additional Pre-radiotherapy Magnetic Resonance Imaging
Chan Woo Wee, Il Han Kim, Chul-Kee Park, Jin Wook Kim
Cancer Research and Treatment.2020; 52(2): 524. CrossRef
Re-irradiation of recurrent glioblastoma using helical TomoTherapy with simultaneous integrated boost: preliminary considerations of treatment efficacy
Donatella Arpa, Elisabetta Parisi, Giulia Ghigi, Alessandro Savini, Sarah Pia Colangione, Luca Tontini, Martina Pieri, Flavia Foca, Rolando Polico, Anna Tesei, Anna Sarnelli, Antonino Romeo
Scientific Reports.2020;[Epub] CrossRef
DIFFERENTIAL DIAGNOSTICS OF A RADIONECROSIS AND LOCAL TUMORAL RECURRENCE ACCORDING TO ARTERIAL SPIN LABELLING AFTER RADIOSURGERY TREATMENT OF MALIGNANT GLIOMAS OF A BRAIN
Andrey B. Gryazov, Yulia V. Medvedovska, Andrey A. Gryazov
Wiadomości Lekarskie.2020; 73(10): 2160. CrossRef
Radiotherapy and Its Impact on the Nervous System of Cancer Survivors
Gautam Kumar, Priyadarshini Dutta, Vipan K. Parihar, Mallikarjuna R. Chamallamudi, Nitesh Kumar
CNS & Neurological Disorders - Drug Targets .2020; 19(5): 374. CrossRef
Re-irradiation for recurrent high-grade gliomas: a systematic review and analysis of treatment technique with respect to survival and risk of radionecrosis
Mihir Shanker, Benjamin Chua, Catherine Bettington, Matthew C Foote, Mark B Pinkham
Neuro-Oncology Practice.2019; 6(2): 144. CrossRef
Efficacy and Safety of Hypofractionated Stereotactic Radiotherapy for Recurrent Malignant Gliomas: A Systematic Review and Meta-analysis
Yan-jia Hu, Da Chen, Li-feng Zhang, Jing Chen
World Neurosurgery.2019; 127: 176. CrossRef
Hypofractionated stereotactic radiotherapy combined with chemotherapy or not in the management of recurrent malignant gliomas: A systematic review and meta-analysis
YJ Hu, LF Zhang, C Ding, D Chen, J Chen
Clinical Neurology and Neurosurgery.2019; 183: 105401. CrossRef
Re-irradiation in the Brain: Primary Gliomas
A.L.K. Ho, R. Jena
Clinical Oncology.2018; 30(2): 124. CrossRef
Timing of re-irradiation in recurrent high-grade gliomas: a single institution study
A. Zemlin, B. Märtens, B. Wiese, R. Merten, D. Steinmann
Journal of Neuro-Oncology.2018; 138(3): 571. CrossRef
Role of surgical resection in recurrent glioblastoma: prognostic factors and outcome evaluation in an observational study
Federico Pessina, Pierina Navarria, Luca Cozzi, Stefano Tomatis, Marco Riva, Anna Maria Ascolese, Armando Santoro, Matteo Simonelli, Lorenzo Bello, Marta Scorsetti
Journal of Neuro-Oncology.2017; 131(2): 377. CrossRef
Re-irradiation after gross total resection of recurrent glioblastoma
Christoph Straube, Greeshma Elpula, Jens Gempt, Julia Gerhardt, Stefanie Bette, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer, Stephanie E. Combs
Strahlentherapie und Onkologie.2017; 193(11): 897. CrossRef
Survival and complications of stereotactic radiosurgery
Kaleigh Fetcko, Rimas V. Lukas, Gordon A. Watson, Lingjiao Zhang, Mahua Dey
Medicine.2017; 96(43): e8293. CrossRef
Laser Ablation of Recurrent Malignant Gliomas
Analiz Rodriguez, Stephen B. Tatter
Neurosurgery.2016; 79(Supplement): S35. CrossRef

12,385 View
117 Download
19 Web of Science
20 Crossref

Author index