Cancer Research and Treatment

Eun Sook Nam

4 Articles

Calcified Carcinoma of the Gallbladder with Calcified Nodal Metastasis Presenting as a Porcelain Gallbladder: A Case Report: Eun Joo Yun, Dae Young Yoon, Chul Soon Choi, Sang Hoon Bae, Young Lan Seo, Suk Ki Chang, Kyoung Ja Lim, Jung Hye Kwon, Mi Jung Kwon, Eun Sook Nam; Cancer Res Treat. 2011;43(1):71-74. Published online March 31, 2011; DOI: https://doi.org/10.4143/crt.2011.43.1.71

Porcelain gallbladder is regarded as a risk factor of gallbladder cancer. A porcelain gallbladder with calcified regional lymph nodes was found using computed tomography (CT) and magnetic resonance imaging (MRI) in a 43-year-old man who presented with nausea, vomiting, and abdominal pain. His cholecystectomy specimen showed diffuse wall thickening and contained small gallstones. Histological examination revealed diffuse infiltrative adenocarcinoma with extensive intratumoral calcification (calcified carcinoma). The majority of the calcified material was located within or replaced the tumor glands, and was not found in the stroma. A lymph node was totally replaced with a calcified metastatic adenocarcinoma. To the best of our knowledge, only one case of calcified lymph node metastasis from a calcified carcinoma of the gallbladder has been previously reported in the literature. We herein add a case of calcified carcinoma of the gallbladder with calcified lymph node metastasis, presenting as a porcelain gallbladder on CT and MRI.

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A porcelain gallbladder and a rapid tumor dissemination
Juan-Ramón Gómez-López, Beatriz De Andrés-Asenjo, Christian Ortega-Loubon
Annals of Medicine and Surgery.2014; 3(4): 119. CrossRef
Porcelain Gallbladder: A Benign Process or Concern for Malignancy?
Thomas Schnelldorfer
Journal of Gastrointestinal Surgery.2013; 17(6): 1161. CrossRef

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Expression of Maspin is associated with the Intestinal Type of Gastric Adenocarcinoma: Seong Man Kim, Seong Jin Cho, Woo Young Jang, Duck Hwan Kim, Hyung Sik Shin, Myoung Kuk Jang, Hak Yang Kim, Eun Sook Nam; Cancer Res Treat. 2005;37(4):228-232. Published online August 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.4.228

Abstract PDF PubReader ePub

Purpose

Maspin is known as a tumor suppressor gene, but its significance has been questioned in various human cancers. The aim of this study was to investigate the expression pattern of Maspin in human gastric adenocarcinomas and its possible correlation with clinicopathological findings.

Materials and Methods

The expression of Maspin mRNA was measured by nested RT-PCR using 60 frozen adenocarcinomas of the stomach and 31 noncancerous tissues from the proximal resection margin. Immunohistochemical study for Maspin protein expression was carried out using 62 paraffin-embedded tissues, composed of both cancer and noncancerous tissues.

Results

Maspin mRNA expression was detected in 80.0% (48 of 60) of the gastric adenocarcinomas, but in only 22.6% (7 of 31) of the normal gastric mucosa (p<0.001). The positive rate of Maspin protein expression was higher in the adenocarcinomas than the normal tissues (62.9% vs. 27.4%, p<0.05). In addition, the intestinal type of tumors showed significantly higher expression levels compared to the diffuse type of tumors (81.5% vs. 48.6%, p<0.05).

Conclusion

Our results suggest that Maspin is frequently expressed in human gastric cancers, and its expression might be associated with tumorigenesis of the intestinal type of gastric cancer.

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P176S Mutation Rewires Electrostatic Interactions That Alter Maspin Functionality
Muhammad Ayaz Anwar, Muhammad Haseeb, Sangdun Choi, Kwang Pyo Kim
ACS Omega.2023; 8(31): 28258. CrossRef
SERPINB5 is a novel serum diagnostic biomarker for gastric high-grade intraepithelial neoplasia and plays a role in regulation of macrophage phenotypes
Xiuhong Huang, Xiaoli Xie, Ning Kang, Ran Qi, Xue Zhou, Yijun Wang, Huiqing Jiang
Translational Oncology.2023; 37: 101757. CrossRef
Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer
Zhiyong Lai, Yang Yang, Yichao Yan, Tao Li, Yansen Li, Zhu Wang, Zhanlong Shen, Yingjiang Ye, Kewei Jiang, Shan Wang
Cell Cycle.2017; 16(23): 2301. CrossRef
The roles of maspin expression in gastric cancer: a meta- and bioinformatics analysis
Hua-Chuan Zheng, Bao-Cheng Gong
Oncotarget.2017; 8(39): 66476. CrossRef
Maspin: molecular mechanisms and therapeutic implications
Thomas M. Bodenstine, Richard E. B. Seftor, Zhila Khalkhali-Ellis, Elisabeth A. Seftor, Philip A. Pemberton, Mary J. C. Hendrix
Cancer and Metastasis Reviews.2012; 31(3-4): 529. CrossRef
Prognostic value of nuclear maspin expression for adjuvant 5-fluorouracil-based chemotherapy in advanced gastric cancer
KE-FENG LEI, BING-YA LIU, XIAO-LONG JIN, YAN GUO, MIN YE, ZHENG-GANG ZHU
Experimental and Therapeutic Medicine.2012; 3(6): 993. CrossRef

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Correlation of Mast Cell Densities, Angiogenesis and Vascular Endothelial Growth Factor in Proper Muscle Gastric Carcinomas: Eun Sook Nam, Duck Hwan Kim, Gi Taek Jang, Hae Rim Park, Jeong Rye Kim, Hyung Sik Shin; Cancer Res Treat. 2002;34(1):41-45. Published online February 28, 2002; DOI: https://doi.org/10.4143/crt.2002.34.1.41

Abstract PDF

PURPOSE
There are increasing evidences that angiogenesis enhances tumor growth and biological aggressiveness in gastric carcinoma. Mast cells have been implicated in the angiogenic process, by secreting angiogenic factors including vascular endothelial growth factor (VEGF), or enzymes that degrade extracellular matrices. However, the exact nature of mast cells in relation to cancer is contradictory so we conducted retrospective studies, to find the significance of mast cell densities, and microvessel counts in each clinicopathologic factors, including VEGF expression, in proper muscle (PM) gastric carcinoma.
MATERIALS AND METHODS
52 specimens, obtained from patients with PM gastric carcinoma, were studied using the immunohistochemical methods, monoclonal antibodies for mast cell tryptase, factor VIII-related antigen and VEGF.
RESULTS
Mast cell densities were significantly increased in diffuse histologic type (p=0.042), infiltrating margins (p<0.0001) and VEGF positive (p=0.010) tumors.Microvessel counts were significantly higher in patients over 55 years old (p=0.024), with tumor sizes larger than >3 cm (p=0.015), diffuse histologic type (p=0.038) and lymph node metastasis (p=0.001). Similarly there were significantly increased densities in VEGF positive tumors (p<0.0001). Pearson's correlation analysis revealed a significant relationship between mast cell densities and microvessel counts (r=0.614, p<0.01), indicating a high vascular grade with increased number of mast cells.
CONCLUSION
We demonstrated a close relationship between mast cell densities, microvessel counts and VEGF expression. These results suggest that mast cells and VEGF are important regulators of tumor angiogenesis and cooperatively induce the formation of vascular stroma in PM gastric carcinomas.

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Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery
Michele Ammendola, Rosario Sacco, Valeria Zuccalà, Maria Luposella, Rosa Patruno, Pietro Gadaleta, Nicola Zizzo, Cosmo Gadaleta, Giovambattista De Sarro, Giuseppe Sammarco, Mihai Oltean, Girolamo Ranieri
International Journal of Molecular Sciences.2016; 17(11): 1905. CrossRef

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Expression of High Mobility Group Protein Family [HMGI(Y) and HMGI-C] in Human Breast Cancer: Jin Woo Ryu, Duck Hwan Kim, Hyung Sik Shin, Eun Sook Nam, Hyung Jee Kim; Cancer Res Treat. 2001;33(4):281-285. Published online August 31, 2001; DOI: https://doi.org/10.4143/crt.2001.33.4.281

Abstract PDF

PURPOSE
Breast cancer results from the progressive accumulation of a series of genetic alterations leading to neoplastic transformation. Recent studies have shown that a) HMGI proteins play an important role in the regulation of chromatin structure and function and b) the expression of aberrant HMGI [HMGI(Y) and HMGI-C] proteins is generally correlated with malignant tumors. We tried to define the function of HMGI in carcinogenesis and we compare the expression of HMGI with known clinicopathologic parameters.
MATERIALS AND METHODS
Using Reverse transcriptase-polymerase chain reaction (RT-PCR), we determined the expression of HMGI mRNA in 60 primary malignant tumors, 20 normal tissue, 13 benign tumors, and four ductal carcinoma in situ. Immunohistochemical staining of p53, ER, PR, and clinicopathological parameters were evaluated.
RESULTS
The expression of the HMGI(Y) mRNA increased more in malignant tissue (90%, 54 of 60) than in benign (76.9%) and normal (65%) tissues (p=0.031). The expression of HMGI-C mRNA was visible only in malignant (48.4%, 29 of 60) and benign (23.1%, 3 of 13) tumors. The expression of HMGI-C mRNA increased more in malignant tumors than in benign tumors (p<0.001). In invasive ductal tumors (n=50), the expression of HMGI-C mRNA was observed more in high grade tumors (grade 3~81.3%, grade 1, 2~32.4%) (p=0.005). Among the prognostic parameters, only the number of mitotic figures was related to the expression of HMGI-C mRNA (p=0.046).
CONCLUSION
These results suggest that a) HMGI-C gene may be correlated with the formation of breast tumors and b) the expression of HMGI-C gene may be of pathogenetic and prognostic importance in human breast cancer.

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Cytoplasmic levels of high mobility group A2 determine survival prognoses in breast cancer patients
Thorsten Heilmann, Florian Vondung, Christoph Borzikowsky, Sandra Krüger, Mohamed Elessawy, Ibrahim Alkatout, Antonia Wenners, Maret Bauer, Wolfram Klapper, Christoph Röcken, Nicolai Maass, Christian Schem, Anna Trauzold
The International Journal of Biological Markers.2020; 35(2): 20. CrossRef
High Mobility Group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression
Riccardo Sgarra, Silvia Pegoraro, Gloria Ros, Carlotta Penzo, Eusebio Chiefari, Daniela Foti, Antonio Brunetti, Guidalberto Manfioletti
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2018; 1869(2): 216. CrossRef

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