Cancer Research and Treatment

Dong Young Noh

36 Articles

The Relationship between Expression of the Sodium/iodide Symporter Gene and the Status of Hormonal Receptors in Human Breast Cancer Tissue: Hyun Jung Oh, June-Key Chung, Joo Hyun Kang, Won Jun Kang, Dong Young Noh, In Ae Park, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee; Cancer Res Treat. 2005;37(4):247-250. Published online August 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.4.247

Purpose

It has been reported that the sodium/iodide symporter (NIS) gene is expressed in several breast cancer tissues, suggesting the possibility of radionuclide imaging and therapy. However, the regulatory mechanism of NIS gene expression in breast cancer is not yet understood. To assess the relationship between the hormonal status and the NIS expression in breast cancer tissue, we investigated the NIS expression and correlated it to the expression of the thyrotropin receptor (thyroid stimulating hormone receptor, TSH-R), the estrogen receptor (ER) and the progesterone receptor (PR) in human breast cancer tissues.

Materials and Methods

Breast cancer tissues were obtained from 44 patients. Pathological examination showed 2 cases of Grade I, 17 of Grade II, 22 of Grade III, and 3 of unknown grade. We measured the expression of NIS and TSH-R genes by using RT-PCR and we measured the status of ER and PR by using immunohistochemistry.

Results

The NIS gene was expressed in 15 (34%) of the 44 breast cancer tissues. The NIS gene was expressed in 32% of the cases with TSH-R gene expression. The NIS gene was expressed in 40% of the breast cancer tissues with a positive PR and in 31% with a negative PR (p>0.05). It was positive for PR in 18% of the cases and negative for PR in 39% of the cases (p>0.05).

Conclusion

The NIS gene is expressed in approximately one-third of the human breast cancer tissues. Its expression was not related to the presence of the TSH-R gene or hormonal receptors, ER and PR.

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Benign thyroid disease and the risk of breast cancer: An updated systematic review and meta-analysis
Mingyue Han, Yao Wang, Yuanhui Jin, Xue Zhao, Haiying Cui, Guixia Wang, Xiaokun Gang
Frontiers in Endocrinology.2022;[Epub] CrossRef
Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions
Man Lu, Hanqing Liu, Bilian Zheng, Shengrong Sun, Chuang Chen
Cancers.2022; 14(20): 5117. CrossRef
Competitive Endogenous Role of the LINC00511/miR-185-3p Axis and miR-301a-3p From Liquid Biopsy as Molecular Markers for Breast Cancer Diagnosis
Marwa M. Mahmoud, Eman F. Sanad, Reham A.A. Elshimy, Nadia M. Hamdy
Frontiers in Oncology.2021;[Epub] CrossRef
The correlation between breast cancer and urinary iodine excretion levels
Fatma Umit Malya, Huseyin Kadioglu, Mustafa Hasbahceci, Kemal Dolay, Mehmet Guzel, Yeliz Emine Ersoy
Journal of International Medical Research.2018; 46(2): 687. CrossRef
Different expression of sodium–iodide importer (NIS) between lactating breast and thyroid tissues may be due to structural difference of thyroid-stimulating hormone receptor (TSHR)
X.-Z. Shi, L. Xue, X. Jin, P. Xu, S. Jia, H.-M. Shen
Journal of Endocrinological Investigation.2017; 40(1): 41. CrossRef
Is there an association between thyroid function abnormalities and breast cancer?
Anna Angelousi, Evanthia Diamanti-Kandarakis, Evangelia Zapanti, Afroditi Nonni, Eftuxios Ktenas, Aimilia Mantzou, Konstantinos Kontzoglou, Grigorios Kouraklis
Archives of Endocrinology and Metabolism.2017; 61(1): 54. CrossRef
Iodide transport and breast cancer
Vikki L Poole, Christopher J McCabe
Journal of Endocrinology.2015; 227(1): R1. CrossRef
The prognosis and treatment of primary thyroid cancer occurred in breast cancer patients: comparison with ordinary thyroid cancer
Chang Min Park, Young Don Lee, Eun Mee Oh, Kwan-Il Kim, Heung Kyu Park, Kwang-Pil Ko, Yoo Seung Chung
Annals of Surgical Treatment and Research.2014; 86(4): 169. CrossRef
Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer
Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti, Diego Russo
BMC Cancer.2014;[Epub] CrossRef
TSH receptor antibodies have predictive value for breast cancer – retrospective analysis
Paweł Szychta, Wojciech Szychta, Adam Gesing, Andrzej Lewiński, Małgorzata Karbownik-Lewińska
Thyroid Research.2013;[Epub] CrossRef
Quantitative Immunohistochemical Analysis Reveals Association between Sodium Iodide Symporter and Estrogen Receptor Expression in Breast Cancer
Sushmita Chatterjee, Renu Malhotra, Frency Varghese, Amirali B. Bukhari, Asawari Patil, Ashwini Budrukkar, Vani Parmar, Sudeep Gupta, Abhijit De, Pranela Rameshwar
PLoS ONE.2013; 8(1): e54055. CrossRef
Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer
Sasha J Beyer, Xiaoli Zhang, Rafael E Jimenez, Mei-Ling T Lee, Andrea L Richardson, Kun Huang, Sissy M Jhiang
BMC Research Notes.2011;[Epub] CrossRef
Do cell surface trafficking impairments account for variable cell surface sodium iodide symporter levels in breast cancer?
S. J. Beyer, R. E. Jimenez, C. L. Shapiro, J. Y. Cho, S. M. Jhiang
Breast Cancer Research and Treatment.2009; 115(1): 205. CrossRef

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The Estimation of Breast Cancer Disease-Probability by Difference of Individual Susceptibility: Sue Kyung Park, Keun Young Yoo, Dae Hee Kang, Sei Hyun Ahn, Dong Young Noh, Kuk Jin Choe; Cancer Res Treat. 2003;35(1):35-51. Published online February 28, 2003; DOI: https://doi.org/10.4143/crt.2003.35.1.35

Abstract PDF

PURPOSE
The aims were to evaluate the main risk factors (RFs) of breast cancer and to estimate the individual disease-probability from combinations of RFs in Korean female. MATERIALS AND METHODS: We conducted case-control study of 1, 687 incident cases of invasive carcinoma and 1, 238 controls during 1996~2000. A breast cancer disease-probability model was established by a general modeling process using a multivariate logistic regression model, which included the main Korean RFs and synergistic interaction-terms. RESULTS: The main Korean RFs selected were age, family history of second relatives, BMI, age at first full term pregnancy, breast-feeding, and a special test on the breasts. Two synergisms were observed between age and breast-feeding, and between special test and age at first fullterm pregnancy. The disease-probability and model are shown in Table 4, and Appendix 1. CONCLUSION: The availability of previous Western models was limited for Korean female due to the differences inhazard-rates and the characteristics of breast cancer between Asian and Western females. Due to limited basic data, i.e. incidence, hazard-rate and cancer-cohorts, the developing-probability of breast cancer for Korean females was not calculated. Therefore, the disease-probability was calculated instead. This approach might be more beneficial for Koreans, and help in the decision- making for regular screening or hospital visit-interval, counseling in breast-cancer clinics, prescribing high-risk population, and in educating for primary prevention, although it over-estimates the relative probability compared to the developing-probability and the 65% predictive validity.

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Validating Breast Cancer Risk Prediction Models in the Korean Cancer Prevention Study-II Biobank
Yon Ho Jee, Chi Gao, Jihye Kim, Seho Park, Sun Ha Jee, Peter Kraft
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(6): 1271. CrossRef
Bone mineral density and the risk of breast cancer: a case-control study of Korean women
Bo-Kyoung Kim, Yoon-Ho Choi, Yun-Mi Song, Joo-Hyun Park, Hye-Mi Noh, Tuong L. Nguyen, John L. Hopper
Annals of Epidemiology.2014; 24(3): 222. CrossRef
Breast cancer screening rates-related factors Korea women ever considering area environmental characteristics: The fourth Korea National Health and Nutrition Examination Survey(KNHANES IV)
Mi-Hwa Lee, Sang-Hyun Kim
Journal of Digital Convergence.2014; 12(11): 437. CrossRef
Validation of Risk Assessment Models for Predicting the Incidence of Breast Cancer in Korean Women
Jun Won Min, Myung-Chul Chang, Hae Kyung Lee, Min Hee Hur, Dong-Young Noh, Jung Han Yoon, Yongsik Jung, Jung-Hyun Yang
Journal of Breast Cancer.2014; 17(3): 226. CrossRef
Estimated risks and optimistic self-perception of breast cancer risk in Korean women
ChaeWeon Chung, Suk Jeong Lee
Applied Nursing Research.2013; 26(4): 180. CrossRef
Korean Risk Assessment Model for Breast Cancer Risk Prediction
Boyoung Park, Seung Hyun Ma, Aesun Shin, Myung-Chul Chang, Ji-Yeob Choi, Sungwan Kim, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Daehee Kang, Keun-Young Yoo, Sue K. Park, Todd W. Miller
PLoS ONE.2013; 8(10): e76736. CrossRef
The proper approaches for breast disease
Jihoon Yu, Intaek Hwang
Korean Journal of Obstetrics.2011; 54(2): 67. CrossRef
Factors Affecting Periodic Screening Behaviors for Breast Cancer among Hospital Nurses
Suk Ok Lee, Eun Soon Sim, Sukhee Ahn
Korean Journal of Women Health Nursing.2010; 16(4): 390. CrossRef
Epidemiologic Characteristics of the Breast Cancer in Korea
Sue K Park, Daehee Kang, Yeonju Kim, Keun-Young Yoo
Journal of the Korean Medical Association.2009; 52(10): 937. CrossRef
Implications of Systematic Review for Breast Cancer Prediction
Sun-Mi Lee, Jin-Hee Park, Han-Jong Park
Cancer Nursing.2008; 31(5): E40. CrossRef
Breast cancer risk factors in Korean women: a literature review
S.‐M. Lee, J.‐H. Park, H.‐J. Park
International Nursing Review.2008; 55(3): 355. CrossRef
The Loss of P16ink4Expression is Strongly Associated with Hypermethylation-Related Inactivation in Breast Carcinoma
Gyungyub Gong, Mi-Jung Kim, Yhong-Hee Shim, Gyeong Hoon Kang, Sei Hyun Ahn, Jae Y. Ro
Journal of Breast Cancer.2006; 9(2): 84. CrossRef
Epidemiology and Risk Factors of Breast Cancer
Keun-Young Yoo
Journal of the Korean Medical Association.2003; 46(6): 482. CrossRef

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Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk: Sook Un Kim, Kyoung Mu Lee, Sue Kyung Park, Keun Young Yoo, Dong Young Noh, Kook Jin Choe, Se Hyun Ahn, Daehee Kang; Cancer Res Treat. 2002;34(3):205-211. Published online June 30, 2002; DOI: https://doi.org/10.4143/crt.2002.34.3.205

Abstract PDF

PURPOSE
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.
RESULTS
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).
CONCLUSION
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.

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Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea
Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass
BMC Cancer.2014;[Epub] CrossRef

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Correlation of GLUT-1 Expression and F-18-FDG Uptake on Positron Emission Tomography in Breast Carcinoma: Gi Jeong Cheon, June Key Chung, Bo Kwang Kim, Yong Jin Lee, Dong Young Noh, Ja June Jang, Jeong Seok Yeo, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee; J Korean Cancer Assoc. 2000;32(6):1067-1074.

Abstract PDF: PURPOSE
Fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) has been proven to be useful in the detection of breast cancer. However, the degree of FDG uptake was variable. In this study, we evaluated the relationship between glucose transporter-1 (GLUT-1) expression with the FDG uptake in patients with breast cancer.
MATERIALS AND METHODS
15 patients with proven breast cancer underwent F-18-FDG PET. After surgical resection, anti-GLUT-1 immunohistochemical staining was performed in tumor tissues to measure the GLUT-1 expression. We evaluated the correlation between semi-quantitative FDG uptake by standardized uptake value (SUV) and GLUT-1 expression.
RESULTS
In total 15 patients, there was no significant correlation between SUV and GLUT-1 expression. We separated the patients into two groups according to the tumor size. In the group of large tumor (short diameter > or =2 cm), there was no significant correlation. However, in the group of small tumor (short diameter <2 cm), there was a significant correlation between the FDG uptake and GLUT-1 expression (rho=0.812, p=0.047).
CONCLUSION
GLUT-1 expression can influence the FDG uptake in the small breast cancers. For large breast cancers, other factors as well as GLUT-1 expression may influence the FDG uptake.

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The Role of bcl-2 and p53 in Tamoxifen-Induced Apoptosis of Human Breast Cancer Cell Lines: Woo Chul Noh, Dong Young Noh, Yong Ho Ham, Chang Min Kim, Nam Sun Paik, Nan Mo Moon, Kuk Jin Choe; J Korean Cancer Assoc. 2000;32(3):531-538.

Abstract PDF: PURPOSE
Tamoxifen has been well known as an effective anti-tumor agent against breast cancer. The important role of bcl-2 and p53 proteins in tamoxifen-induced apoptosis of breast cancer cells has been suggested. However, the paradoxical fact that bcl-2 over-expression is assdegrees Ciated with better prognosis in clinic has not yet been clearly explained. To investigate this paradox, we analyzed the effect and dynamics of bcl-2 and p53 on the apoptosis after treatment of breast cancer cells with tamoxifen.
MATERIALS AND METHODS
The human breast cancer cell lines MCF-7 and MB MDA-468 were treated with 17-betaestradiol (E2) and tamoxifen.
RESULTS
Following tamoxifen treatment, MCF-7 cells underwent apoptosis accompanied by reduced bcl-2 expression. E2 pre-treatment led to the inhibition of tamoxifen-mediated apoptosis and bcl-2 down-regulation. When MB MDA-468 cells were treated with E2 or tamoxifen, bcl-2 and p53 protein expression did not change and apoptosis did not develop.
CONCLUSION
We observed that the down-regulation of bcl-2 by tamoxifen treatment can facilitate the apoptosis of breast cancer cells without p53 mutations. This finding was consistent with clinical experiences in which bcl-2 positive tumors were assdegrees Ciated with more indolent phenotypes in breast cancer.

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The Predictors of Axillary Node Metastasis in 2 cm or Less Breast Cancer: Han Sung Kang, Dong Young Noh, Oh Joong Kwon, Yeo Kyu Youn, Seung Keun Oh, Kuk Jin Choe; J Korean Cancer Assoc. 1999;31(6):1188-1194.

Abstract PDF: PURPOSE
Axillary node involvement is the single most important prognostic variable in patients with breast cancer. If axillary lymph node status of breast cancer patients could be accurately predicted from basic clinical information and from characteristics of their primary tumors, many patients could be spared axillary lymph node dissection. With the availability of numerous histologic prognosticators and new immunochemical prognostic indicators, it is reasonable to reconsider the necessity of axillary node dissection for lesions more advanced than duct carcinoma in situ.
MATERIALS AND METHODS
Six hundred fifty-six patients with Tl invasive breast cancer were evaluated. All the patients underwent axillary dissection, and the pathologic status of the nodes was known. The parameters of the primary tumor in this study were age, size, family history, tumor palpability, nuclear and histological grade, hormone receptor status, lymphatic vessel invasion (LVI), and various tumor markers (bc1-2, cathepsinD, c-erbB2, E-cadherin, p53).
RESULTS
Approximately 31% of the 656 patients with Tl breast carcinoma had axillary node metastasis. Four factors were identified as significant predictors of node metastasis: age 35 or less (p=0.01), lymphatic vessel invasion (p < 0.01), tumor palpability (p=0.02), and tumor size (p<0.01). However, independent predictors of lymph node metastasis in the multivariate logistic regression analyses were tumor size (p=0.04) and LVI (p=0.03).
CONCLUSION
Characteristics of the primary tumor can help assess the risk for axillary lymph node metastases in Tl breast cancer. Selected patients who have 1cm or less without lymphatic vessel invasion are considered to be at minimal risk of axillary node metastasis and might be spared routine axillary dissection.

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Clinical Analysis of Malignant Pheochromocytoma: Seung Eun Choi, Young Cheol Kim, Tae Seon Kim, Dong Young Noh, Yeo Kyu Youn, Kuk Jin Choe, Seung Keun Oh; J Korean Cancer Assoc. 1999;31(6):1307-1314.

Abstract PDF: PURPOSE
There are no specific clinical and histopathologic characteristics of malignant pheochromocytoma and the optimal treatment modality has not been established yet. We analyzed the clinical and histopathologic features of malignant pheochromocytoma and treatment results.
MATERIALS AND METHODS
We reviewed the clinical records of 10 patients with malignant pheochromocytoma diagnosed at Seoul National University Hospital from March 1987 to June 1998.
RESULTS
Nine of 10 (90%) patients had functional tumors. The biochemical laboratory findings showed elevated 24-hour urine VMA level in nine patients available. The median size of the tumors was 11x11 cm. Six of 10 (60%) patients were initially diagnosed as malignant tumors because of direct invasions to adjacent tissues or distant metastases. On the other hand, remaining 4 patients were initially diagnosed as benign, but the distant metastases developed metachronously after resection of the primary lesion. The median duration between the initial operation and the detection of metastases was 57 months (range: 47~72 months) in these patients. The liver was the most common site of metastases (60%). With regards to the histopathological features, most of the tumors (87.5%) showed capsulation, necrosis and hemorrhage. The findings of lymphatic invasion, angio-invasion, and mitosis were found in 62.5% of the cases. All but 2 patients were initially treated with radical operation for the primary lesions. The disease recurrences or metastases occurred in 7 out of 10 patients. Of these, 4 patients were treated with chemotherapy or interferon- a after recurrences. Overall, the median survival for all patients was 82 months (range: 37~143 months). Two patients is alive and only one patient is alive without recurrence.
CONCLUSION
The careful follow-up for at least 5 years and the aggressive multi-disciplinary therapy may be needed for the diagnosis and the management of malignant pheochromocytoma.

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A Case-Control Study of the Association between Glutathione S-transferase (GST) M1 and T1 Genetic Polymorphism and Breast Cancer in Korean Women: Preliminary report: Sue Kyung Park, Dae Hee Kang, Byung Joo Park, Seung Joon Lee, Young Chul Kim, Han Sung Kang, Jun Suk Suh, Se Hyun Ahn, Dong Young Noh, Kuk Jin Choe; J Korean Cancer Assoc. 1999;31(4):653-662.

Abstract PDF: PURPOSE
A hospital-based case-control study was conducted to evaluate the role of glutathione-S-transferase (GST) Ml and Tl genetic polymorphism for developing breast cancer in Korea.
MATERIALS AND METHODS
Histologically confirmed incident cases of breast cancer (n=176) were selected from inpatients at the Department of General Surgery, Seoul National University Hospital (SNUH), Borame hospital, and Asan Medical Center from 1994 to 1998. Women with no self-reporting past history of any malignancies who were selected from the inpatients at the same department at three hospitals during the same period served as controls (n 118). Information on the life-styles including reproductive factors were obtained by interview using questionnaire. Age and education adjusted odds ratio and 95% confidence interval were estimated by unconditional linear logistic regression.
RESULTS
These subjects had similar risk factors for developing breast cancer to general Korean population based on other epidetniologic studies previously performed in Korea. GSTI1 null type showed a borderline significance relation in the breast cancer risk (adjusted OR=1.6, 95% CI=0.96-2.62), however, GSTM1 null type was not significant (adjusted OR=1.1, 95% CI=0.67-1.80). Particularly noteworthy was an borderline increasing tendency (p<0.1) of the breast cancer risk with the risk null genotypes assessed by multivariate logistic regression model after adjusting age and education: the putative low-risk genotype with both GSTM1 & GSTT1 wild type, OR=1.0; one putative high risk genotype with GSTM1 null or GSTMl null type, OR=1.9 (95% CI=0.92-3.74); all two putative high risk genotype with both GSTM1 & GSTT1 null type, OR=2.0 (95% CI=0.89-4.68).
CONCLUSIONS
These findings suggest that both GSTMl and GSTT1 null type might be the risk factor of developing breast cancer in Korean women. Further investigation with larger sample size should be needed to provide more concrete information on the role of GST genetic polymorphism in breast cancer.

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A Clinical Study of Infiltrating Lobular Breast Cancer: Jung Mo Kim, Young Chul Kim, Dong Young Noh, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe; J Korean Cancer Assoc. 1999;31(1):90-97.

Abstract PDF: PURPOSE
Infiltrating lobular carcinoma of the breast was known to have a high incidence of multicentricity and bilaterality in patients. We analyzed the clinical features of infiltrating lobular breast cancer.
MATERIALS AND METHODS
We studied 29 patients with infiltrating lobular carcinoma of the breast, from Jan. 1980 to Mar. 1997 in the Department of Surgery, Seoul National University Hospital.
RESULTS
The age of the patients ranged from 32 to 71 years with an average of 45.2 years. The main complaining symptom was a painless mass. The diameter of the tumor ranged from 0.7 to 7 cm with a mean size of 2.8 cm. The axillary lymph node was positive for malignancy in 12 cases. The number of multicentric breast cancers were 7 cases (24.1%), and the number of bilateral breast cancers were 3 cases (10.3%). The estrogen receptor was positive in 66.7%, and the progesterone receptor was positive in 75% of the cases. There were one local recurrence and three distant metastases during a mean follow-up period of 4.5 years. The 5-year survival rate and 5-year disease free survival rate were 89.6% and 88.6%, respectively.
CONCLUSION
Infiltrating lobular breast cancers are at greater risk of developing multicentricity and bilaterality than nonlobular breast cancers. Careful program of frequent follow-up examinations and thorough histopathological studies are needed for patients with infiltrating lobular breast cancers.

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The Expression of Phospholipase C-gamma1 and Its Cellular Characteristics: Dong Young Noh, Han Sung Kang, Young Chul Kim, In Ae Park, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe; J Korean Cancer Assoc. 1998;30(3):457-463.

Abstract PDF: BACKGROUND
The activation of phospholipase C(PLC) is one of the early cellular events in various growth process, including malignant transformation. PLC-gamma1 is activated through direct interaction with growth factor receptor tyrosine kinase. MATERIAL AND METHODS: Using immunoblot assay, we evaluated overexpression of PLC-gamma1 expression in twenty human breast cancer tissues. It was also determined whether there was any connection between other prognostic factors(numbers of metastatic axillary nodes, nuclear and histological grade, c-erbB2, p53 and E-cadherin) and the overexpression of PLC-gamma1 protein.
RESULTS
Seventeen of 20 breast cancer tissues showed overexpression of PLC-gamma1, which was corresponded to that seen on the immunohistochemistry( kappa= 0.8275, p = 0.003). Of 3 tumor markers, immunohistochemically determined, positive expression of E-cadherin only was associated with PLC-gamma1 protein overexpression in a range of statistical significance (p=0.045, kappa=0.607).
CONCLUSION
PLC-gamma1 overexpression might be pathogenic trigger involved in breast cancer and the relationship between expression of E-cadherin and PLC-gamma1 would require further elucidation.

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High Risk Group for Female Breast Cancer in Korea: Keun Young Yoo, Sue Kyung Park, Joohun Sung, Daehee Kang, Young Cheol Kim, Han Sung Kang, Jun Suk Suh, Jee Soo Kim, Ik Jin Yun, Sehwan Han, Dong Young Noh, Kyk Jin Choe; J Korean Cancer Assoc. 1998;30(3):435-449.

Abstract PDF: PURPOSE
A hospital-based case-control study was conducted to find out risk factors for developing breast cancer in Korea.
MATERIALS AND METHODS
Histologically confirmed incident cases of breast cancer(n=280) were selected from inpatients at the Department of General Surgery, Seoul National University Hospital during 1994 to 1997. Women with free of self-reporting past history of any malignancies were regarded as controls who were selected from the inpatients at the Department of Obstetrics and Gynecology of the same hospital during 1992 to 1994(n=930). Information on life-styles including reproductive factors were obtained by direct interview using questionnaire. Age- and education-adjusted odds ratio and 95% confidence interval were estimated by unconditional linear logistic regression.
RESULTS
Based on the risk factors identified by both this study and other epidemiologic studies previously performed in Korea, high risk group for female breast cancer in Korea was established as follows. (1) women with age over 50, (2) women who have a family history of breast cancer, (3) women with age at menarche before 14-year old, (4) women with age at menopause after 50-year old, (5) women who were not experienced a full term pregnancy, (5) nulliparous women (6) women with age at her first fullterm pregnancy after 35-year old (7) women who were not experienced breast feeding, (8) women with body mass index more than 25 kg/m2 or with body weight more than 64 kg.
CONCLUSION
Life-time risk of breast cancer, as an indicator of absolute risk, according to the risk factors should be pursued in further prospective studies with community population.

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Breast Cancer of 35 Years Old or Less: Han Sung Kang, Han Kwang Yang, Dong Young Noh, Yeo Kyu Yong, Sang Joon Kim, Seung Keun Oh, Kuk Jin Choe, Jin Pok Kim; J Korean Cancer Assoc. 1998;30(2):262-271.

Abstract PDF: PURPOSE
The age of onset of Korean breast carcinoma is younger than that in western countries by some 10 years, thus the criteria of young age in manuscript from western countries cannot reflect the characteristics of young breast cancer properly in Korea.
MATERIALS AND METHODS
We studied 290 breast cancer patients, 35 years old or younger retrospectively, from Jan. 1980 to Dec. 1995 in the Department of Surgery, Seoul National University Hospital. The age criteria of 30 and 35 years was utilized to define two groups.
RESULTS
The group(age< or =35) had larger primary tumors, more metastatic lymph nodes, and worse stages than older counterpart(p=0.015, 0.0066, 0.0329 respectively). They had worse disease-free survival but not overall survival(p=0.0312, 0.2427 respectively). The other group(age < or =30) showed significantly worse outcome in overall as well as disease free survival(p=0.0056, 0.0013) compared to the group(age>30). When we compared the group of age< or =30 to that of 31< or = age < or =35, there was statistically significant difference in primary tumor size, axillary nodal status and pathological stage(p=0.023, 0.019, 0.022 respectively).
CONCLUSION
The age of 30 might be better criteria to define young age as prognostic factor rather than age of 35 in Korea.

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Retroperitoneal Sarcoma: Ji Soo Kim, Won Shik Han, Dong Young Noh, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe; J Korean Cancer Assoc. 1998;30(2):370-377.

Abstract PDF: PURPOSE
To determine the clinical feature, surgical management of primary and recurrent disease, predictive factors for outcome, and impact of multimodality therapy in retroperitoneal sarcoma.
MATERIALS AND METHODS
60 patients were confirmed pathologically as soft-tissue sarcoma of the retroperitoneum by operation or needle biopsy in Seoul National University Hospital from 1983 to 1995. A retrospective analysis was performed.
RESULTS
The abdominal mass was common presenting symptom. Histologically liposarcomas(25%) and leiomyosarcomas(23.3%) were most common, and MFHs(11.7%) and malignant schwannomas(11.7%) followed. The overall 5 year survival rate was 54.6%. Complete resection was possible in 51.7% of patients and strongly predicts outcome (<0.0001). These patients had a median survival of 130 months compared to 20 months for those undergoing partial resection and 9 months for those with unresectable tumors. 11(35%) of completely resected patients have had local recurrence. These patients underwent reoperation when feasible. Complete resection of recurrent disease was performed in 10 patients(90%), with a 42 months median survival time after reoperation. Resection of adjacent organ was performed in 19 patients. 14 of these were completely resected, and showed 100% of 5 year survival rate. Tumor grade was not a significant predictor of outcome. Gender, histologic type, encapsulation, stage, resectability, combined resection were significant prognostic factors by univariate analysis. But resectability was only independent prognostic factor on mutivariate analysis. Radiation therapy and chemotherapy could not be shown to have significant impact on survival.
CONCLUSION
Complete resection is the most important prognostic factor of retroperitoneal sarcoma. Extensive and aggressive surgery must be considered including resection of adjacent organs. Multiple resection seems to improve survival in recunent cases.

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Germline Mutation of BRCA2 Gene in Korean Breast / Ovarian Cancer Families: Yong Jin Won, Jae Hwan Oh, Ji Hyun Kim, Dong Young Noh, Kuk Jin Choe, Soon Beom Kang, Lee Su Kim, Man Su Ro, Nam Sun Paik, Dae Hyun Yang, Se Min Oh, Soon Nam Lee, Kyung Kook Kim, Jae Gahb Park; J Korean Cancer Assoc. 1998;30(2):242-252.

Abstract PDF: PURPOSE
Recent discovery of BRCA1 and BRCA2 genes has made it possible to perform presymptomatic diagnosis in hereditary breast/ovarian cancer families. We have previously reported germline mutations of the BRCA1 gene in Korean hereditary breast/ovarian cancer families. In that study two out of 13 families were found to have germline mutations in BRCA1 gene. One was a nonsense mutation in codon 1815, and the other was a frameshift mutation due to 2 base-pair deletion in codon 1701 of BRCA1 gene. This study was intended to identify germline mutations of the BRCA2 gene in Korean breast/ovarian cancer families.
MATERIALS AND METHODS
Peripheral blood DNA was obtained from 10 breast cancer patients registered at the Korean Hereditary Tumor Registry with positive family history of breast and/or ovarian cancer. Exons 11 and 27 of the BRCA2 gene(together accounting for 50% of the coding region of the BRCA2 gene) were amplified by polymerase chain reaction(PCR) and screened for mutations by in vitro transcription/translation method. For confirmation of the mutations, automatic sequencing of the PCR products displaying abnormal truncated protein bands was perfomed.
RESULT
We identified an abnormal truncated protein in the exon 11 of the BRCA2 gene from a member of hereditary breast cancer family, SNU-B4. Sequencing analysis revealed a 4 bp deletion in codons 1248-49 of the exon 11, resulting in frameshift that led to premature stop codon and truncation of the protein product.
CONCLUSION
We have identified a germline mutation from a Korean hereditary breast cancer family. So far only one case of the same mutation has been registered in Database of BRCA2 mutation (BIC) by a commercial genetic diagnosis company, Myriad Genetics, Inc. Identification of the germline mutation in BRCA2 gene should aid in the accurate presymptomatic diagnosis of the at-risk members in this family.

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Clinicopathologic Analysis of 40 Mucinous Breast Carcinomas: Woo Jin Choe, Han Sung Kang, Ji Soo Kim, Dong Young Noh, In Ae Park, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe; J Korean Cancer Assoc. 1998;30(1):106-112.

Abstract PDF: PURPOSE
Mucinous carcinoma of breast was known to have a lower lymph node metastasis and better prognosis than other type of breast cancer. This study was performed to clarify the clinicopathologic features and prognosis of mucinous breast carcinoma.
MATERIALS AND METHODS
We reviewed clinicopathologic features of 40 patients diagnosed mucinous breast carcinoma from Jan. 1985 to Dec. 1995 and compared 31 patients of unmixed mucinous breast carcinoma with 1128 patients of infiltrating ductal carcinoma group.
RESULTS
Of total 40 mucinous ca., 31 cases were unmixed type showing no component of invasive ductal component(IDC) and 9 cases were mixed type showing IDC. The average age of the patients was 47 ranging from 31 to 71 years. The most common symptom was palpable breast mass(38 cases, 95%). According to TNM classification, the numbers of unmixed type were following, stage I 14 cases(45%), stage II 15 cases(48%), and stage III 2 cases(7%), and of mixed type, stage I 1 cases(11%), and stage II was 8 cases(89%). Axillary lymph node metastasis was shown to be negative in 26 cases of unmixed mucinous carcinoma(84%), whereas it did in 544 cases of infilterating ductal carcinoma(48%)(p<0.05). Because all patients with unmixed mucinous carcinoma survived except 2 patients who died of cancer unrelated causes, it was impossible to analyze the difference of outcome in unmixed mucinous carcinoma and infilterating ductal carcinoma(5YSR: 81%).
CONCLUSION
Considering unmixed mucinous carcinoma had fewer axillary lymph node metatasis than infiterating ductal carcinoma, it may be concluded that unmixed mucinous carcinoma had better prognosis.

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Clinical Review of Familial and Hereditary Breast Cancer: Young Joon Ahn, Han Sung Kang, Ji Soo Kim, Dong Young Noh, Yeo Kyu Youn, Jae Gahb Park, Seung Keun Oh, Kuk Jin Choe; J Korean Cancer Assoc. 1998;30(1):119-126.

Abstract PDF: PURPOSE
Family history of breast cancer can increase woman's risk of having the disease two to threefold. Patients with familial breast cancer affect the younger at diagnosis and have higher frequency of bilateral disease than those with sporadic cases. We evaluated the characteristics of familial breast cancer(FBC) patients including hereditary breast cancer(HBC) and compared those to sporadic breast cancer(SBC). MATERIALS & METHODS: Of the 885 patients operated on for breast cancer from January 1991 to December 1995 in Seoul National University hospital, 18 patients(2.0%) were classified as familial breast cancer and 5 patients as hereditary breast cancer by definition.
RESULTS
The mean age of the patients was 45.7 years in FBC, 47.0 years in HBC and 46.8 years in SBC. The bilateral disease were more frequent in family history positive group(FBC; 22.2%, HBC; 60%) than SBC(1.5%) (p<0.01). In this series, there were no statistical differences in the age at onset, tumor location, histopathologic types and clinical stages amomg the different groups of the breast cancer, but bilateral cancer were seen more often in the familial history positive group than the other groups.
CONCLUSION
As the frequency of familial and hereditary breast cancer was relatively low compared to that seen in other western countries, it would be necessary for the physician to inquire the family history of pateints with the breast cancer more carefully.

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Germline Mutations of BRCA1 Gene in Korean Breast and/or Ovarian Cancer Families: Yong Jin Won, Jae Hwan Oh, Xiao Hong Huang, Dong Young Noh, Kuk Jin Choe, Soon Beom Kang, Lee Su Kim, Man Su Noh, Nam Sun Paik, Dae Hyun Yang, Se Min Oh, Soon Nam Lee, Jae Gahb Park; J Korean Cancer Assoc. 1997;29(5):713-723.

Abstract PDF: PURPOSE
To understand the involvement of BRCA1 gene in Korean breast and/or ovarian cancer families.
MATERIALS AND METHODS
Germline mutations of BRCA1 gene were analyzed in 13 families which included 3 hereditary site-specific breast cancer families, 6 suspected breast cancer families, and 3 suspected breast-ovarian cancer family, and one Li-Fraumeni family by screening BRCA1 gene using single strand conformation polymorphism (SSCP) analysis on polymerase chain reaction (PCR) amplified genomic DNA and confirmed the results by sequencing.
RESULTS
Including one family with previously reported nonsense mutation of BRCA1 gene, we detected two mutations in unrelated families. One newly identified mutation was frame shift mutation resulting from TG deletion in codon 1701, which results in a truncated BRCA1 protein, at codon 1714.
CONCLUSION
The proportion of families who inherit the mutated BRCA1 gene seems to be small among Korean breast and/or ovarian cancer families.

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A Clinicopathologic Analysis of Medullary Breast Cancer: Myung Chul Chang, Jee Soo Kim, Ik Jin Yun, Dong Young Noh, Yeo Kyu Youn, Seung Keun Oh, Kuk Jin Choe, In Ae Park; J Korean Cancer Assoc. 1997;29(3):422-428.

Abstract PDF: PURPOSE
Medullary carcinoma of breast was known to have a better prognosis than other breast cancer, but the histopathological definition of medullary carcinoma has varied with time. This study was performed to clarify the clinicopathologic features of medullary breast cancer.
MATERIALS AND METHODS
Twenty cases of breast cancer originally were diagnosed as medullary carcinoma at the Department of Surgery, Seoul National University Hospital from Jan. 1985 to Jun. 1995. The whole cases were reviewed and reclassified using the strictly defined histologic criteria applied by Ridolfi et al.
RESULTS
When reclassified, 16 tumors fulfilled the criteria of typical medullary cancer. But the rest 4 tumors were found to be nonmedullary cancer. The patients ranged from 29 to 69 years in age with an average of 49. The main symptom was the painless mass. The diameter of the tumor ranged from 1 to 8 cm with a mean size of 2.7 cm. The axillary lymph node was positive in three cases. The estrogen receptor was positive in 10%, and the progesterone receptor was positive in 20% of the cases. There were no local recurrences or distant metastasis during a mean follow-up period of 5.5 years.. All patients survived until the last follow-up.
CONCLUSION
Medullary breast cancer has good prognosis but strict, uniform histopathological diagnostic criteria are needed.

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Prognostic Fastors in Gastric Leiomyosarcoma: Jin Suk Hu, Han Kwang Yang, Ik Jin Yun, Jong Kwon Park, Gyeong Hoon Kang, Ja June Jang, Seung Keun Oh, Jin Pok Kim, Ja June Jang, Dong Young Noh, Yeo Kyu Yong, Seung Keun Oh, Kuhn Uk Lee, Kuk Jin Choe; J Korean Cancer Assoc. 1996;28(6):1055-1061.

Abstract PDF: Objectives
The aim of our study was to analyze prognostic factors in gastric leiomyosarcoma. Method: We retrospectively reviewed the medical records of 33 patients with pathologcally proven leiomyosarcoma diagnosed from 198l through August 1995. All 33 gastric leiomyosarcoma were histologically confirmed by the pathologist. The factors analyzed are patient age, sex, tumor location, surgical procedure, tumor size, histologic grade, p53 and nm23. Expression of p53(positive vs. negative) and type of nm23 expression(diffuse vs. granular) were measured by immunohistochemical staining in 25 surgically resected specimens. The survival curves obtained by Kaplan-Meyer methods were compared using Log-rank test. Result: The 33 patients represents 0.39% of all patients with 8370 gastric cancer patients presenting during the same period. There were 23 males and 10 females. The mean age at the time of diagnosis was 57 years. Forty percent(13/33) of the tumors were located in the body, 30% (10/33) in fundus and 21%(7/33) in cardia of the stomach. Only three tumors(9%) were located in the antrum. Twenty seven of these tumors were treated by radical gastrectomy and 6 were treated by wedge resection. Histologically, 34.9% were low grade and 65.1% were high grade. Metastatic involvement was noted in four of patients at the time of diagnosis. p53 overexpression was positive in 28%. nm23 expression was positive in all cases; 72% were diffuse type and 28% were granular type. The 5-year survival rates of all cases were 79% and the 5-year disease free survival rates were 52%. Among the factors analyzed, the tumor size was the only significant prognostic factor. 5 year survival rete was 100% for tumors less than 10cm(n=16) and 55% for tumors larger than 10cm(n=l7). Tumor size and tumor grade were significant prognostic factor in disease free surviva. Conclusion: Our data suggest that leiomyosarcoma representing very small portion of gastric cancer were more commoly located in the upper part of stomach. Variables such as age, sex, tumor lacation, type of surgery, p53 overexpression and type of nm23 expression did not have prognostic significance. Tumor size was the only significant prognostic factor in overall survival(p<0.05). Tumor size and tumore grade were significant factors in disease free survival(p<0.05). The authors believe that these data will provide selection criteria for future clinical studies.

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A Clinical Study of 14 Cases of Male Breast Cancer: Kuy Hee Her, Dong Young Noh, Ik Jin Yun, Woo Chul Noh, Han Kwang Yang, Kuk Jin Choe; J Korean Cancer Assoc. 1995;27(6):940-948.

Abstract PDF: Male breast cancer is uncommon disease accounting for approximately 1% of all breast cancers. Its rarity may prevent many physicians from seeing its natural history, cause, pathologic features, and pragnosis. Compared with female breast cancer, breast cancer in men accurs in older age groups, manifests in a more advanced state, and produces higher incidence of central location and ulceration. A clinical study was performed to the 14 cases of male breast cancer patients at the department of surgery, Seoul National university in a 14-year span, from Jan. 1981 to Dec. 1994. The results were as fallowings; 1) Prevalent age group was 8th decade(35.7%) 2) Their most common symptom was palpable mass(85.7%) 3) Five patients(35.7%) visited hospital over 1 year had passed 4) There were nine tumors(64.3%) situated in the left breast and eleven tumors(78.6%) were circumareola located 5) According to the TNM staging system, 6 cases(42.9%) were advanced(over stage III) stage breast cancer 6) Curative resections were performed in ten patients(71.4%) the procedures were 2 cases of Radical Mastectomy, 4 cases of Modified Radical Mastectomy, 4 cases of Simple Mastectomy and Axillary node dissection 7) Postoperative adjuvant therapies including multimodality approach were performed in 7 cases of the patients 8) Nine patients were expired, 6 were died of recurrences or metastases of the breast cancer and 3 were the other causes, the median survival period was 44 months. We observed that male breast cancer were detected older and far advanced. So early detection and treatment are important to promote the survival of the male breast cancer patients

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Germline Mutation of BRCA1 Gene in Korean Breast and Overian Cancer Patients: Jae Hwan Oh, Dong Young Noh, Kuk Jin Choe, Soon Beom Kang, Lee Su Kim, Man Su Ro, Nam Sun Paik, Dae Hyun Yang, Se Min Oh, Soon Nam Lee, Jae Gahb Park; J Korean Cancer Assoc. 1995;27(6):1061-1070.

Abstract PDF: We analyzed germline mutations of the BRCAl gene in 29 Korean breast cancer patients, which included ¨c 10 breast cancer patients with family history of breast or ovarian cancer, ¨e 7 early onset breast cancer patients without family history of breast or ovarian cancer(1ess than 40 years old at diagnosis) and ¨e 12 breast cancer patients without family history of breast or ovarian cancer(more than 40 years old at diagnosis), and 1 hereditary ovarian cancer patient. One nonsense mutation at codon 1815 encoding a truncated protein was detected in a breast cancer patient with family history of ovarian cancer. One missense mutation at codon 1630 was detected in a group of breast cancer patients without family history(more than 40 years old at diagnosis), but still not determined whether it was polymorphism or not. Three polymorphisms were detected, which included 2 cases of silent mutation and a case of missense mutation. In early onset breast cancer group and a familial ovarian cancer patient, there was no detected mutation. We confirmed a germline BRCAl gene mutation in one Korean patient of hereditary breast-ovarian cancer family.

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Discrepancies between the Biochemical and Immunohistochemical Assays of the Progestrone Receptor : Correlations with Classical Prognostic Factors in Breast Carcinoma: Dae Yeon Kim, Se Hwan Han, Dong Young Noh, In Ae Park, June Key Chung, Kuk Jin Choe; J Korean Cancer Assoc. 1995;27(1):69-77.

Abstract PDF: Breast cancer specimens from 77 patients were assayed for the presence of progesterone receptors (PR) utilizing the biochemical assay (Dextran Coated Charcoal) and immunohistochemical assay (ICA). The PR status of these patients were evaluated in respect to age and size of the tumor, axillary lymph-node metastasis, and cell differentiation according to the each method. The number of PR positive tumor was 23 cases (29.9%) in DCC and 42 cases (54.5%) in PR-ICA. The concordance of both assays is 0.304. There was no correlation between PR status and the age of patients in both assays. There was increase of PR expression in smaller tumor, but that was significanfin only ICA (P<0.05). The relationship between axillary lymph- node metastasis and PR expression was not proven by ICA but there was significant increase of PR positive ratio in lesser axillary lymph-node metastasis with DCC method (P<0.05). The relationship between TNM stage and PR expression was not proven by ICA method but there was significant increase of PR positive ratio in early TNM stage with DCC method (P<0.05). The relationship between histologic grade and PR expression was not observed. In this study, the results of ICA showed higher expression rate than DCC method. The ICA was correlated with the size of tumor, while the DCC assay was correlated with the axillary lymph-node metastasis and stage.

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Expression of nm23-H1 in Breast Cacner and Its Clinical Significance: Se Hwan Han, Dong Young Noh, Jin Suk Hu, Kuk Jin Choe, Sang Yong Song, Je Geun Chi; J Korean Cancer Assoc. 1994;26(6):936-943.

Abstract PDF: The nm23-Hl gene, identified from murine melanoma cell line, is located in the chromosome 17q22. Its meaning as an anti-metastatic marker was potentiated by the fact that the transfection of nm23-Hl gene into a murine melanoma cell line with high metastatic potential resulted in a change to decreased metastatic capability. This study was designed to determine the frequency of nm23 protein expression in human breast carcinoma and to compare its result with other established prognostic parameters. We studied 8S breast carcinoma samples for the expression of anti-nm23/nucleoside diphosphate kinase A using immunohistochemical analysis. All the patients were female and 7 cases(8%) were not stained immunohistochemically. Among the positively stained group, 43 cases(48.9%) were weakly positive and 38 cases(43.2%) were stained strongly. Expression of nm23 decreased significantly as the tumor size increased and in axillary lymph node metastasis group. There was decreasing tendency of nm23 expression as the nuclear grade increased. Estrogen receptor status or menopausal status did not correlate with nm23 expression. The disease free survival rate was superior in the group with strongly positive expression of nm23. In conclusion, the results suggest that expression of nm23 protein may have a role in the suppression of lymph node metastasis in breast carcinoma.

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Correlation of c-erbB-2 protooncogene amplification with estrogen receptor status in human breast cancer: Hang Jun Cho, Dong Young Noh, Kuk Jin Choe, Ju Bae Park; J Korean Cancer Assoc. 1992;24(6):821-828.

Abstract PDF: No abstract available.

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Malignant cystosarcoma phyllodes: Dong Young Noh, Soo Jin Kim, Kuk Jin Choe, Jin Pok Kim, Woo Ho Kim; J Korean Cancer Assoc. 1992;24(5):730-736.

Abstract PDF: No abstract available.

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Recurrent carcinoma of the thyroid: Byung In Moon, Dong Young Noh, Seung Keun Oh; J Korean Cancer Assoc. 1992;24(3):422-427.

Abstract PDF: No abstract available.

2,017 View
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DNA ploidy, S-phase activity and c-erbB-2 oncogene protein expression in breast cancer and its relationship to prognosis: Dong Young Noh, Kuk Jin Choe, Jin Pok Kim, In Ae Park, Seong Hoe Park, Keun Young Yoo; J Korean Cancer Assoc. 1992;24(1):73-81.

Abstract PDF: No abstract available.

2,244 View
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Proportionality assuption test of Cox's proportional hazards model in survival analysis: Moo Song Lee, Keun Young Yoo, Dong Young Noh, Kuk Jin Choe; J Korean Cancer Assoc. 1991;23(4):852-859.

Abstract PDF: No abstract available.

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Comparison of biochemical assay and immunohistochemical assay of estrogen receptor in breast carcinomas: Dong Young Noh, Se Hwan Han, Kuk Jin Choe, Jin Pok Kim, Myung Chul Lee, Seong Hae Park; J Korean Cancer Assoc. 1991;23(4):749-754.

Abstract PDF: No abstract available.

2,505 View
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A clinical study of breast cancer: Dong Young Noh, Deuk Ho Cha, Jae Won Jo, Young Jin Song, Oh Jung Kwon, In Kyu Hong, Kuk Jin Choe, Jin Pok Kim; J Korean Cancer Assoc. 1991;23(2):410-417.

Abstract: No abstract available.

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Effect of growth factors and differentiation inducer DMSO on the anaplastic thyroid carcinoma cell line, SNU-80: Seung Keun Oh, Dong Young Noh, Jae Gahb Park; J Korean Cancer Assoc. 1991;23(2):237-246.

Abstract PDF: No abstract available.

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Establishment of SNU cell lines: november 1989-august 1990: Jae Gahb Park, You Me Jeon, Kyu Ju Park, Han Kwang Yang, Dong Young Noh, Sun Whe Kim, Seung Keun Oh, Kuhn Uk Lee, Yong Hyun Park, Kuk Jin Choe, Jin Pok Kim, Soo Tae Kim; J Korean Cancer Assoc. 1991;23(2):169-187.

Abstract PDF: No abstract available.

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Correlation of c-erbB-2 protein overexpression in human breast carcinoma with nodal status, tumor size, stage, age and survival: Byung Sik Kim, Dong Young Noh, Kak Jin Choe, Kuhn Kuk Lee, Seong Hoe Park, Yong Il Kim, Joo Bae Park; J Korean Cancer Assoc. 1991;23(1):20-28.

Abstract PDF: No abstract available.

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Synergistic Effect of Cisplatin and 5 - Fluorouracil Against Gastric and Colon Cancer Cell Line: Yoon Sik Kang, Dong Young Noh, Jae Gahb Park, Kuk Jin Choe; J Korean Cancer Assoc. 1990;22(3):490-505.

Abstract PDF: The purpose of this study was to elucidate the synergistic effect of cisplatin and 5-fluorouracil against human gastric and colon cancer cell lines. Since it is virtually impossible to document supraadditive tumor cell kill in vivo, this in vitro experiment implicates the interaction of these agents at a cellular level. We used an in vitro tetrazolium-based colorimetric assay for cytotoxicity (MTT assay) and an isobologram analysis to test combination effects of the two drugs against gastric and colon cancer cell lines, SNU-1, SNU-5, SNU-16, SNU-CI, SNU-C2A, SNU-C4, SNU-C5 those were established at cancer research institue of Seoul National University and NC1-N87 from NCI, VSA. As a resuh, those drug combination applied to this experiment didnt show a synergistic effect except in SNU-1 cell line demonstrated partly synergistic effect. Then we conclude that there are lack of in vitro synergistic effect between cisplatin and 5- fluorouracil against gastric and colon cancer cell lines, and that methodology we adopted can be one index ta check the combinatian effect of anticancer drugs.

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Establishment of SNU Cell Lines in Growth Factor and Growth hormone Supplemented Medium: Jae Gahb Park, Nam Sook Kwon, Dong Young Noh, In Gyu Hong, Seung Keun Oh, Kuhn Uk Lee, Yong Hyun Park, Sung Kuk Hong, Kuk Jin Choe, Jin Pok Kim, Soo Tae Kim, Dae Seog Heo, Yung Jue Bang, Seon Yang Pa; J Korean Cancer Assoc. 1990;22(1):1-14.

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Early Gastric Cancer - 137 cases -: Jin Pok Kim, Jae Gahb Park, Dong Young Noh, In Hyuk Oh, Chung Yong Kim, Kyoo Wan Choi, In Sung, Man Chung Han, Yong Il Kim; J Korean Cancer Assoc. 1983;15(1):42-50.

Abstract PDF: During a thirteen year period from May 1969 to December 1982, 137 cases of early gastric cancer were treated and we could follow 130 cases among them. The incidence of EGC among resected stomach was(9.7%). The male; female ratio was l.8:1 and their average age was 47.2 years. By UGI, double contrast x-ray study, 52.6% of them were diagnosed or suspected as EGC and by gastroscopy 62.6% of them were diagnosed or suspected as EGC. Fifty five cases(42.6%) of them were confined to the mucosa and 74 cases(57.4%) of them were confined to the submucosa. Two cases(3.6%) of mucosal cancer and 20 cases(27%) of submucosal cancer showed lymph node invasion. The most frequent macrotype of EGC was IIc(40%) and microtype was signet ring cell type(39%). The five year survival rate of mucosal cancer was 100% and submucosal cancer was 91% so overall 95%. Since the clinical features do not provide guidelines to diagnosis and there is no ecreening test yet, the diagnosis depends on double contrast barium studies, endoscopy with biopsy and their interpretation. And early detection of the stomach cancer is the most important to improve its pragnosis.

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