- Pediatric cancer
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The Broad Variability in Dental Age Observed among Childhood Survivors Is Cancer Specific
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Patrycja Proc, Joanna Szczepańska, Małgorzata Zubowska, Beata Zalewska-Szewczyk, Wojciech Młynarski
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Cancer Res Treat. 2021;53(1):252-260. Published online August 24, 2020
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DOI: https://doi.org/10.4143/crt.2020.275
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 Abstract
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- Purpose
The study aimed to assess the differences in dental maturation between childhood cancer survivors and healthy children.
Materials and Methods
Fifty-nine cancer patients including 16 (27.1%) girls and 43 (72.8%) boys, aged between 4 and 16 years, underwent dental and radiographic examinations. The mean duration of anticancer therapy was 16.8 months (range, 1 to 47 months), and 4.6 years (range, 8 to 123 months) had passed since the termination of disease. The control group consisted of 177 panoramic radiographs of age- and sex-matched healthy individuals. Dental age (DA) was estimated with Demirjian’s scale and delta age, i.e., DA–chronological age (CA), was used to compare groups.
Results
The DA of cancer survivors was accelerated by almost 1 year compared to their CA (9.9±3.1 vs. 8.9±2.8, p=0.040). The greatest difference was observed among patients with brain tumor: delta (DA–CA) was 2.2±1.1 years. Among all cancer patients, only children with familial adenomatous polyposis (FAP)-associated hepatoblastoma (HP) demonstrated delayed DA, with regard to both other cancer survivors (p=0.011) and healthy patients (p=0.037). All four patients with HP suffered from FAP, and three of them had documented adenomatous polyposis coli (APC) genes mutation. The DA of cancer patients having teeth with short roots was significantly greater than that of the cancer survivors without this anomaly (12.8±3.2 vs. 9.0±2.4, p < 0.001).
Conclusion
DA in children may be altered by cancer disease.
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Citations
Citations to this article as recorded by  - Dental management of long-term childhood cancer survivors: a systematic review
K. Seremidi, S. Gizani, G. Dahllöf, M. Barr-Agholme, D. Kloukos, G. Tsilingaridis
European Archives of Paediatric Dentistry.2024; 25(5): 611. CrossRef - Dental age estimation in children that have undergone antineoplastic treatment
A. Mitsea, K. Seremidi, A. Tsiligianni, S. Gizani
European Archives of Paediatric Dentistry.2022; 23(2): 243. CrossRef - Comparative Study of Malocclusions between Cancer Patients and Healthy Peers
Patrycja Proc, Joanna Szczepanska, Anna Herud, Malgorzata Zubowska, Wojciech Fendler, Monika Lukomska-Szymanska, Wojciech Mlynarski
International Journal of Environmental Research and Public Health.2022; 19(7): 4045. CrossRef
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