-
Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer
-
Joel Rivera-Concepcion, Dipesh Uprety, Alex A. Adjei
-
Cancer Res Treat. 2022;54(2):315-329. Published online February 18, 2022
-
DOI: https://doi.org/10.4143/crt.2022.078
-
-
Abstract
PDF PubReader ePub
- Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing amounts of identifiable oncogene drivers have led to the development of molecularly targeted drugs. Undoubtedly, the future of thoracic oncology is shifting toward increased molecular testing and the use of targeted therapies. For the most part, these novel drugs have proven to be safe and effective. As with all great innovations, targeted therapies pose unique challenges. Drug toxicities, resistance, access, and costs are some of the expected obstacles that will need to be addressed. This review highlights some of the major challenges in the use of targeted therapies in NSCLC and provides guidance for the future strategies.
-
Citations
Citations to this article as recorded by 
- NSCLC: Current Evidence on Its Pathogenesis, Integrated Treatment, and Future Perspectives
Kareem Tahayneh, Mayar Idkedek, Firas Abu Akar Journal of Clinical Medicine.2025; 14(3): 1025. CrossRef - Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments?
Meekha George, Rabah Boukherroub, Amitav Sanyal, Sabine Szunerits Materials Today Bio.2025; 31: 101616. CrossRef - Suppression of the LKB1-AMPK-SLC7A11-GSH signaling pathway sensitizes NSCLC to albumin-bound paclitaxel via oxidative stress
Dade Rong, Liangliang Gao, Yiguan Chen, Xiang-Zheng Gao, Mingzhu Tang, Haimei Tang, Yuan Gao, Guang Lu, Zhi-Qiang Ling, Han-Ming Shen Redox Biology.2025; 81: 103567. CrossRef - Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment
Thiagarajan Madheswaran, Dinesh Kumar Chellappan, Fiona Sze Nee Lye, Kamal Dua Expert Opinion on Drug Delivery.2025; 22(5): 615. CrossRef - Addressing Challenges in Targeted Therapy for Metastatic Colorectal Cancer
Maria El Hage, Zhaoran Su, Michael Linnebacher Cancers.2025; 17(7): 1098. CrossRef - Nanoformulations: Reforming treatment for non-small cell lung cancer metastasis
Shristy Jha, Mangala Hegde, Ruchira Banerjee, Mohammed S. Alqahtani, Mohamed Abbas, Habib M. Fardoun, Jyothsna Unnikrishnan, Gautam Sethi, Ajaikumar B. Kunnumakkara Biochemical Pharmacology.2025; 238: 116928. CrossRef - Optimized PEGylated cubosomes: a novel approach for specific delivery of dacomitinib to non-small cell lung cancer cells
Mohamed Nasr, Rania Mokhtar, Rania S. Abdel-rashid Materials Advances.2025;[Epub] CrossRef - Navigating advanced lung cancer care, patient–physician alliance, cancer stigma, and psychosocial support in Asia-Pacific: perspectives from patients, caregivers, and physicians
Chee Khoon Lee, Xue Yang, Yasushi Goto, Kang Yun Lee, Hyung Seok Yim, Mark Brooke, Hisakazu Aoshima, Emiko Ando, Yiting Liu, Jane Tsai, Grace Kah Mun Low, Naomi Kishiwada, Simone Marie Cheng, Divashini Rajendran, Regina Gowindah, Soe Pwint Phoo Mon, Min H Future Oncology.2025; : 1. CrossRef - Development of a multi-neoepitope vaccine targeting non-small cell lung cancer through reverse vaccinology and bioinformatics approaches
Elahe Asadollahi, Alireza Zomorodipour, Zahra-Soheila Soheili, Babak Jahangiri, Majid Sadeghizadeh Frontiers in Immunology.2025;[Epub] CrossRef - A Comprehensive Review of Long Non-Coding RNAs in the Cancer–Immunity Cycle: Mechanisms and Therapeutic Implications
Mario Perez-Medina, Jesus J. Benito-Lopez, Dolores Aguilar-Cazares, Jose S. Lopez-Gonzalez International Journal of Molecular Sciences.2025; 26(10): 4821. CrossRef - Driving Best Practices Throughout the Treatment Journey for Patients with NSCLC with Actionable Alterations: A Podcast Discussion
Christine M. Bestvina, Chul Kim, Nathalie Daaboul Advances in Therapy.2025;[Epub] CrossRef - A local perspective on internal, external, and reflexive biomarker testing processes for lung cancer in an academic medical center
Andrea M. Russell, Allison P. Pack, Stacy C. Bailey, Christine B. Weldon, Marie S. Dreyer, Sheetal M. Kircher, Michael S. Wolf Cancer.2024; 130(12): 2085. CrossRef - Advances in BRAF-targeted therapies for non-small cell lung cancer: the promise of encorafenib and binimetinib
Areeba Fareed, Nabiha Amir, Humna Ajaz, Afra Sohail, Rayyan Vaid, Solay Farhat International Journal of Surgery.2024; 110(4): 1891. CrossRef - Drug Repurposing: Exploring Potential Anti-Cancer Strategies by Targeting Cancer Signalling Pathways
Natalia Haddad, Sara Magura Gamaethige, Nadine Wehida, Ahmed Elbediwy Biology.2024; 13(6): 386. CrossRef - Exploring the Potential of Antibody-Drug Conjugates in Targeting Non-small Cell Lung Cancer Biomarkers
Avinash Khadela, Kaivalya Megha, Vraj B Shah, Shruti Soni, Aayushi C Shah, Hetvi Mistry, Shelly Bhatt, Manthan Merja Clinical Medicine Insights: Oncology.2024;[Epub] CrossRef - Decreased aggressive care at the end of life among advanced cancer patients in the Republic of Korea: a nationwide study from 2012 to 2018
Sara Kwon, Kyuwoong Kim, Bohyun Park, So-Jung Park, Hyun Jung Jho, Jin Young Choi BMC Palliative Care.2024;[Epub] CrossRef - Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy
Jian Wang, Ming Zhang, Xin You, Yang Xu, Congcong Zhang, Ying Li, Chunhui Yang, Qi Wang Frontiers in Pharmacology.2024;[Epub] CrossRef - Next-generation sequencing impact on cancer care: applications, challenges, and future directions
Mariano Zalis, Gilson Gabriel Viana Veloso, Pedro Nazareth Aguiar Jr., Nathalia Gimenes, Marina Xavier Reis, Silvio Matsas, Carlos Gil Ferreira Frontiers in Genetics.2024;[Epub] CrossRef - Expression and Functional Analysis of Immuno-Micro-RNAs mir-146a and mir-326 in Colorectal Cancer
Ovidiu Farc, Liviuta Budisan, Florin Zaharie, Roman Țăulean, Dan Vălean, Elena Talvan, Ioana Berindan Neagoe, Oana Zănoagă, Cornelia Braicu, Victor Cristea Current Issues in Molecular Biology.2024; 46(7): 7065. CrossRef - Advances in Non-Small Cell Lung Cancer: Current Insights and Future Directions
Pankaj Garg, Sulabh Singhal, Prakash Kulkarni, David Horne, Jyoti Malhotra, Ravi Salgia, Sharad S. Singhal Journal of Clinical Medicine.2024; 13(14): 4189. CrossRef - Proceedings from the First Onco Summit: LATAM Chapter, 19–20 May 2023, Rio de Janeiro, Brazil
Vania Hungria, Anna Sureda, Garcia Rosario Campelo, Marco Aurélio Salvino, Karthik Ramasamy Cancers.2024; 16(17): 3063. CrossRef - Non-small-cell lung cancer
Lizza E. L. Hendriks, Jordi Remon, Corinne Faivre-Finn, Marina C. Garassino, John V. Heymach, Keith M. Kerr, Daniel S. W. Tan, Giulia Veronesi, Martin Reck Nature Reviews Disease Primers.2024;[Epub] CrossRef - A phase Ib study of the combination of naporafenib with rineterkib or trametinib in patients with advanced and metastatic KRAS- or BRAF-mutant non-small cell lung cancer
David Planchard, Jürgen Wolf, Benjamin Solomon, Martin Sebastian, Martin Wermke, Rebecca S. Heist, Jong-Mu Sun, Tae Min Kim, Noemi Reguart, Miguel F. Sanmamed, Enriqueta Felip, Pilar Garrido, Armando Santoro, Douglas Bootle, Xuân-Mai Couillebault, Anil Ga Lung Cancer.2024; 197: 107964. CrossRef - CIGB-300 internalizes and impairs viability of NSCLC cells lacking actionable targets by inhibiting casein kinase-2 signaling
Ying Yi, Lingfeng Dai, Yaqin Lan, Changyuan Tan, Dania M. Vázquez-Blomquist, Guirong Zeng, Dejian Jiang, Ke Yang, Silvio E. Perea, Yasser Perera Scientific Reports.2024;[Epub] CrossRef - Hemin Promotes Higher Effectiveness of Aminolevulinic-Photodynamic Therapy (ALA-PDT) in A549 Lung Cancer Cell Line by Interrupting ABCG2 Expression
Anantya Pustimbara, Rahma Wirdatul Umami, Nurul Muhammad Prakoso, Anna Rozaliyani, Jamal Zaini, Astari Dwiranti, Shun-ichiro Ogura, Anom Bowolaksono Medical Sciences.2024; 12(4): 66. CrossRef - Expansion of an Academic Molecular Tumor Board to Enhance Access to Biomarker-Driven Trials and Therapies in the Rural Southeastern United States
Anivarya Kumar, Jennifer R. Owen, Nicholette T. Sloat, Elizabeth Maynard, Vanessa M. Hill, Christopher B. Hubbard, Matthew S. McKinney, Linda M. Sutton, Shannon J. McCall, Michael B. Datto, Ashley N. Moyer, Bennett A. Caughey, John H. Strickler, Ryne C. R Current Oncology.2024; 31(11): 7244. CrossRef - Prognostic score and sex-specific nomograms to predict survival in resectable lung cancer: a French nationwide study from the Epithor cohort database
Marco Alifano, Elisa Daffré, Laurent Brouchet, Pierre Emmanuel Falcoz, Françoise Le Pimpec Barthes, Pierre Benoit Pages, Pascal Alexandre Thomas, Marcel Dahan, Raphael Porcher The Lancet Regional Health - Europe.2023; 26: 100566. CrossRef - Proteolysis targeting chimeras in non-small cell lung cancer
Garo Hagopian, Christopher Grant, Misako Nagasaka Cancer Treatment Reviews.2023; 117: 102561. CrossRef - Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration
Dong-Dong Wu, Yasmine Ahmed Salah, Ebenezeri Erasto Ngowi, Yan-Xia Zhang, Saadullah Khattak, Nazeer Hussain Khan, Yan Wang, Tao Li, Zi-Hua Guo, Yan-Mei Wang, Xin-Ying Ji iScience.2023; 26(8): 107321. CrossRef - Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer
Giulia Maria Stella, Sara Lettieri, Davide Piloni, Ilaria Ferrarotti, Fabio Perrotta, Angelo Guido Corsico, Chandra Bortolotto Pharmaceuticals.2023; 16(7): 1042. CrossRef - Recent advances in non-small cell lung cancer targeted therapy; an update review
Mahmood Araghi, Reza Mannani, Ali Heidarnejad maleki, Adel Hamidi, Samaneh Rostami, Salar Hozhabri Safa, Fatemeh Faramarzi, Sahar Khorasani, Mina Alimohammadi, Safa Tahmasebi, Reza Akhavan-Sigari Cancer Cell International.2023;[Epub] CrossRef - AXL transcriptionally up-regulates TMEM14A expression to mediate cell proliferation in non-small-cell lung cancer cells
Te-Hsuan Jang, Sheng-Chieh Lin, Ya-Yu Yang, Shu-Hui Wu, Tsu-Hsiang Kuo, Shuang-En Chuang Biochemical and Biophysical Research Communications.2023; 682: 365. CrossRef - Applications of nanofibers drug delivery system in cancer therapy
Nafiu Aminu, Salim Ilyasu, Mohammed Al-Kassim Hassan, Fatima Shuaibu Kurfi, Abubakar Ibrahim Jatau, Siok-Yee Chan, Deghinmotei Alfred-Ugbenbo Journal of Drug Delivery Science and Technology.2023; 90: 105128. CrossRef - Exploring the Anticancer Potential of Origanum majorana Essential Oil Monoterpenes Alone and in Combination against Non-Small Cell Lung Cancer
Kholoud Arafat, Aya Mudhafar Al-Azawi, Shahrazad Sulaiman, Samir Attoub Nutrients.2023; 15(23): 5010. CrossRef - Novel Biomarkers in Lung Cancer and Chronic Lung Diseases: From the Systematic Perspective of Yin–Yang Balance
Mi-Kyung Jeong, Jaemoo Chun, In-Jae Oh Journal of Clinical Medicine.2022; 11(15): 4275. CrossRef - Application of Perinatal Derivatives on Oncological Preclinical Models: A Review of Animal Studies
Ricardo Teixo, Ana Salomé Pires, Eurico Pereira, Beatriz Serambeque, Inês Alexandra Marques, Mafalda Laranjo, Slavko Mojsilović, Roberto Gramignoli, Peter Ponsaerts, Andreina Schoeberlein, Maria Filomena Botelho International Journal of Molecular Sciences.2022; 23(15): 8570. CrossRef - Survival benefit of thermal ablation therapy for patients with stage II-III non-small cell lung cancer: A propensity-matched analysis
Wei-Yu Yang, Yu He, Qikang Hu, Muyun Peng, Zhe Zhang, Shouzhi Xie, Fenglei Yu Frontiers in Oncology.2022;[Epub] CrossRef - Molecular targeted therapy for anticancer treatment
Hye-Young Min, Ho-Young Lee Experimental & Molecular Medicine.2022; 54(10): 1670. CrossRef - Transcriptomic FHITlow/pHER2high signature as a predictive factor of outcome and immunotherapy response in non-small cell lung cancer
Audrey Brisebarre, Julien Ancel, Théophile Ponchel, Emma Loeffler, Adeline Germain, Véronique Dalstein, Valérian Dormoy, Anne Durlach, Gonzague Delepine, Gaëtan Deslée, Myriam Polette, Béatrice Nawrocki-Raby Frontiers in Immunology.2022;[Epub] CrossRef - CIGB-300 Anticancer Peptide Differentially Interacts with CK2 Subunits and Regulates Specific Signaling Mediators in a Highly Sensitive Large Cell Lung Carcinoma Cell Model
George V. Pérez, Mauro Rosales, Ailyn C. Ramón, Arielis Rodríguez-Ulloa, Vladimir Besada, Luis J. González, Daylen Aguilar, Dania Vázquez-Blomquist, Viviana Falcón, Evelin Caballero, Paulo C. Carvalho, Rodrigo Soares Caldeira, Ke Yang, Yasser Perera, Silv Biomedicines.2022; 11(1): 43. CrossRef
-
14,583
View
-
341
Download
-
42
Web of Science
-
40
Crossref
|