1Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea. jinwoo@cmc.cuk.ac.kr 2Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
ABSTRACT
PURPOSE: The relationship between altered HLA expressions and ovarian carcinogenesis is not fully elucidated.
MATERIALS AND METHODS: Histological evaluation comprised 20 serous adenocarcinoma, 5 borderline serous malignancy, 10 mucinous adenocarcinoma, 15 borderline mucinous malignancy.
We used monoclonal antibodys to HLA class I beta2-microglobulin, class I B/C and class II heavy chain.
RESULTS: There was no statistical difference in HLA expressions between borderline serous malignancy and normal ovarian tissue. In serous adenocarcinoma, beta2-microglobulin, B/C and class II heavy chain expressions were down-regulated. In metastatic cancer, B/C and class II ex pressions were also down-regulated. But the HLA expression of tumor or normal stromal tissue in primary tumor, were not down-regulated compared with the tissues in metastasis. In borderline mucinous malignancy, class II expressions were down-regulated. In mucinous adenocarcinoma, beta2-microglobulin, B/C and class II expressions were down-regulated. In metastatic ovarian cancer, B/C and class II expressions were down-regulated.
But, in borderline malignancy, the result failed to reach statistical significance except class II of borderline mucinous malignancy.
CONCLUSION: Loss of HLA class I and II molecules in invasive ovarian cancers raises the possibility that this could be a mechanism for tumor cells to have invasiveness.
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