Small round cell tumors in surgical pathology are difficult to be differentiated each other only by routine H & E stain. In this study we applied six antibodies (keratin, vimentin, neuron-specific enolase, S-100 protein, myoglobin and leukocyte common antigen) as a panel marker to 18 cases of primitive neuroectodermal tumor including neuroblastoma, Ewirig's sarcoma, rhabdomyosarcoma, lymphoma, and small cell carcinoma. The results were summerized as follows: I) Primitive neuroectodermal tumor (PNET) and neuroblastoma showed positive reaction for S -100 protein and neuron-specific enolase (NSE). 2) Ewing's sarcomas showed vimentin positivity with occasional positive reaction for NSE and S -100 protein, but it was always negative for myoglobin. 3) Myoglobin was a specific marker for rhabdomyosarcoma, and vimentin might be positive. In myoglobin negative case, immunostaining for desmin was recommended. 4l Leukocyte common antigen positivity always indicated lymphoma. Occasionally vimentin and NSE were positive. 5) In the cases of carcinoma, keratin was positive and occasionally NSE and/or vimentin were positive.
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