This study was performed to evaluate effects of chemotherapeutic agents and polysaccharide-K combination therapy on natural killer cell activity in 29 patients with inoperable stomach cancer. Of total 29 patienta 9 patients received chemotherapy and krestin and 12 patients received chemotherapy and copolang. In 8 control patiente, only chemotherapy was given. All groups showed the decreasing tendency in NK cell activity after 4 weeks' treatment, but in contrast to control group, krestin and copolang group revealed the inclination to restore NK cell activity after H weeks' treatment. There was significant decrease in peripheral lymphocytes count after 8 weeks treatment. No difference in clinical outcome was found during follow up periods among the groups. We expect that the long-term administration of polysaccharide-K would give beneficial effects on inoperable patients with stomach cancer through the mechanism involving augmentation of NK cell activity.
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